{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:37:18Z","timestamp":1793723838727,"version":"4.6.1"},"reference-count":29,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"unspecified","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2025,8,12]]},"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Stroke volume is an established echocardiographic marker but has not been widely studied in patients with ST-segment elevation myocardial infarction (STEMI). We aimed to evaluate stroke volume in a cohort of uncomplicated anterior STEMI and to assess its prognostic role in those with severe left ventricle (LV) systolic dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This is a single-centre retrospective analysis of consecutive patients presenting with anterior STEMI who underwent uncomplicated primary percutaneous coronary intervention. Stroke volume was measured using echocardiography within in-hospital admission. The primary endpoint was cardiovascular mortality. Of 3592 patients with STEMI, 616 were included. The mean age was 65\u00b114 years (76% males). The average left ventricular ejection fraction (LVEF) and stroke volume were 39\u00b111% and 62\u00b118\u2009mL, respectively. There was a modest relationship between stroke volume and LVEF (r=0.33, p&lt;0.001), which was not maintained in patients with severe LV dysfunction (r=0.11, p=0.19). On multivariate analysis, stroke volume was associated with cardiovascular death at 12 months (HR 0.92, 95% CI 0.86 to 0.98, p=0.015) in patients with severe LV systolic dysfunction. Receiver operating characteristic analysis demonstrated an area under the curve of 0.80 (95% CI 0.70 to 0.91, p&lt;0.001) in this group with negative predictive value of 99% for cardiovascular mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Stroke volume is a readily and useful echocardiographic marker to assess prognosis in patients with anterior STEMI and severe LV systolic dysfunction. It identifies with a high degree of certainty those patients who are likely to survive despite their severe LV systolic dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/openhrt-2025-003429","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T13:30:15Z","timestamp":1757079015000},"page":"e003429","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Role of stroke volume in patients presenting with uncomplicated anterior STEMI"],"prefix":"10.1136","volume":"12","author":[{"given":"Muntaser","family":"Omari","sequence":"first","affiliation":[{"name":"Freeman Hospital Cardiothoracic Centre, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"James","sequence":"additional","affiliation":[{"name":"Freeman Hospital Cardiothoracic Centre, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Brown","sequence":"additional","affiliation":[{"name":"Freeman Hospital Cardiothoracic Centre, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadhim","family":"Kadhim","sequence":"additional","affiliation":[{"name":"Freeman Hospital Cardiothoracic Centre, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal","family":"Bawamia","sequence":"additional","affiliation":[{"name":"Freeman Hospital Cardiothoracic Centre, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"McDiarmid","sequence":"additional","affiliation":[{"name":"Freeman Hospital Cardiothoracic Centre, Newcastle upon Tyne, 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