{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T09:29:50Z","timestamp":1765704590462,"version":"3.48.0"},"reference-count":82,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"unspecified","delay-in-days":148,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32HL105324"],"award-info":[{"award-number":["T32HL105324"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2025,11,7]]},"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Left ventricular mass (LVM) is suggested to be a sensitive predictor of adverse cardiovascular outcomes, such as heart failure. In recent years, genome-wide association studies have discovered loci that associate with outcomes related to LVM, providing an opportunity for the development of genetic risk scores. However, the relevance of these genetic variants to non-European ancestry groups requires additional testing. Here, we examined if variants that have been associated with heart failure and LVM in multi-ancestry populations are associated with LVM among African American individuals in the Jackson Heart Study (JHS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Heart failure and LVM associated variants were identified from two published multi-ancestry studies. Two polygenic risk scores (PRSs) were computed for 2175 African American participants (mean age 53, 63% female). We assessed the linear association of both PRSs with LVM indexed to height (LVM\n                      <jats:sub>h<\/jats:sub>\n                      ) and indexed to body surface area (LVM\n                      <jats:sub>bsa<\/jats:sub>\n                      ) and fit a multivariate general linear model to LVM containing both PRS and covariates (age, sex, body mass index (BMI), diabetes and hypertension). Type III MANOVA Pillai tests were run to assess the effects of the PRS on the log LVM values.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Linear correlation analysis showed positive associations between age and LVM\n                      <jats:sub>h<\/jats:sub>\n                      (\n                      <jats:italic>r<\/jats:italic>\n                      =0.278) and LVM\n                      <jats:sub>bsa<\/jats:sub>\n                      (\n                      <jats:italic>r<\/jats:italic>\n                      =0.296) as well as BMI with LVM\n                      <jats:sub>h<\/jats:sub>\n                      (\n                      <jats:italic>r<\/jats:italic>\n                      =0.320). A strong linear correlation was observed between LVM\n                      <jats:sub>h<\/jats:sub>\n                      and LVM\n                      <jats:sub>bsa<\/jats:sub>\n                      (\n                      <jats:italic>r<\/jats:italic>\n                      =0.894). Elevated LVM among individuals with diabetes and hypertension was observed. When accounting for age, sex, BMI, diabetes and hypertension, we found insufficient evidence to suggest that the heart failure PRS affected either measure of LVM; the same can be said for the LVM PRS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We find insufficient evidence to suggest that heart failure and LVM genetic variants derived from predominantly European multi-ancestry populations are linearly associated with log LVM among African American participants in the JHS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/openhrt-2025-003501","type":"journal-article","created":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T09:24:55Z","timestamp":1765704295000},"page":"e003501","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of left ventricular mass for African American individuals using multi-ancestry polygenic risk scores: the Jackson Heart Study"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4113-3419","authenticated-orcid":false,"given":"Douglas","family":"McLaurin","sequence":"first","affiliation":[{"name":"The University of Mississippi Medical Center, Jackson, Mississippi, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Turk","sequence":"additional","affiliation":[{"name":"Northeast Ohio Medical University, Rootstown, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Affuso","sequence":"additional","affiliation":[{"name":"Council on Black Health, Knightdale, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura M","family":"Raffield","sequence":"additional","affiliation":[{"name":"Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Heitman","sequence":"additional","affiliation":[{"name":"The University of Texas Southwestern Medical Center, Dallas, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"2025112721051741000_12.2.e003501.1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.25.2981"},{"key":"2025112721051741000_12.2.e003501.2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1000974"},{"key":"2025112721051741000_12.2.e003501.3","doi-asserted-by":"crossref","first-page":"H632","DOI":"10.1152\/ajpheart.00233.2020","article-title":"Stimulus-specific functional remodeling of the left ventricle in endurance and resistance-trained men","volume":"319","author":"Dawkins","year":"2020","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"2025112721051741000_12.2.e003501.4","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.36.10.981"},{"key":"2025112721051741000_12.2.e003501.5","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(75)90013-2"},{"key":"2025112721051741000_12.2.e003501.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005313222203"},{"key":"2025112721051741000_12.2.e003501.7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135883","article-title":"Age-Related Left Ventricular Changes and Their Association with Leukocyte Telomere Length in Healthy People","volume":"10","author":"Akasheva","year":"2015","journal-title":"PLoS One"},{"key":"2025112721051741000_12.2.e003501.8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0224104","article-title":"Echocardiography overestimates LV mass in the elderly as compared to cardiac CT","volume":"14","author":"Stokar","year":"2019","journal-title":"PLoS ONE"},{"key":"2025112721051741000_12.2.e003501.9","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1161\/HYPERTENSIONAHA.121.17109","article-title":"Is Height2.7 Appropriate for Indexation of Left Ventricular Mass in Healthy Adolescents? 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