{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:36:32Z","timestamp":1793230592230,"version":"4.5.0"},"reference-count":35,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"unspecified","delay-in-days":92,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Barbra Streisand Women\u2019s Cardiovascular Research and Education Program","award":["Cedars-Sinai Medical Center"],"award-info":[{"award-number":["Cedars-Sinai Medical Center"]}]},{"name":"Erika Glazer Women\u2019s Heart Health Project"},{"name":"VA Women\u2019s Health Practice-Based Research Network","award":["VA HSR&D SDR 10-012"],"award-info":[{"award-number":["VA HSR&D SDR 10-012"]}]},{"name":"Smidt Family Foundation"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23HL105787"],"award-info":[{"award-number":["K23HL105787"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23HL125941"],"award-info":[{"award-number":["K23HL125941"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 HL69751"],"award-info":[{"award-number":["T32 HL69751"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CDMRP-DoD","award":["W81XWH-17-2-0030"],"award-info":[{"award-number":["W81XWH-17-2-0030"]}]},{"name":"Linda Joy Pollin Women\u2019s Heart Health Program"},{"name":"Clinical Research Consortium","award":["CDRN-1501-26692"],"award-info":[{"award-number":["CDRN-1501-26692"]}]},{"name":"Edythe L. 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Secondary: components of the primary, quality of life and win ratio.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Recruitment was lower than planned (n=2476), yielding an aged population (mean, 64 years) with well-controlled blood pressure and low-density lipoprotein cholesterol at baseline, and relatively high rates of statin and ACEI\/ARB use. At 2.5 years, 421 events occurred (221 in IMT, 200 in UC) with no difference in the primary outcome (HR=1.13 (95% CI 0.94 to 1.37) for IMT vs UC, p=0.20) or secondary outcomes. Hospitalisations for angina were the dominant contributor to MACE. Sensitivity analysis of contamination provided an estimated HR for IMT versus UC of 0.74 95%\u2009CI (0.352 to 1.558), p=0.43.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Among women with suspected ANOCA\/INOCA, outcomes were dominated by chest pain and IMT did not improve outcomes, although limited power precludes concluding that it may not be helpful. The findings support the need for more investigation in this population with high burden of angina hospitalisation, health resource consumption and poor quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT03417388\">NCT03417388<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/openhrt-2026-004115","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T02:30:37Z","timestamp":1775442637000},"page":"e004115","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Women\u2019s IschemiA TRial to Reduce Events In Non-ObstRuctive CAD (WARRIOR): a randomised 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