{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T11:34:31Z","timestamp":1773920071695,"version":"3.50.1"},"reference-count":30,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"unspecified","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015993","name":"Kowa Company","doi-asserted-by":"publisher","award":["22FA1016"],"award-info":[{"award-number":["22FA1016"]}],"id":[{"id":"10.13039\/100015993","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2024,11,19]]},"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Hypertension is a risk factor for bleeding events and is included in the HAS-BLED (Hypertension, Abnormal renal\/liver function, Stroke, Bleeding history or predisposition, Labile INR, Elderly, Drugs\/Alcohol concomitantly)<\/jats:p>\n                  <jats:p>score. However, the effects of blood pressure (BP) and changes in BP on bleeding events in patients undergoing percutaneous coronary intervention (PCI) remain poorly understood. This study is aimed to investigate the relationship between systolic BP (SBP) changes during hospitalisation and bleeding events in patients undergoing PCI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>From the Clinical Deep Data Accumulation System database, a multicentre database encompassing seven tertiary medical hospitals in Japan that includes data for patient characteristics, medications, laboratory tests, physiological tests, cardiac catheterisation and PCI treatment, data for 6351 patients undergoing PCI between April 2013 and March 2019 were obtained. The study population was categorised into three groups based on the changes in SBP during hospitalisation: (1) elevated BP (\u226520\u2009mm Hg), (2) no change (\u2265\u221220 to &lt;20\u2009mm Hg) and (3) decreased BP (&lt;\u221220 mm Hg) groups. The primary outcome was a 3-year major bleeding event defined as moderate or severe bleeding according to the Global Use of Streptokinase and t-PA for Occluded Coronary Arteries bleeding criteria.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The elevated BP group exhibited significantly lower SBP at admission and higher SBP at discharge (p&lt;0.001). Multivariable Cox hazard regression models showed that elevated BP was associated with a high risk of bleeding events (HR: 1.885; 95% CI, 1.294 to 2.748). The multivariable logistic regression model identified female sex, chronic coronary syndrome, peripheral artery disease and chronic kidney disease as independent factors associated with elevated BP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These findings suggest that BP management is essential to prevent bleeding events after PCI.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2024-002987","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T03:08:33Z","timestamp":1735009713000},"page":"e002987","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Changes in systolic blood pressure during hospitalisation and bleeding events after percutaneous coronary intervention"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6424-2537","authenticated-orcid":false,"given":"Yasuhiro","family":"Otsuka","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Kumamoto University Hospital, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4137-9136","authenticated-orcid":false,"given":"Masanobu","family":"Ishii","sequence":"additional","affiliation":[{"name":"Kumamoto University, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So","family":"Ikebe","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kumamoto University, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taishi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kumamoto University, Kumamoto, Japan"},{"name":"Department of Medical Information Science, Kumamoto University, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Tsujita","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine, Kumamoto University, Kumamoto, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Matoba","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kyushu University, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahide","family":"Kohro","sequence":"additional","affiliation":[{"name":"Clinical Informatics, Jichi Medical University, Shimotsuke, Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Oba","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Shimotsuke, 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Tokyo Hospital, Bunkyo-ku, Japan"},{"name":"Development Bank of Japan Inc, Chiyoda, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8297-8624","authenticated-orcid":false,"given":"Kotaro","family":"Nochioka","sequence":"additional","affiliation":[{"name":"Cardiovascular medicine, Tohoku University Hospital, Sendai, Miyagi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takamasa","family":"Iwai","sequence":"additional","affiliation":[{"name":"Department of 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