{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:18:44Z","timestamp":1793132324665,"version":"4.5.0"},"reference-count":37,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"unspecified","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2024,12,5]]},"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transcatheter aortic valve replacement (TAVR) is increasingly used for aortic valve replacement instead of surgical aortic valve replacement (sAVR). We aimed to examine the impact of diabetes on 30-day mortality, 30-day readmission and compare outcomes between TAVR and sAVR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were extracted from the Nationwide Readmissions Database from 2012 to 2017. The primary outcome was 30-day mortality, and the secondary outcome was 30-day readmission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 110\u2009135 patients who underwent aortic valve replacement. Of these, 59\u2009466 (54.0%) were hospitalised for TAVR, and 50\u2009669 (46.0%) underwent sAVR. Diabetes was present in 36.4% of TAVR patients and 29.1% of sAVR patients. In TAVR patients, the adjusted risk of 30-day readmission and mortality was similar regardless of diabetes status (aHR=0.94 (0.86\u20131.03); 0.97 (0.84\u20131.12); respectively). However, sAVR patients with diabetes had a higher adjusted risk of 30-day mortality (aHR=1.13 (1.01\u20131.25)) but not readmission (aHR=0.92 (0.84\u20131.01)). When comparing outcomes between TAVR and sAVR in patients with diabetes, TAVR patients were older and had a higher prevalence of chronic kidney disease (CKD). Nevertheless, 30-day readmission and mortality were lower in patients who underwent TAVR (aHR=0.59 (0.53\u20130.67), aHR=0.29 (0.25\u20130.34), respectively) compared with sAVR. Coronary artery disease was the most significant predictor of readmission in patients with diabetes. CKD increased the risk of mortality by almost twofold in both techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Diabetes increases the risk of short-term mortality in sAVR but not TAVR. Moreover, the incidence of 30-day mortality and readmission is lower in TAVR compared with TAVR among patients with diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/openhrt-2024-003019","type":"journal-article","created":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T00:00:35Z","timestamp":1736640035000},"page":"e003019","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Diabetes is associated with a higher incidence of short-term mortality risk and readmission in patients who undergo surgical but not transcatheter aortic valve replacement"],"prefix":"10.1136","volume":"12","author":[{"given":"Ashton","family":"D Souza","sequence":"first","affiliation":[{"name":"Research Department, Weill Cornell Medicine\u2014Qatar, Doha, Qatar"},{"name":"Department of Medicine, Rochester General Hospital, Rochester, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalifa","family":"Bsheish","sequence":"additional","affiliation":[{"name":"Research Department, Weill Cornell Medicine\u2014Qatar, Doha, Qatar"},{"name":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soha","family":"Dargham","sequence":"additional","affiliation":[{"name":"Department of Medical Education, Weill Cornell Medicine \u2013 Qatar, Doha, Qatar"},{"name":"Biostatistics core, Weill Cornell Medicine \u2013 Qatar, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Jayyousi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jassim","family":"Al Suwaidi","sequence":"additional","affiliation":[{"name":"Heart hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1428-6324","authenticated-orcid":false,"given":"Charbel","family":"Abi Khalil","sequence":"additional","affiliation":[{"name":"Research Department, Weill Cornell Medicine\u2014Qatar, Doha, Qatar"},{"name":"Heart hospital, Hamad Medical Corporation, Doha, Qatar"},{"name":"Sanford and I. 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