{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:58:22Z","timestamp":1790236702899,"version":"4.1.0"},"reference-count":41,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"unspecified","delay-in-days":101,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2025,9,2]]},"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Revised haemodynamic criteria for pulmonary hypertension (PH)\u2014mean pulmonary artery pressure (mPAP) &gt;20 mm Hg and pulmonary vascular resistance (PVR) &gt;2 Wood Units (WU)\u2014have defined new subsets of patients with mild PH. We aimed to characterise their clinical profile and prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included consecutive incident, treatment-na\u00efve patients undergoing right heart catheterisation at a PH referral centre. Patients with mPAP 21\u201324\u2009mm Hg and pulmonary artery wedge pressure (PAWP) \u226415\u2009mm Hg were stratified by PVR values to identify those with unclassified PH (PVR\u22642\u2009WU) and mild precapillary PH (PVR&gt;2\u2009WU). Patients with mild precapillary PH were compared with matched controls with normal haemodynamics and with patients meeting previous pulmonary arterial hypertension (PAH) haemodynamic criteria (mPAP\u226525\u2009mm Hg, PAWP\u226415\u2009mm Hg, PVR&gt;3\u2009WU).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 259\u2009patients with mPAP 21\u201324\u2009mm Hg and PAWP\u226415\u2009mm Hg, 76% had left heart or lung disease. In unclassified PH, mPAP elevation was mainly due to high stroke volume index (SVI) or backward transmission from borderline PAWP. In mild precapillary PH, SVI was the only independent haemodynamic predictor of survival. Survival was similar between mild precapillary PH and PAH patients. A limited number of patients with PAH risk factors progressed to overt PAH and, in the absence of comorbidities, appeared to benefit from PAH therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Unclassified PH is mainly related to pulmonary overflow or backward transmission from borderline PAWP. Mild precapillary PH is typically associated with comorbidities and not necessarily an early PAH stage. SVI is a key prognostic marker. Careful clinical phenotyping is essential to identify the small subset who may benefit from targeted therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/openhrt-2025-003591","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T10:50:49Z","timestamp":1760093449000},"page":"e003591","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Phenotyping of patients with mild pulmonary hypertension"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9611-6021","authenticated-orcid":false,"given":"Fabio","family":"Dardi","sequence":"first","affiliation":[{"name":"Cardiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Bertozzi","sequence":"additional","affiliation":[{"name":"Dipartimento DIMEC (Dipartimento di scienze mediche e chirurgiche), Alma Mater Studiorum University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Ballerini","sequence":"additional","affiliation":[{"name":"Dipartimento DIMEC (Dipartimento di scienze mediche e chirurgiche), Alma Mater Studiorum University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cennerazzo","sequence":"additional","affiliation":[{"name":"Dipartimento DIMEC (Dipartimento di scienze mediche e chirurgiche), Alma Mater Studiorum University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3005-8994","authenticated-orcid":false,"given":"Federico","family":"Donato","sequence":"additional","affiliation":[{"name":"Dipartimento DIMEC (Dipartimento di scienze mediche e chirurgiche), Alma Mater Studiorum University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Guarino","sequence":"additional","affiliation":[{"name":"Dipartimento DIMEC (Dipartimento di scienze mediche e chirurgiche), Alma Mater Studiorum University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Manes","sequence":"additional","affiliation":[{"name":"Cardiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4245-912X","authenticated-orcid":false,"given":"Elena","family":"Nardi","sequence":"additional","affiliation":[{"name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Palazzini","sequence":"additional","affiliation":[{"name":"Cardiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy"},{"name":"Dipartimento DIMEC (Dipartimento di scienze mediche e chirurgiche), Alma Mater Studiorum University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazzareno","family":"Gali\u00e9","sequence":"additional","affiliation":[{"name":"Cardiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy"},{"name":"Dipartimento DIMEC (Dipartimento di scienze mediche e chirurgiche), Alma Mater Studiorum University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"2026010701110453000_12.2.e003591.1","unstructured":"Hatano S , Strasser T . 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