{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T06:31:40Z","timestamp":1780986700353,"version":"3.54.1"},"reference-count":37,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"unspecified","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016061","name":"Stichting de Drie Lichten","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","award":["Educational Grant"],"award-info":[{"award-number":["Educational Grant"]}],"id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001722","name":"Koninklijke Nederlandse Akademie van Wetenschappen","doi-asserted-by":"publisher","award":["Ter Meulen Grant"],"award-info":[{"award-number":["Ter Meulen Grant"]}],"id":[{"id":"10.13039\/501100001722","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005039","name":"Leids Universitair Medisch Centrum","doi-asserted-by":"publisher","award":["Research Council Cardio-Vascular cluster Themes fo"],"award-info":[{"award-number":["Research Council Cardio-Vascular cluster Themes fo"]}],"id":[{"id":"10.13039\/501100005039","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2025,6,30]]},"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Systemic right ventricle (sRV) patients are at an increased risk of developing heart failure. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) could be a valuable treatment option. This study investigated the changes in ventricular function in sRV failure patients in the first year after starting SGLT2i.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult sRV patients from the international, real-world ACHIEVE-SGLT2i registry were included if they had a clinical diagnosis of sRV failure, a transthoracic echocardiogram before starting SGLT2i, and at least one in the first year after starting available for analysis. The primary outcomes were changes in sRV global longitudinal strain (GLS) and fractional area change (FAC). Longitudinal changes were evaluated using linear mixed models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-nine sRV failure patients (46\u00b19.3 years old, 41% female) were included. Twenty-five (64%) had transposition of the great arteries after an atrial switch procedure and 14 (36%) had congenitally corrected transposition. sRV GLS improved significantly in the first 50 days (\u22121.4%-point per month, p&lt;0.001) and stabilised afterwards (&lt;0.1%-point per month, p=0.520). Though age had a significant overall negative effect on sRV GLS (0.1%-point per year of age, p=0.049), it did not influence the longitudinal changes after starting SGLT2i. sRV FAC also improved in the first 50 days (3.2%-point per month, p=0.002), after which sRV FAC deteriorated in patients with subpulmonary left ventricular pacing (\u22120.9%-point per month, p=0.012) while it stabilised in patients without pacing (0.1%-point per month, p=0.573). In the first 50 days, tricuspid annular plane systolic excursion also improved significantly in all patients (1.2\u2009mm per month, p=0.006), and stabilised afterwards (p=0.721).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SGLT2i therapy is associated with improvements in systolic ventricular function in sRV failure patients. Despite early improvement in sRV FAC, there was a negative longer term correlation with subpulmonary left ventricular pacing, potentially reflecting adverse effects of subpulmonary ventricular pacing on sRV function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/openhrt-2025-003445","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T05:35:22Z","timestamp":1753162522000},"page":"e003445","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of sodium-glucose cotransporter 2 inhibitors on ventricular function in systemic right ventricular failure"],"prefix":"10.1136","volume":"12","clinical-trial-number":[{"clinical-trial-number":"nct06932081","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3845-1678","authenticated-orcid":false,"given":"Ralph ML","family":"Neijenhuis","sequence":"first","affiliation":[{"name":"Center for Congenital Heart Disease Amsterdam-Leiden (CAHAL), Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madelien V","family":"Regeer","sequence":"additional","affiliation":[{"name":"Center for Congenital Heart Disease Amsterdam-Leiden (CAHAL), Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niki L","family":"Walker","sequence":"additional","affiliation":[{"name":"Scottish Adult Congenital Cardiac Service (SACCS), Golden Jubilee University National Hospital, Clydebank, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart JA","family":"Mertens","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Hunter","sequence":"additional","affiliation":[{"name":"Scottish Adult Congenital Cardiac Service (SACCS), Golden Jubilee University National Hospital, Clydebank, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippine","family":"Ki\u00e8s","sequence":"additional","affiliation":[{"name":"Center for Congenital Heart Disease Amsterdam-Leiden (CAHAL), Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorna","family":"Swan","sequence":"additional","affiliation":[{"name":"Scottish Adult Congenital Cardiac Service (SACCS), Golden Jubilee University National Hospital, Clydebank, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert W","family":"Vliegen","sequence":"additional","affiliation":[{"name":"Center for Congenital Heart Disease Amsterdam-Leiden (CAHAL), Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9940-1186","authenticated-orcid":false,"given":"Simon T","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Wales, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6730-4955","authenticated-orcid":false,"given":"Filip","family":"Zemrak","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, St Bartholomew\u2019s Hospital, London, UK"},{"name":"Institute of Cardiovascular Science, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8255-1591","authenticated-orcid":false,"given":"Ali N","family":"Zaidi","sequence":"additional","affiliation":[{"name":"Mount Sinai Adult Congenital Heart Disease Center, Mount Sinai Fuster Heart Hospital, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari M","family":"Cedars","sequence":"additional","affiliation":[{"name":"Divisions of Pediatric and Adult Cardiology, Johns Hopkins University, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9132-0418","authenticated-orcid":false,"given":"Monique RM","family":"Jongbloed","sequence":"additional","affiliation":[{"name":"Center for Congenital Heart Disease Amsterdam-Leiden (CAHAL), Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Department of Cardiology, Leiden University Medical Center, Leiden, The 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