{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T05:42:15Z","timestamp":1778391735478,"version":"3.51.4"},"reference-count":30,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"unspecified","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2024,7,12]]},"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cardiopulmonary exercise testing (CPET) has an important prognostic value in adults with different congenital heart defects (CHDs) and is a useful tool for risk stratification and clinical decision-making. In this retrospective study, we studied the prognostic value of CPET in paediatric patients with CHD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>411 CPET performed by paediatric patients with different CHDs were evaluated in this retrospective study. Medical records were reviewed to determine the presence of cardiac events. Participants were classified using the 2018 AHA\/ACC guideline for the management of adults with CHD that combines anatomical complexity and current physiological stage.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>411 patients with a median age at test of 12 years, 51 patients with simple CHD, 170 patients with moderate complexity CHD and 190 with high complexity CHD underwent CPET. Overall, CPET parameters were lower than the reference values (%predicted VO<jats:sub>2peak<\/jats:sub>=75% and %predicted oxygen uptake efficiency slope (OUES)=79%), showing worst exercise capacity in the most complex types of CHD (Group III: %predicted VO<jats:sub>2peak<\/jats:sub>=72% and %predicted OUES=75%). Seventy-one patients presented with cardiac events at a median time from CPET to first event of 28 months. Patients with cardiac events had lower exercise performance as compared with patients without cardiac events as determined by the submaximal variables (%predicted OUES: HR=2.6 (1.5\u20134.4), p&lt;0.001\u2009and VE\/VCO<jats:sub>2<\/jats:sub>: HR=2.2 (1.4\u20133.5), p=0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Reduced exercise capacity at young age is related to a higher probability of future cardiovascular events in paediatric patients with CHD. Submaximal exercise variables can be used instead when maximal exercise cannot be achieved.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2024-002820","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T14:05:38Z","timestamp":1724076338000},"page":"e002820","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Prognostic value of cardiopulmonary exercise test in children with congenital heart defects"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8880-1192","authenticated-orcid":false,"given":"Covadonga","family":"Terol","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Division of Paediatric Cardiology, LUMC, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliette","family":"Hagen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Division of Paediatric Cardiology, LUMC, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Rammeloo","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Division of Paediatric Cardiology, Amsterdam UMC Locatie AMC, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene M","family":"Kuipers","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Division of Paediatric Cardiology, Amsterdam UMC Locatie AMC, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolaas A","family":"Blom","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Division of Paediatric Cardiology, LUMC, Leiden, The Netherlands"},{"name":"Department of Paediatrics, Division of Paediatric Cardiology, Amsterdam UMC Locatie AMC, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arend DJ","family":"ten Harkel","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Division of Paediatric Cardiology, LUMC, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"2025081710333589000_11.2.e002820.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.025"},{"key":"2025081710333589000_11.2.e002820.2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-3435"},{"key":"2025081710333589000_11.2.e002820.3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.064400"},{"key":"2025081710333589000_11.2.e002820.4","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwab125"},{"key":"2025081710333589000_11.2.e002820.5","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2018-000812","article-title":"Prognostic power of cardiopulmonary exercise testing in fontan patients: a systematic review","volume":"5","author":"Udholm","year":"2018","journal-title":"Open Heart"},{"key":"2025081710333589000_11.2.e002820.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2021.05.049"},{"key":"2025081710333589000_11.2.e002820.7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.529800"},{"key":"2025081710333589000_11.2.e002820.8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.058719"},{"key":"2025081710333589000_11.2.e002820.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(19)32100-X"},{"key":"2025081710333589000_11.2.e002820.10","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.014988","article-title":"Newly developed adult congenital heart disease anatomic and physiological classification: first predictive validity evaluation","volume":"9","author":"Ombelet","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"2025081710333589000_11.2.e002820.11","unstructured":"Godfrey S . 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