{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T17:06:55Z","timestamp":1761239215301,"version":"3.44.0"},"reference-count":30,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"unspecified","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"SysAfib","award":["257888"],"award-info":[{"award-number":["257888"]}]},{"name":"The South-Eastern Norway Health Authority and the Norwegian Research Council","award":["19\/00264-360"],"award-info":[{"award-number":["19\/00264-360"]}]},{"name":"Precision Health Center for optimised Cardiac Care","award":["309762"],"award-info":[{"award-number":["309762"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2024,8,19]]},"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Obstructive sleep apnoea (OSA) can cause left atrial (LA) and left ventricular (LV) remodelling, which is linked to atrial fibrillation (AF). Whether continuous positive airway pressure (CPAP) can reverse LA and LV remodelling in patients with OSA and paroxysmal AF (PAF) has yet to be studied. We assessed the impact of CPAP treatment on LA and LV size and function in patients with OSA and PAF before and after catheter ablation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In a randomised controlled trial, we screened patients with PAF for OSA. We enrolled patients with an Apnoea\u2013Hypopnoea Index \u226515\/hour. The burden of AF was monitored by an implantable loop recorder in all patients. Patients were then randomised to CPAP treatment or standard care. Transthoracic echocardiography was performed at baseline and after 6 and 12 months to assess LV and LA function and remodelling with advanced echocardiographic imaging techniques.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We enrolled 109 patients (63\u00b17 years, body mass index 29.6\u00b14.3, 76% men). 83 patients were scheduled for pulmonary vein isolation (PVI) and 26 for clinical follow-up only. 55 patients were randomised to CPAP and 54 to standard care. The burden of AF decreased significantly in patients who underwent PVI irrespective of treatment with CPAP (p for difference \u22640.001). Patients in the study group had LV ejection fraction (LVEF) and LV global longitudinal strain (GLS) within the normal range, increased LA Volume Index (LAVI), LA volume (by speckle tracking) and decreased LA reservoir strain at baseline. We did not observe any improvement in LVEF, GLS, LAVI, LA volume or LA reservoir strain in either group during the 12 months of follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In patients with PAF and OSA, treatment with CPAP was not associated with reverse LA remodelling within 12 months of follow-up.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2024-002718","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T11:38:48Z","timestamp":1730288328000},"page":"e002718","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Cardiac remodelling in patients with atrial fibrillation and obstructive sleep apnoea"],"prefix":"10.1136","volume":"11","clinical-trial-number":[{"clinical-trial-number":"nct02727192","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6867-5675","authenticated-orcid":false,"given":"Tove Elizabeth Frances","family":"Hunt","sequence":"first","affiliation":[{"name":"Department of Cardiology, Oslo universitetssykehus Hjerte- lunge- og karklinikken, Oslo, Norway"},{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"ProCardio Center for Innovation, Oslo universitetssykehus Rikshospitalet, Oslo, Norway"},{"name":"Department of Otorhinolaryngology, University of Oslo Hospital Rikshospitalet, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunn Marit","family":"Traaen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo universitetssykehus Hjerte- lunge- og karklinikken, Oslo, Norway"},{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"KG Jebsen Center for Cardiac Research, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Aaker\u00f8y","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine, St Olav's Hospital HF, Trondheim, Norway"},{"name":"Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6609-0569","authenticated-orcid":false,"given":"Richard John","family":"Massey","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo universitetssykehus Hjerte- lunge- og karklinikken, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Bendz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo universitetssykehus Hjerte- lunge- og karklinikken, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britt","family":"\u00d8verland","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Lovisenberg Diakonale Hospital, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harriet","family":"Akre","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigurd","family":"Steinshamn","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine, St Olav's Hospital HF, Trondheim, Norway"},{"name":"Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan P\u00e5l","family":"Loennechen","sequence":"additional","affiliation":[{"name":"Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway"},{"name":"Department of Cardiology, Norges teknisk-naturvitenskapelige universitet, Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaspar","family":"Broch","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo universitetssykehus Hjerte- lunge- og karklinikken, Oslo, Norway"},{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"ProCardio Center for Innovation, Oslo universitetssykehus Rikshospitalet, Oslo, Norway"},{"name":"Department of Otorhinolaryngology, University of Oslo Hospital Rikshospitalet, Oslo, Norway"},{"name":"KG Jebsen Center for Cardiac Research, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Helle-Valle","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo universitetssykehus Hjerte- lunge- og karklinikken, Oslo, Norway"},{"name":"ProCardio Center for Innovation, Oslo universitetssykehus Rikshospitalet, Oslo, Norway"},{"name":"Department of Otorhinolaryngology, University of Oslo Hospital Rikshospitalet, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d8yvind Haugen","family":"Lie","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo universitetssykehus Hjerte- lunge- og karklinikken, Oslo, Norway"},{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"ProCardio Center for Innovation, Oslo universitetssykehus Rikshospitalet, Oslo, Norway"},{"name":"Department of Otorhinolaryngology, University of Oslo Hospital Rikshospitalet, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Kristine","family":"Anstensrud","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo universitetssykehus Hjerte- lunge- og karklinikken, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina H","family":"Haugaa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo universitetssykehus Hjerte- lunge- og karklinikken, Oslo, Norway"},{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"ProCardio Center for Innovation, Oslo universitetssykehus Rikshospitalet, Oslo, Norway"},{"name":"Department of Otorhinolaryngology, University of Oslo Hospital Rikshospitalet, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Gullestad","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo universitetssykehus Hjerte- lunge- og karklinikken, Oslo, Norway"},{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"KG Jebsen Center for Cardiac Research, University of 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Effects of CPAP treatment on cardiac structure and function in individuals with obstructive sleep apnea and cardiovascular disease: a prospective 6-month randomised control trial. 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