{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:14:28Z","timestamp":1782947668919,"version":"3.54.5"},"reference-count":18,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"unspecified","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"The Swedish State"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2024,7,5]]},"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To compare long-term cardiovascular (CV) outcomes between men and women with aortic stenosis (AS) undergoing aortic valve replacement (AVR) by the type of valve implant.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The study population consisted of 14 123 non-selected patients with AS undergoing first-time AVR and included in the Swedish Web system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies (SWEDEHEART) registry during 2008\u20132016. Comparisons were made between men and women and type of valve implant (ie, surgical implantation with a mechanical (mSAVR) (n=1 966) or biological valve (bioSAVR) (n=9 801)) or by a transcatheter approach (TAVR) (n=2 356). Outcomes included all-cause mortality, ischaemic stroke, major bleeding, thromboembolic events, heart failure and myocardial infarction, continuously adjusted for significant comorbidities and medical treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In the mSAVR cohort, there were no significant sex differences in any CV events. In the bioSAVR cohort, a higher risk of death (HR: 1.14; 95%\u2009CI: 1.04 to 1.26, p=0.007) and major bleeding (HR: 1.41; 95%\u2009CI: 1.18 to 1.69, p&lt;0.001) was observed in men. In the TAVR cohort, men suffered a higher risk of death (HR: 1.24; 95%\u2009CI: 1.07 to 1.45, p=0.005), major bleeding (HR: 1.35; 95%\u2009CI: 1.00 to 1.82, p=0.022) and thromboembolism (HR: 1.35, 95%\u2009CI: 1.00 to 1.82, p=0.047).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>No significant long-term difference in CV events was noted between men and women undergoing AVR with a mechanical aortic valve. In both the bioSAVR and TAVR cohort, mortality was higher in men who also had an increased incidence of several other CV events.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2024-002725","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T22:35:21Z","timestamp":1721774121000},"page":"e002725","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Sex-specific aspects on prognosis after aortic valve replacement for aortic stenosis: a SWEDEHEART registry study"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6560-169X","authenticated-orcid":false,"given":"Nina","family":"Johnston","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Cardiology, Uppsala University, Uppsala Clinical Research Center, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan K","family":"James","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Cardiology, Uppsala University, Uppsala Clinical Research Center, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Lindhagen","sequence":"additional","affiliation":[{"name":"Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"St\u00e5hle","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Thoracic Surgery, Uppsala University Hospital, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Christersson","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Cardiology, Uppsala University, Uppsala Clinical Research Center, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,7,23]]},"reference":[{"key":"2025081612223490000_11.2.e002725.1","first-page":"561","article-title":"ESC\/EACTS guidelines for the management of valvular heart disease","volume":"62","author":"Beyersdorf","year":"2022","journal-title":"Eur Heart J"},{"key":"2025081612223490000_11.2.e002725.2","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006370","article-title":"Sex differences in the utilization and outcomes of surgical aortic valve replacement for severe aortic stenosis","volume":"6","author":"Chaker","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"2025081612223490000_11.2.e002725.3","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.018816","article-title":"Excess mortality and undertreatment of women with severe aortic stenosis","volume":"10","author":"Tribouilloy","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"2025081612223490000_11.2.e002725.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2019.09.008"},{"key":"2025081612223490000_11.2.e002725.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.09.958"},{"key":"2025081612223490000_11.2.e002725.6","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.198804"},{"key":"2025081612223490000_11.2.e002725.7","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2458-11-450","article-title":"External review and validation of the Swedish national inpatient register","volume":"11","author":"Ludvigsson","year":"2011","journal-title":"BMC Public Health"},{"key":"2025081612223490000_11.2.e002725.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.10.041"},{"key":"2025081612223490000_11.2.e002725.9","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(99)00106-2"},{"key":"2025081612223490000_11.2.e002725.10","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.tcm.2019.11.010","article-title":"Men are from mars, women are from venus: factors responsible for gender differences in outcomes after surgical and trans-catheter aortic valve replacement","volume":"31","author":"Goel","year":"2021","journal-title":"Trends Cardiovasc Med"},{"key":"2025081612223490000_11.2.e002725.11","first-page":"362","article-title":"Prevalence, referral patterns, testing, and surgery in aortic valve disease: leaving women and elderly patients behind?","volume":"16","author":"Bach","year":"2007","journal-title":"J Heart Valve Dis"},{"key":"2025081612223490000_11.2.e002725.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2015.10.026"},{"key":"2025081612223490000_11.2.e002725.13","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/14779072.2023.2186853","article-title":"Heart failure and excess mortality after aortic valve replacement in aortic stenosis","volume":"21","author":"Aziminia","year":"2023","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"2025081612223490000_11.2.e002725.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.07.003"},{"key":"2025081612223490000_11.2.e002725.15","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz835"},{"key":"2025081612223490000_11.2.e002725.16","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1002\/ehf2.14257","article-title":"Heart failure: an update from the last years and a look at the near future","volume":"9","author":"Riccardi","year":"2022","journal-title":"ESC Heart Fail"},{"key":"2025081612223490000_11.2.e002725.17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ejim.2021.03.014","article-title":"Sex-specific differences in the presentation, clinical course, and quality of life of patients with acute venous thromboembolism according to baseline risk factors. Insights from the PREFER in VTE","volume":"88","author":"Giustozzi","year":"2021","journal-title":"Eur J Intern Med"},{"key":"2025081612223490000_11.2.e002725.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.04.016"}],"container-title":["Open Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/openhrt-2024-002725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T19:22:46Z","timestamp":1755372166000},"score":1,"resource":{"primary":{"URL":"https:\/\/openheart.bmj.com\/lookup\/doi\/10.1136\/openhrt-2024-002725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":18,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,7,23]]},"published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1136\/openhrt-2024-002725"],"URL":"https:\/\/doi.org\/10.1136\/openhrt-2024-002725","relation":{},"ISSN":["2053-3624"],"issn-type":[{"value":"2053-3624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]}}}