{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T16:55:41Z","timestamp":1755795341842,"version":"3.44.0"},"reference-count":38,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"unspecified","delay-in-days":91,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico - CNPq","award":["165778\/2017-2"],"award-info":[{"award-number":["165778\/2017-2"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior- CAPES","award":["88887.185675\/2018-00","88887.470405\/2019-0"],"award-info":[{"award-number":["88887.185675\/2018-00","88887.470405\/2019-0"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2025,3,7]]},"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>In this randomised two-period crossover trial, the objective was to compare acute changes in arterial distensibility between high-intensity interval physical exercise (HIIPE) and moderate-intensity continuous physical exercise (MICPE) sessions in subjects with elevated blood pressure (BP).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>Participants underwent either MICPE-HIIPE or HIIPE-MICPE sequences with intensity based on cardiopulmonary exercise testing. The main outcome measures included arterial stiffness (by pulse wave velocity (PWV)) at baseline, until 30\u2009min and 24 hours after each physical exercise session. Other measures include office BP, 24-hour ambulatory blood pressure monitoring (ABPM) and applanation tonometry.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The study involved 29 subjects with elevated BP (76% female, 48\u00b17 years, body mass index=28.3\u00b14.3\u2009kg\/m\u00b2, systolic BP=126\u00b19\u2009mm Hg and diastolic BP=84\u00b14\u2009mm Hg). They presented lower PWV 24\u2009hours after MICPE compared with baseline and to 24-hour HIIPE ((\u22120.83 (\u22121.29;\u22120.37) p=0.001) and (\u22120.98 (\u22121.84;\u22120.12), p=0.021), respectively). Despite no differences in office BP, aortic systolic BP was lower after HIIPE compared with baseline and to 24-hour MICPE (113\u00b119; 118\u00b110\u2009and 117\u00b110\u2009mm Hg; p=0.013).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In subjects with elevated BP, arterial distensibility is greater 24 hours after MICPE, while aortic systolic BP is lower after HIIPE. The particularities of each method and each exercise intensity can provide specific mechanisms of vascular response to exercise and detect vascular damage early in these subjects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>\n                     <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT04200716\">NCT04200716<\/jats:ext-link>.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2024-003121","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T19:59:19Z","timestamp":1743623959000},"page":"e003121","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of vascular responses to moderate-intensity continuous and high-intensity interval physical exercise in subjects with elevated blood pressure: a randomised, cross-over clinical trial"],"prefix":"10.1136","volume":"12","clinical-trial-number":[{"clinical-trial-number":"nct04200716","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct04200716","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct04200716","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4998-7534","authenticated-orcid":false,"given":"Sara","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Unidade de Hipertens\u00e3o, Instituto do Cora\u00e7\u00e3o (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Gomes Sanches","family":"Verardino","sequence":"additional","affiliation":[{"name":"Unidade de Hipertens\u00e3o, Instituto do Cora\u00e7\u00e3o (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ria","family":"Costa - Hong","sequence":"additional","affiliation":[{"name":"Unidade de Hipertens\u00e3o, Instituto do Cora\u00e7\u00e3o (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Paixao","family":"Jordao","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo Instituto do Cora\u00e7\u00e3o, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Jose Andrade da Costa","sequence":"additional","affiliation":[{"name":"Unidade de Exerc\u00edcio F\u00edsico e Reabilita\u00e7\u00e3o, Instituto do Cora\u00e7\u00e3o (InCor), Hospital das Clinicas, HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz","family":"Bortolotto","sequence":"additional","affiliation":[{"name":"Unidade de Hipertens\u00e3o, Instituto do Cora\u00e7\u00e3o (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"key":"2025081710223859000_12.1.e003121.1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318061"},{"key":"2025081710223859000_12.1.e003121.2","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1007\/s00421-018-3900-5","article-title":"Effects of exercise intensity and cardiorespiratory fitness on the acute response of arterial stiffness to exercise in older adults","volume":"118","author":"Perissiou","year":"2018","journal-title":"Eur J Appl Physiol"},{"key":"2025081710223859000_12.1.e003121.3","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1161\/HYPERTENSIONAHA.121.18449","article-title":"Effects of Arterial Stiffness and Carotid Intima-Media Thickness Progression on the Risk of Overweight\/Obesity and Elevated Blood Pressure\/Hypertension: a Cross-Lagged Cohort Study","volume":"79","author":"Agbaje","year":"2022","journal-title":"Hypertension"},{"key":"2025081710223859000_12.1.e003121.4","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003480"},{"key":"2025081710223859000_12.1.e003121.5","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000066"},{"key":"2025081710223859000_12.1.e003121.6","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae178"},{"key":"2025081710223859000_12.1.e003121.7","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.112.004473","article-title":"Exercise training for blood pressure: a systematic review and meta-analysis","volume":"2","author":"Cornelissen","year":"2013","journal-title":"J Am Heart Assoc"},{"key":"2025081710223859000_12.1.e003121.8","doi-asserted-by":"crossref","unstructured":"Fraccari-Pires N , Coelho-J\u00fanior HJ , Gambassi BB , et al . 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