{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T03:10:15Z","timestamp":1770433815082,"version":"3.49.0"},"reference-count":13,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"unspecified","delay-in-days":36,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019717","name":"AstraZeneca Espa\u00f1a","doi-asserted-by":"publisher","award":["This study was funded by an unrestricted grant fro"],"award-info":[{"award-number":["This study was funded by an unrestricted grant fro"]}],"id":[{"id":"10.13039\/100019717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2025,7,23]]},"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Heart failure (HF) often coexists with chronic kidney disease (CKD), impacting prognosis. This study aims to evaluate renal function trajectories and their impact on major clinical outcomes in a cohort of patients hospitalised for \u2018de novo\u2019 HF with reduced ejection fraction (HFrEF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a prospective cohort study that included patients hospitalised for \u2018de novo\u2019 HFrEF at two university hospitals. Renal function was assessed using the CKD-Epidemiology Collaboration formula. Total mortality and the combined total mortality and HF readmissions were evaluated during follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 370 patients, 306 were eligible. At discharge, 24.6% had estimated glomerular filtration rate (eGFR) &lt;45\u2009mL\/min\/1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      . Higher eGFR at discharge was associated with better outcomes. During follow-up, 79.1% showed eGFR \u226545\u2009mL\/min\/1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      . Patients with stable or improved eGFR had lower total mortality and HF readmission rates. Factors associated with renal function improvement or stabilisation included less prior CKD, hypertension and younger age, higher eGFR values at discharge and more use of quadruple therapy at the end of uptitration period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with \u2018de novo\u2019 HFrEF, renal function deterioration at discharge correlated with poorer outcomes. However, stabilisation or improvement during follow-up was linked to better prognosis. Routine renal function assessment is crucial in HFrEF management, guiding personalised treatment strategies to mitigate renal function decline and improve patient care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/openhrt-2025-003193","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T13:27:02Z","timestamp":1770384422000},"page":"e003193","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Renal function trajectories in \u2018De Novo\u2019 heart failure with reduced ejection fraction: impact on outcomes"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9292-518X","authenticated-orcid":false,"given":"Oscar","family":"Otero Garcia","sequence":"first","affiliation":[{"name":"Cardiology Department, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edctor","family":"Donoso Trenado","sequence":"additional","affiliation":[{"name":"La Fe University and Polytechnic Hospital, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"de la Fuente-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Cardiology Department, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"L\u00f3pez Vilella","sequence":"additional","affiliation":[{"name":"La Fe University and Polytechnic Hospital, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Adarraga-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Cardiology Department, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Yebra Pimentel-Brea","sequence":"additional","affiliation":[{"name":"Cardiology Department, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Gallego-Latorre","sequence":"additional","affiliation":[{"name":"Cardiology Department, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda In\u00e9s","family":"G\u00f3mez-Otero","sequence":"additional","affiliation":[{"name":"University Hospital of Santiago de Compostela Servicio de Cardiolog\u00eda, Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noelia","family":"Bouzas Cruz","sequence":"additional","affiliation":[{"name":"Cardiology, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK"},{"name":"Doctorate student of University of Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Garcia-Vega","sequence":"additional","affiliation":[{"name":"Cardiology Department, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Almenar Bonet","sequence":"additional","affiliation":[{"name":"La Fe University and Polytechnic Hospital, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Ramon","family":"Gonzalez Juanatey","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital of Santiago de Compostela Servicio de Cardiolog\u00eda, Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"2026020605251278000_13.1.e003193.1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp507"},{"key":"2026020605251278000_13.1.e003193.2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht386"},{"key":"2026020605251278000_13.1.e003193.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.11.084"},{"key":"2026020605251278000_13.1.e003193.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2007.04.008"},{"key":"2026020605251278000_13.1.e003193.5","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp108"},{"key":"2026020605251278000_13.1.e003193.6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.111.963413"},{"key":"2026020605251278000_13.1.e003193.7","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab670"},{"key":"2026020605251278000_13.1.e003193.8","doi-asserted-by":"publisher","DOI":"10.1016\/J.KINT.2023.10.018"},{"key":"2026020605251278000_13.1.e003193.9","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1002\/jcu.23265","article-title":"Cardiorenal syndrome: Pathophysiology as a key to the therapeutic approach in an under-diagnosed disease","volume":"50","author":"Prastaro","year":"2022","journal-title":"J Clin Ultrasound"},{"key":"2026020605251278000_13.1.e003193.10","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12186105","article-title":"Heart Failure in Patients with Chronic Kidney Disease","volume":"12","author":"Xanthopoulos","year":"2023","journal-title":"J Clin Med"},{"key":"2026020605251278000_13.1.e003193.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.05.002"},{"key":"2026020605251278000_13.1.e003193.12","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/ejhf.2471","article-title":"Renal effects of guideline\u2010directed medical therapies in heart failure: a consensus document from the Heart Failure Association of the European Society of Cardiology","volume":"24","author":"Mullens","year":"2022","journal-title":"European J of Heart Fail"},{"key":"2026020605251278000_13.1.e003193.13","first-page":"849","article-title":"Trajectories of Kidney Function in Heart Failure Over a 15-Year Follow-Up","volume":"12","author":"Zamora","year":"2024","journal-title":"JACC: Heart Failure"}],"container-title":["Open Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/openhrt-2025-003193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T13:27:03Z","timestamp":1770384423000},"score":1,"resource":{"primary":{"URL":"https:\/\/openheart.bmj.com\/lookup\/doi\/10.1136\/openhrt-2025-003193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,2,6]]},"published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1136\/openhrt-2025-003193"],"URL":"https:\/\/doi.org\/10.1136\/openhrt-2025-003193","relation":{},"ISSN":["2053-3624"],"issn-type":[{"value":"2053-3624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]}}}