{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T04:53:58Z","timestamp":1766120038116,"version":"3.48.0"},"reference-count":12,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"unspecified","delay-in-days":170,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2025,5,7]]},"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction and objectives<\/jats:title>\n                    <jats:p>Brugada syndrome (BS) is a channelopathy associated with an increased risk of sudden cardiac death (SCD). Intense physical activity is a recognised trigger of life-threatening arrhythmias in long QT syndrome, catecholaminergic ventricular tachycardia syndrome and arrhythmogenic cardiomyopathy, but it is believed to be safe in BS. The objective of this study is to assess the impact of regular physical activity on the expression and prognosis of BS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>286 consecutive BS patients (aged 39.1\u00b117.8 years old, 70.6% men) were included. Patients were classified according to the level of exercise and main discipline of sport they had practised.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>190 (66.4%) were sedentary, 27 (9.4%) practised light exercise, 59 (20.6%) moderate and 10 (5.3%) intense. Patients engaged in \u2018mixed or endurance\u2019 types of exercise were diagnosed earlier than sedentary ones (HR: 2.1; 95% CI: 1.5 to 2.9; p&lt;0.001) and experienced syncope at a younger age (24.9\u00b116.2 vs 37.4\u00b118.2 years; p=0.04). Physical activity was associated with ECG sport-related changes like bradycardia (\u0394 6 bpm) and a shorter QTc (\u0394 21\u2009ms) and also to a higher ST elevation in right precordial leads (\u0394 0.5\u2009mm). Physical activity was not a predictor of arrhythmic events or SCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Regular physical activity was associated with a younger diagnosis and an earlier occurrence of syncopal episodes. BS patients engaged in \u2018mixed or endurance\u2019 sports have ECG changes associated with sport adaptation and higher ST segment elevation. Nevertheless, physical activity was not related to a higher arrhythmic risk in our cohort of patients with BS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/openhrt-2024-003119","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T04:10:24Z","timestamp":1766117424000},"page":"e003119","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of physical activity on presentation and prognosis of Brugada syndrome"],"prefix":"10.1136","volume":"12","author":[{"given":"Mar\u00eda Jes\u00fas","family":"Fernandez Gil","sequence":"first","affiliation":[{"name":"Unidad de Cardiopatias Familiares. Servicio de Cardiolog\u00eda, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7314-9779","authenticated-orcid":false,"given":"Lidia Mar\u00eda","family":"Carrillo Mora","sequence":"additional","affiliation":[{"name":"Unidad de Cardiopatias Familiares. Servicio de Cardiolog\u00eda, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4306-1447","authenticated-orcid":false,"given":"David","family":"Fernandez Vazquez","sequence":"additional","affiliation":[{"name":"Unidad de Cardiopatias Familiares. Servicio de Cardiolog\u00eda, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Melgarejo","sequence":"additional","affiliation":[{"name":"Universidad Rey Juan Carlos, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3546-4350","authenticated-orcid":false,"given":"Juan Jos\u00e9","family":"Santos Mateo","sequence":"additional","affiliation":[{"name":"Unidad de Cardiopatias Familiares. Servicio de Cardiolog\u00eda, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, Murcia, Spain"},{"name":"Instituto de Salud Carlos III, CIBERCV, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Mu\u00f1oz Esparza","sequence":"additional","affiliation":[{"name":"Unidad de Cardiopatias Familiares. Servicio de Cardiolog\u00eda, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, Murcia, Spain"},{"name":"Instituto de Salud Carlos III, CIBERCV, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0129-6504","authenticated-orcid":false,"given":"Ana Isabel","family":"Rodriguez Serrano","sequence":"additional","affiliation":[{"name":"Unidad de Cardiopatias Familiares. Servicio de Cardiolog\u00eda, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, Murcia, Spain"},{"name":"Instituto de Salud Carlos III, CIBERCV, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Navarro-Penalver","sequence":"additional","affiliation":[{"name":"Unidad