{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:54:51Z","timestamp":1792691691358,"version":"4.5.0"},"reference-count":29,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"unspecified","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015739","name":"Bayer Vital","doi-asserted-by":"publisher","award":["na"],"award-info":[{"award-number":["na"]}],"id":[{"id":"10.13039\/100015739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2024,8,9]]},"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Oral anticoagulation (OAC) is key in stroke prevention in patients with atrial fibrillation (AF) but there is uncertainty regarding the optimal timing of OAC (re)initiation after stroke, as recent large randomised controlled trials have methodological weaknesses and excluded stroke patients on therapeutic anticoagulation at stroke onset as well as patients started on a vitamin K antagonist after stroke. The \u20181\u20133\u20136\u201312 days rule\u2019, based on expert consensus and referring to stroke severity, was used in clinical practice to initiate OAC after acute ischaemic stroke or transient ischaemic attack (TIA) since publication in 2013.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively assessed whether compliance to the \u20181\u20133\u20136\u201312 days rule\u2019 was associated with the composite endpoint (recurrent stroke, systemic embolism, myocardial infarction, major bleeding or all-cause death).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 708 registry patients with known AF before stroke and hospitalisation within 72 hours after stroke, 432 were anticoagulated at stroke onset. OAC was started according to the \u20181\u20133\u20136\u201312 days rule\u2019 in 255 (39.2%) patients. Non-adherence to the \u20181\u20133\u20136\u201312 days rule\u2019 was not associated with the composite endpoint within 3 months in 661 patients who (re-)started on OAC (log-rank test: p=0.74).<\/jats:p>\n                  <jats:p>Results were similar for 521 patients (re)started on a non-vitamin K-dependent OAC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>(Re)starting OAC after stroke followed the \u20181\u20133\u20136\u201312 days rule\u2019 in about 40% of all patients with AF, and more often in those anticoagulated at stroke onset. Adherence to the \u20181\u20133\u20136\u201312 days rule\u2019 did not reduce the composite clinical endpoint, if OAC was restarted within 3 months of stroke\/TIA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>\n                     <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT02306824\">NCT02306824<\/jats:ext-link>.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2024-002688","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T02:45:17Z","timestamp":1726713917000},"page":"e002688","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Timing of oral anticoagulation in atrial fibrillation patients after acute ischaemic stroke and outcome after 3 months: results of the multicentre Berlin Atrial Fibrillation Registry"],"prefix":"10.1136","volume":"11","clinical-trial-number":[{"clinical-trial-number":"nct02306824","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct02961348","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct03021928","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct02306824","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8153-3025","authenticated-orcid":false,"given":"Manuel C","family":"Olma","sequence":"first","affiliation":[{"name":"Center for Stroke Research Berlin, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serdar","family":"T\u00fct\u00fcnc\u00fc","sequence":"additional","affiliation":[{"name":"Charit\u00e9 - Universitatsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Hansen","sequence":"additional","affiliation":[{"name":"Charit\u00e9 - Universitatsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Grittner","sequence":"additional","affiliation":[{"name":"Charit\u00e9 - Universitatsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Kunze","sequence":"additional","affiliation":[{"name":"Charit\u00e9 - Universitatsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Dietzel","sequence":"additional","affiliation":[{"name":"Institute of Social Medicine, Epidemiology and Health Economics, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Schurig","sequence":"additional","affiliation":[{"name":"Department of Radiology and Neuroradiology, St\u00e4dtisches Klinikum Dresden Friedrichstadt, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Dimitrijeski","sequence":"additional","affiliation":[{"name":"Vivantes Klinikum Neuk\u00f6lln, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Hagemann","sequence":"additional","affiliation":[{"name":"HELIOS Klinikum Berlin-Buch, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Vivantes Auguste Viktoria Klinikum, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Honermann","sequence":"additional","affiliation":[{"name":"Vivantes Klinikum Spandau, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard Jan","family":"Jungehuelsing","sequence":"additional","affiliation":[{"name":"J\u00fcdisches Krankenhaus Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Kauert","sequence":"additional","affiliation":[{"name":"Evangelisches Krankenhaus K\u00f6nigin Elisabeth Herzberge gGmbH, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Christian","family":"Koennecke","sequence":"additional","affiliation":[{"name":"Vivantes Klinikum im Friedrichshain, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno-Marcel","family":"Mackert","sequence":"additional","affiliation":[{"name":"Vivantes Auguste Viktoria Klinikum, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darius G","family":"Nabavi","sequence":"additional","affiliation":[{"name":"Vivantes Klinikum Neuk\u00f6lln, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Schmehl","sequence":"additional","affiliation":[{"name":"BG Klinikum Unfallkrankenhaus Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Sparenberg","sequence":"additional","affiliation":[{"name":"BG Klinikum Unfallkrankenhaus Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Stingele","sequence":"additional","affiliation":[{"name":"German Red Cross Hospital Berlin Kopenick, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Voelzke","sequence":"additional","affiliation":[{"name":"Schlosspark-Klinik GmbH, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Waldschmidt","sequence":"additional","affiliation":[{"name":"Medical Park AG, Amerang, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zeise-Wehry","sequence":"additional","affiliation":[{"name":"HELIOS Klinikum Berlin-Buch, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter U","family":"Heuschmann","sequence":"additional","affiliation":[{"name":"Institute for Clinical Epidemiology and Biometry, University of W\u00fcrzburg, W\u00fcrzburg, Germany"},{"name":"Clinical Trial Center W\u00fcrzburg, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6520-3720","authenticated-orcid":false,"given":"Matthias","family":"Endres","sequence":"additional","affiliation":[{"name":"Center for Stroke Research Berlin, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Charit\u00e9 - Universitatsmedizin Berlin, Berlin, Germany"},{"name":"German Center for Neurodegenerative Diseases 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