{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:33:13Z","timestamp":1790357593067,"version":"4.1.0"},"reference-count":15,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"unspecified","delay-in-days":93,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2025,3,3]]},"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Novel treatments are needed for patients with severely symptomatic obstructive hypertrophic cardiomyopathy (oHCM). Radiofrequency (RF) septal ablation has emerged as a promising technique for improving the left ventricular outflow tract (LVOT) gradient and alleviating symptoms, potentially achieving outcomes comparable to the gold-standard surgical myectomy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To compare the 1-year efficacy and safety of surgical myectomy with RF septal ablation in patients with oHCM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This observational, retrospective cohort study included patients aged\u226518 years with oHCM and an LVOT gradient\u226550\u2009mm Hg, unresponsive to medical therapy, who underwent surgical myectomy or RF septal ablation between 2012 and 2022.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mean age was 49.8\u00b114\u2009and 56.9\u00b110.9 years for the myectomy and RF groups, respectively, with the same sex distribution. The proportions of patients in functional class III distributions were 54.5% and 76.1% in the myectomy and RF groups, respectively. The LVOT gradient was 108.6\u00b149.8\u2009and 101.1\u00b140.3\u2009mm Hg for the myectomy and RF groups, respectively. Procedural success, defined as a reduction in the LVOT gradient to &lt;50\u2009mm Hg or an improvement to functional class I or II, showed no significant difference between the groups (HR: \u22123.5; 95% CI: \u221220.2 to 13.12; p=0.673). Complications occurred in 57.6% and 4.6% of the patients in the myectomy and RF groups, respectively (p&lt;0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>RF septal ablation and surgical myectomy demonstrated similar efficacy in reducing LVOT gradients and improving symptoms. However, RF ablation exhibited a superior safety profile.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2025-003166","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T09:31:51Z","timestamp":1743759111000},"page":"e003166","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy and safety of myectomy and radiofrequency septal ablation for treating hypertrophic obstructive cardiomyopathy"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3799-9466","authenticated-orcid":false,"given":"Larissa Ventura Ribeiro","family":"Bruscky","sequence":"first","affiliation":[{"name":"Instituto Dante Pazzanese de Cardiologia, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Pereira","family":"Valdigem","sequence":"additional","affiliation":[{"name":"Instituto Dante Pazzanese de Cardiologia, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edileide de Barros","family":"Correia","sequence":"additional","affiliation":[{"name":"Instituto Dante Pazzanese de Cardiologia, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Chaccur","sequence":"additional","affiliation":[{"name":"Instituto Dante Pazzanese de Cardiologia, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea de Andrade","family":"Vilela","sequence":"additional","affiliation":[{"name":"Instituto Dante Pazzanese de Cardiologia, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio Tito","family":"Paladino Filho","sequence":"additional","affiliation":[{"name":"Instituto Dante Pazzanese de Cardiologia, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibraim","family":"Pinto","sequence":"additional","affiliation":[{"name":"Instituto Dante Pazzanese de Cardiologia, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui Fernando","family":"Ramos","sequence":"additional","affiliation":[{"name":"Instituto Dante Pazzanese de Cardiologia, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Eduardo","family":"Assef","sequence":"additional","affiliation":[{"name":"Instituto Dante Pazzanese de Cardiologia, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"2025081711040478000_12.1.e003166.1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu284"},{"key":"2025081711040478000_12.1.e003166.2","first-page":"207","article-title":"Diagnosis and Management of Hypertrophic Cardiomyopathy: Updated Guidelines From the ACC\/AHA","volume":"105","author":"Leggit","year":"2022","journal-title":"Am Fam Physician"},{"key":"2025081711040478000_12.1.e003166.3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.018692"},{"key":"2025081711040478000_12.1.e003166.4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.52.1.88"},{"key":"2025081711040478000_12.1.e003166.5","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1016\/j.jacc.2022.03.332","article-title":"Surgical Septal Myectomy and Alcohol Ablation: Not Equivalent in Efficacy or Survival","volume":"79","author":"Sherrid","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2025081711040478000_12.1.e003166.6","first-page":"861","article-title":"Abla\u00e7\u00e3o Septal Com Cateteres e Radiofrequ\u00eancia Guiada Pela Ecocardiografia Para Tratamento de Pacientes Com Cardiomiopatia Hipertr\u00f3fica Obstrutiva: Experi\u00eancia Inicial. Septal Ablation with Radiofrequency Catheters Guided by Echocardiography for Treatment of Patients with Obstructive Hypertrophic Cardiomyopathy: Initial Experience","volume":"118","author":"Valdigem","year":"2022","journal-title":"Arq Bras Cardiol"},{"key":"2025081711040478000_12.1.e003166.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.04.048"},{"key":"2025081711040478000_12.1.e003166.8","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1016\/j.jtcvs.2018.11.148","article-title":"Surgical management of left ventricular outflow tract obstruction in a specialized hypertrophic obstructive cardiomyopathy center","volume":"157","author":"Hodges","year":"2019","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2025081711040478000_12.1.e003166.9","doi-asserted-by":"crossref","first-page":"353","DOI":"10.21037\/acs.2017.07.07","article-title":"Results of surgical septal myectomy for obstructive hypertrophic cardiomyopathy: the Tufts experience","volume":"6","author":"Rastegar","year":"2017","journal-title":"Ann Cardiothorac Surg"},{"key":"2025081711040478000_12.1.e003166.10","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.ihj.2016.02.007","article-title":"A novel approach in the use of radiofrequency catheter ablation of septal hypertrophy in hypertrophic obstructive cardiomyopathy","volume":"68","author":"Shelke","year":"2016","journal-title":"Indian Heart J"},{"key":"2025081711040478000_12.1.e003166.11","doi-asserted-by":"crossref","first-page":"e1239","DOI":"10.1161\/CIR.0000000000001250","article-title":"2024 AHA\/ACC\/AMSSM\/HRS\/PACES\/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy: A Report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines","volume":"149","author":"Ommen","year":"2024","journal-title":"Circulation"},{"key":"2025081711040478000_12.1.e003166.12","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.034080","article-title":"Midterm Outcomes of Percutaneous Intramyocardial Septal Radiofrequency Ablation for Hypertrophic Cardiomyopathy: A Single-Center, Observational Study","volume":"13","author":"Xie","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"2025081711040478000_12.1.e003166.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.02.010"},{"key":"2025081711040478000_12.1.e003166.14","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/clc.23341","article-title":"Efficacy and safety of radiofrequency ablation for hypertrophic obstructive cardiomyopathy: A systematic review and meta-analysis","volume":"43","author":"Yang","year":"2020","journal-title":"Clin Cardiol"},{"key":"2025081711040478000_12.1.e003166.15","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1016\/j.hrthm.2016.04.018","article-title":"Radiofrequency septal reduction in symptomatic hypertrophic obstructive cardiomyopathy","volume":"13","author":"Crossen","year":"2016","journal-title":"Heart Rhythm"}],"container-title":["Open Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/openhrt-2025-003166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T18:04:13Z","timestamp":1755453853000},"score":1,"resource":{"primary":{"URL":"https:\/\/openheart.bmj.com\/lookup\/doi\/10.1136\/openhrt-2025-003166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,4,4]]},"published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1136\/openhrt-2025-003166"],"URL":"https:\/\/doi.org\/10.1136\/openhrt-2025-003166","relation":{},"ISSN":["2053-3624"],"issn-type":[{"value":"2053-3624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]}}}