{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:39:10Z","timestamp":1791509950823,"version":"4.3.4"},"reference-count":34,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"unspecified","delay-in-days":162,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Abbott","award":["NCT03505801"],"award-info":[{"award-number":["NCT03505801"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2025,5,27]]},"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The detection of atrial fibrillation (AF) after a cryptogenic stroke (CS) carries important therapeutic implications. In this study, we aimed to accurately assess the incidence of AF among CS subjects by using an insertable cardiac monitor (ICM).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A prospective, single-arm, multicentre registry was conducted to identify AF in 155 CS subjects using the Confirm Rx ICM (Abbott, California, USA) across 20 global sites. Inclusion criteria comprised participants aged 40 years or older who had experienced CS within a 90-day window. At each follow-up visit, expert electrophysiologists reviewed and adjudicated ICM detected AF episodes. The primary endpoint was the cumulative incidence of true device-detected AF (lasting more than 30\u2009s) at 6 months, evaluated with Kaplan-Meier methods.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>AF incidence was 21.3% (95% CI 15.3% to 29.1%) at 6 months, increasing to 48.8% (95% CI 34.7% to 64.9%) at 24 months. Subjects with AF detection experienced an average of 50.9 true AF episodes per subject per year. The median time from implantation to AF detection (&gt;30\u2009s) was 72 days (IQR 7\u2013261). Among subjects with 30\u2009s AF detection, anticoagulation therapy was initiated in 65.2% (30\/46) of subjects. Oral anticoagulation medication was prescribed in 8.3% (9\/109) of subjects without AF. Recurrent ischaemic stroke or transient ischaemic attack occurred in 5 subjects (3.2%, 5\/155).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>These results show that ICM-driven long-term continuous AF monitoring is associated with high diagnostic yield in CS subjects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>\n                     <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT03505801\">NCT03505801<\/jats:ext-link>\n                  <\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2025-003242","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:21Z","timestamp":1749772821000},"page":"e003242","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Continuing evaluation of atrial fibrillation detection after cryptogenic stroke: 2-year findings from a multicentre study with Confirm Rx ICM"],"prefix":"10.1136","volume":"12","clinical-trial-number":[{"clinical-trial-number":"nct03505801","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3895-9858","authenticated-orcid":false,"given":"Fabio","family":"Quartieri","sequence":"first","affiliation":[{"name":"Arcispedale Santa Maria Nuova di Reggio Emilia, Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6086-0446","authenticated-orcid":false,"given":"Yong-Soo","family":"Baek","sequence":"additional","affiliation":[{"name":"Cardiology, Inha University Hospital, Incheon, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6996-2476","authenticated-orcid":false,"given":"Jong-Sung","family":"Park","sequence":"additional","affiliation":[{"name":"Dong-A University, Busan, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4200-3456","authenticated-orcid":false,"given":"Tae-Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Yonsei University College of Medicine, Seodaemun-gu, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunari","family":"Honma","sequence":"additional","affiliation":[{"name":"Seirei Hamamatsu General Hospital, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Yokohamashintoshi Neurosurgical Hospital, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1361-0022","authenticated-orcid":false,"given":"Ki-Woon","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, College of Medicine, Chung Ang University Hospital, Seoul, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6846-3382","authenticated-orcid":false,"given":"Lin","family":"Feng","sequence":"additional","affiliation":[{"name":"Abbott, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9286-2565","authenticated-orcid":false,"given":"Kwangdeok","family":"Lee","sequence":"additional","affiliation":[{"name":"Abbott, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6204-8745","authenticated-orcid":false,"given":"Andrea","family":"Grammatico","sequence":"additional","affiliation":[{"name":"Abbott, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7246-8954","authenticated-orcid":false,"given":"Lukas","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Asklepios Klinik St Georg, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"key":"2025081710484868000_12.1.e003242.