{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T18:45:48Z","timestamp":1785782748080,"version":"3.56.0"},"reference-count":15,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"unspecified","delay-in-days":183,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2025,11,18]]},"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Constrictive pericarditis (CP) is a rare but significant pericardial disease resulting in impaired ventricular filling and heart failure symptoms, often following cardiac surgery. Its clinical presentation complicates diagnosis, mimicking other causes of heart failure. Recent technological advances, including artificial intelligence (AI)-based non-invasive pulse wave analysis (AI-PWA), have the potential for improved haemodynamic assessment and clinical decision-making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study evaluates the clinical utility of AI-PWA in assessing central aortic blood pressure (CABP), arterial stiffness and cardiac function in CP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective case-control study enrolled 12 adult CP patients and 12 age- and sex-matched healthy controls. CABP and peripheral blood pressure (PBP) were measured using the VascAssist2. Haemodynamic parameters, including pulse wave velocity (PWV), augmentation index@75 (AIx@75), cardiac index, stroke volume and dP\/dtmax, were assessed and compared between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CP patients showed significantly lower mean CABP than systolic PBP (101.8\u00b123.4\u2009mm Hg vs 112.3\u00b122.9\u2009mm Hg). PWV showed elevated values (&gt;9 m\/s) in nnn (42%) of cases, indicating increased arterial stiffness (8.88\u00b11.94 m\/s). AIx@75 was higher in CP patients (22.55\u00b18.36%) compared with controls (16.38\u00b16.53%), reflecting increased wave reflection, increased systemic vascular resistance or enhanced aortic compliance. Cardiac performance was notably impaired in the CP group, with reduced stroke volume (64.8\u00b118.8\u2009mL vs 94.9\u00b125.0\u2009mL, p=0.003) and dP\/dtmax (724.9\u00b1228.2 mm Hg\/s vs 1055.3\u00b1203.2 mmHg\/s, p=0.0011), indicating impaired ventricular function. The heart failure index was significantly higher in CP patients (31.8\u00b118.3% vs . 6.4\u00b16.5%, p&lt;0.001), indicating substantial functional compromise.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AI-PWA provides clinically relevant insights into central haemodynamics and arterial stiffness in CP patients. This non-invasive approach may enhance diagnosis and management of CP and should be considered for integration into routine cardiologic evaluation protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/openhrt-2025-003628","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T23:35:21Z","timestamp":1767224121000},"page":"e003628","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Artificial intelligence-based assessment of central aortic haemodynamics using non-invasive pulse wave analysis in constrictive pericarditis"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9541-9888","authenticated-orcid":false,"given":"Mathieu N","family":"Suleiman","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Erlangen , Erlangen, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Dewald","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Erlangen , Erlangen, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Dreher","sequence":"additional","affiliation":[{"name":"International Center for Adults with Congenital Heart Disease, German Heart Centre Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Sophie","family":"Kaemmerer-Suleiman","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Erlangen , Erlangen, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Klawonn","sequence":"additional","affiliation":[{"name":"Biostatistics, Helmholtz Center for Infection Research, Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Middeke","sequence":"additional","affiliation":[{"name":"Hypertension Center Munich, M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Pittrow","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Erlangen , Erlangen, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Harig","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Erlangen , Erlangen, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fritz","family":"Mellert","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Erlangen , Erlangen, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"key":"2025123115351446000_12.2.e003628.1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.pcad.2016.12.008","article-title":"Constrictive Pericarditis: A Practical Clinical Approach","volume":"59","author":"Miranda","year":"2017","journal-title":"Prog Cardiovasc Dis"},{"key":"2025123115351446000_12.2.e003628.2","unstructured":"Halder J . Vergleich der nicht-invasiven bestimmung des zentralen blutdrucks mittels sphygmocor und vascassist 2. 2021."},{"key":"2025123115351446000_12.2.e003628.3","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(69)90024-4"},{"key":"2025123115351446000_12.2.e003628.4","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00405.2017"},{"key":"2025123115351446000_12.2.e003628.5","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpaa174"},{"key":"2025123115351446000_12.2.e003628.6","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-311683"},{"key":"2025123115351446000_12.2.e003628.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.07.065"},{"key":"2025123115351446000_12.2.e003628.8","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.13.1380"},{"key":"2025123115351446000_12.2.e003628.9","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13121059"},{"key":"2025123115351446000_12.2.e003628.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.09.039"},{"key":"2025123115351446000_12.2.e003628.11","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jjcc.2023.09.003","article-title":"Constrictive pericarditis in the new millennium","volume":"83","author":"Gillombardo","year":"2024","journal-title":"J Cardiol"},{"key":"2025123115351446000_12.2.e003628.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2015.04.011"},{"key":"2025123115351446000_12.2.e003628.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.11.048"},{"key":"2025123115351446000_12.2.e003628.14","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1253\/circj.CJ-16-0633","article-title":"Long-Term Clinical Outcomes and Prognostic Factors After Pericardiectomy for Constrictive Pericarditis in a Japanese Population","volume":"81","author":"Nishimura","year":"2017","journal-title":"Circ J"},{"key":"2025123115351446000_12.2.e003628.15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.001613"}],"container-title":["Open Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/openhrt-2025-003628","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T23:35:22Z","timestamp":1767224122000},"score":1,"resource":{"primary":{"URL":"https:\/\/openheart.bmj.com\/lookup\/doi\/10.1136\/openhrt-2025-003628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,12,31]]},"published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1136\/openhrt-2025-003628"],"URL":"https:\/\/doi.org\/10.1136\/openhrt-2025-003628","relation":{},"ISSN":["2053-3624"],"issn-type":[{"value":"2053-3624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}