de Cardiopatias Familiares. Servicio de Cardiolog\u00eda, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, Murcia, Spain"},{"name":"Instituto de Salud Carlos III, CIBERCV, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Jose","family":"Sanchez Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Unidad de Cardiopatias Familiares. Servicio de Cardiolog\u00eda, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, Murcia, Spain"},{"name":"Instituto de Salud Carlos III, CIBERCV, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco-Javier","family":"Gimeno-Blanes","sequence":"additional","affiliation":[{"name":"Departmento de teoria de la se\u00f1al y las comunicaciones, Universidad Miguel Hernandez, Elche, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1352-1748","authenticated-orcid":false,"given":"Maria","family":"Sabater-Molina","sequence":"additional","affiliation":[{"name":"Instituto de Salud Carlos III, CIBERCV, Madrid, Spain"},{"name":"Laboratorio de Cardiogen\u00e9tica, Instituto Murciano de Investigaci\u00f3n Biosanitaria, Murcia, Spain"},{"name":"Departamento de Medicina Legal y Forense, Universidad de Murcia, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5818-1754","authenticated-orcid":false,"given":"Juan R","family":"Gimeno","sequence":"additional","affiliation":[{"name":"Unidad de Cardiopatias Familiares. Servicio de Cardiolog\u00eda, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, Murcia, Spain"},{"name":"Instituto de Salud Carlos III, CIBERCV, Madrid, Spain"},{"name":"European Reference Network for Raare and Low Prevalent Complex Diseases of the Heart, Delft, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"2025121820101733000_12.2.e003119.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.06.037"},{"key":"2025121820101733000_12.2.e003119.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-8932(09)73082-9"},{"key":"2025121820101733000_12.2.e003119.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000152479.54298.51"},{"key":"2025121820101733000_12.2.e003119.4","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.tcm.2017.11.003","article-title":"Controversies in Brugada syndrome","volume":"28","author":"Cerrone","year":"2018","journal-title":"Trends Cardiovasc Med"},{"key":"2025121820101733000_12.2.e003119.5","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy730"},{"key":"2025121820101733000_12.2.e003119.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2017.06.002"},{"key":"2025121820101733000_12.2.e003119.7","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22386"},{"key":"2025121820101733000_12.2.e003119.8","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.artmed.2018.11.006","article-title":"Recursive model identification for the analysis of the autonomic response to exercise testing in Brugada syndrome","volume":"97","author":"Calvo","year":"2019","journal-title":"Artif Intell Med"},{"key":"2025121820101733000_12.2.e003119.9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.109.862441"},{"key":"2025121820101733000_12.2.e003119.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.06.033"},{"key":"2025121820101733000_12.2.e003119.11","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1055\/s-0043-107240","article-title":"Brugada Syndrome and Exercise Practice: Current Knowledge, Shortcomings and Open Questions","volume":"38","author":"Mascia","year":"2017","journal-title":"Int J Sports Med"},{"key":"2025121820101733000_12.2.e003119.12","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/europace\/euaa106","article-title":"Recommendations for participation in leisure-time physical activity and competitive sports of patients with arrhythmias and potentially arrhythmogenic conditions. Part 2: ventricular arrhythmias, channelopathies, and implantable defibrillators","volume":"23","author":"Heidbuchel","year":"2021","journal-title":"Europace"}],"container-title":["Open Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/openhrt-2024-003119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T04:10:26Z","timestamp":1766117426000},"score":1,"resource":{"primary":{"URL":"https:\/\/openheart.bmj.com\/lookup\/doi\/10.1136\/openhrt-2024-003119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,12,18]]},"published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1136\/openhrt-2024-003119"],"URL":"https:\/\/doi.org\/10.1136\/openhrt-2024-003119","relation":{},"ISSN":["2053-3624"],"issn-type":[{"value":"2053-3624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}