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1503946"},{"key":"2025081710484868000_12.1.e003242.2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"2025081710484868000_12.1.e003242.3","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000375"},{"key":"2025081710484868000_12.1.e003242.4","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)70027-X"},{"key":"2025081710484868000_12.1.e003242.5","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/suaa179"},{"key":"2025081710484868000_12.1.e003242.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105575"},{"key":"2025081710484868000_12.1.e003242.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2023.09.009"},{"key":"2025081710484868000_12.1.e003242.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311376"},{"key":"2025081710484868000_12.1.e003242.9","first-page":"1261","article-title":"Cryptogenic stroke and atrial fibrillation","volume":"371","author":"Sanna","year":"2014","journal-title":"N Engl J Med"},{"key":"2025081710484868000_12.1.e003242.10","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25886"},{"key":"2025081710484868000_12.1.e003242.11","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001193"},{"key":"2025081710484868000_12.1.e003242.12","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euac144"},{"key":"2025081710484868000_12.1.e003242.13","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14076"},{"key":"2025081710484868000_12.1.e003242.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.06.039"},{"key":"2025081710484868000_12.1.e003242.15","doi-asserted-by":"crossref","DOI":"10.1093\/europace\/euad212","article-title":"Insertable cardiac monitoring results in higher rates of atrial fibrillation diagnosis and oral anticoagulation prescription after ischaemic stroke","volume":"25","author":"Boriani","year":"2023","journal-title":"Europace"},{"key":"2025081710484868000_12.1.e003242.16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2303062"},{"key":"2025081710484868000_12.1.e003242.17","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(24)00475-7"},{"key":"2025081710484868000_12.1.e003242.18","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01698-6"},{"key":"2025081710484868000_12.1.e003242.19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2310234"},{"key":"2025081710484868000_12.1.e003242.20","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.115.003333","article-title":"Uncovering Atrial Fibrillation Beyond Short-Term Monitoring in Cryptogenic Stroke Patients: Three-Year Results From the Cryptogenic Stroke and Underlying Atrial Fibrillation Trial","volume":"9","author":"Brachmann","year":"2016","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2025081710484868000_12.1.e003242.21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/cvr\/cvab147","article-title":"Optimizing indices of atrial fibrillation susceptibility and burden to evaluate atrial fibrillation severity, risk and outcomes","volume":"117","author":"Boriani","year":"2021","journal-title":"Cardiovasc Res"},{"key":"2025081710484868000_12.1.e003242.22","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.047633"},{"key":"2025081710484868000_12.1.e003242.23","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000057981.70380.45"},{"key":"2025081710484868000_12.1.e003242.24","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht491"},{"key":"2025081710484868000_12.1.e003242.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.hroo.2022.02.006"},{"key":"2025081710484868000_12.1.e003242.26","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.025169"},{"key":"2025081710484868000_12.1.e003242.27","article-title":"Correction to: Searching for Atrial Fibrillation Poststroke: A White Paper of the AF-SCREEN International Collaboration","volume":"141","year":"2020","journal-title":"Circulation"},{"key":"2025081710484868000_12.1.e003242.28","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac020"},{"key":"2025081710484868000_12.1.e003242.29","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euab036"},{"key":"2025081710484868000_12.1.e003242.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2021.05.038"},{"key":"2025081710484868000_12.1.e003242.31","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaa139"},{"key":"2025081710484868000_12.1.e003242.32","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euac092"},{"key":"2025081710484868000_12.1.e003242.33","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euab324"},{"key":"2025081710484868000_12.1.e003242.34","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euab186"}],"container-title":["Open Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/openhrt-2025-003242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T17:48:59Z","timestamp":1755452939000},"score":1,"resource":{"primary":{"URL":"https:\/\/openheart.bmj.com\/lookup\/doi\/10.1136\/openhrt-2025-003242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,6,12]]},"published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1136\/openhrt-2025-003242"],"URL":"https:\/\/doi.org\/10.1136\/openhrt-2025-003242","relation":{},"ISSN":["2053-3624"],"issn-type":[{"value":"2053-3624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]}}}