{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:11:15Z","timestamp":1790640675969,"version":"4.1.0"},"reference-count":28,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"unspecified","delay-in-days":81,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Chongqing Natural Science Foundation","doi-asserted-by":"crossref","award":["CSTB2022NSCQ-LZX0076"],"award-info":[{"award-number":["CSTB2022NSCQ-LZX0076"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Chongqing Talent Project","award":["CQYC20220303476"],"award-info":[{"award-number":["CQYC20220303476"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2026,3,3]]},"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transcatheter aortic valve replacement (TAVR) has already been recommended for some high-risk patients with aortic valve regurgitation, but there is still a lack of evidence regarding its early-term and medium-term safety and effectiveness compared with surgical aortic valve replacement (SAVR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included patients who underwent bioprosthetic aortic valve replacement for severe aortic regurgitation (AR) at a single centre between January 2018 and December 2023. All patients in the TAVR group received the J-Valve system via transapical (TA) approach. Propensity score matching (PSM) was used to balance the groups. The primary endpoint was 2-year all-cause mortality. Secondary endpoints included other clinical events, left ventricular (LV) function recovery and prosthesis haemodynamics, assessed by transthoracic echocardiography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 369 patients (median age 68 years, 26.6% female) were enrolled. Of these, 256 underwent TA-TAVR and 113 underwent SAVR. After 1:1 PSM, 76 matched pairs were included. There were no statistical differences between the groups in all-cause mortality, cardiovascular mortality, stroke, heart failure rehospitalisation, permanent pacemaker implantation or moderate to severe paravalvular leakage at 30 days or 2 years. Before PSM, left ventricular ejection fraction (LVEF) improved in the TAVR group (57% (IQR: 45\u201363%)\u2009vs 61% (IQR: 55\u201365%), p&lt;0.001), with no significant change in the SAVR group (61% (IQR: 55\u201365%)\u2009vs 62% (IQR: 59\u201366%), p&gt;0.05). After PSM, LVEF improvement was comparable between groups (+4.0% (IQR: \u22121.5 to 10.0) vs +2.0% (IQR: \u22123.0 to 9.5), p=0.430). Haemodynamics was superior in the TAVR group (p&lt;0.001), while regression of LV dimensions was greater in the SAVR group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with severe AR, using the J-Valve for TA-TAVR showed comparable outcomes to SAVR regarding mortality and other clinical events. TAVR provided superior valve haemodynamics and was an effective treatment that significantly improved LV function, especially in high-risk patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/openhrt-2026-003969","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T16:30:17Z","timestamp":1774283417000},"page":"e003969","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Comparing TA-TAVR and SAVR in severe aortic regurgitation: outcomes and valve haemodynamics"],"prefix":"10.1136","volume":"13","author":[{"given":"Ziyan","family":"He","sequence":"first","affiliation":[{"name":"Army Medical University Xinqiao Hospital, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dekun","family":"Cai","sequence":"additional","affiliation":[{"name":"Army Medical University Xinqiao Hospital, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwen","family":"Li","sequence":"additional","affiliation":[{"name":"Army Medical University Xinqiao Hospital, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zezhou","family":"Feng","sequence":"additional","affiliation":[{"name":"Army Medical University Xinqiao Hospital, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8215-5726","authenticated-orcid":false,"given":"Chunsui","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Army Medical University Xinqiao Hospital, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyan","family":"Ma","sequence":"additional","affiliation":[{"name":"Army Medical University Xinqiao Hospital, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1757-4379","authenticated-orcid":false,"given":"Zhao","family":"Jian","sequence":"additional","affiliation":[{"name":"Army Medical University Xinqiao Hospital, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingbin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Army Medical University Xinqiao Hospital, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"2026032309300971000_13.1.e003969.1","first-page":"561","article-title":"Corrigendum to: 2021 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"62","author":"Beyersdorf","year":"2022","journal-title":"Eur Heart 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