{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:09:54Z","timestamp":1779289794528,"version":"3.51.4"},"reference-count":25,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"unspecified","delay-in-days":139,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2026,4,26]]},"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The current guideline recommends a peak tricuspid regurgitation velocity (TRV) \u22652.9 m\/s on echocardiography for pulmonary hypertension (PH) screening; however, this threshold was based on the previous PH definition (mean pulmonary arterial pressure (mPAP) \u226525\u2009mm Hg) and derived largely from PH referral centres.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analysed 755 patients who underwent both transthoracic echocardiography and right heart catheterisation at two general hospitals. The discrimination of peak TRV and estimated right atrial pressure (eRAP), derived from inferior vena cava diameter and respiratory variation, for screening for PH was assessed by receiver operating characteristic curve analysis. Optimal cut-off values were determined with the Youden Index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The c-statistic for peak TRV in detecting PH was 0.82 (95% CI 0.79 to 0.85). An optimal cut-off of 2.7 m\/s provided higher sensitivity (72%) than the conventional 2.9 m\/s threshold (60%) while maintaining high specificity (82%). In 681 patients with available TRV and eRAP data, adding eRAP improved discrimination compared with TRV alone (c-statistic 0.83 vs 0.80; net reclassification improvement=0.14, p=0.002). eRAP \u22655\u2009mm Hg was associated with a higher risk of PH, and the combination of elevated TRV and eRAP yielded the strongest association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For screening under the revised PH definition, a peak TRV of 2.7 m\/s is suggested as the optimal cut-off. Although TRV alone showed good discriminative performance, combining it with eRAP further improved diagnostic accuracy using simple echocardiographic measures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/openhrt-2026-004185","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T14:15:35Z","timestamp":1779286535000},"page":"e004185","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Predictive value of simple echocardiographic parameters for screening pulmonary hypertension under the revised definition: a study for general hospitals"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9684-2653","authenticated-orcid":false,"given":"Yoshitake","family":"Fukuda","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Akagi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Taya","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Ejiri","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Takaya","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Dohi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kure Kyosai Hospital, Kure, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Yuasa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"2026052007152572000_13.1.e004185.1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.020207"},{"key":"2026052007152572000_13.1.e004185.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.106099"},{"key":"2026052007152572000_13.1.e004185.3","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.02252"},{"key":"2026052007152572000_13.1.e004185.4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv317"},{"key":"2026052007152572000_13.1.e004185.5","doi-asserted-by":"publisher","DOI":"10.1159\/000345221"},{"key":"2026052007152572000_13.1.e004185.6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0108339","article-title":"Significance of pulmonary arterial pressure as a prognostic indicator in lung-dominant connective tissue disease","volume":"9","author":"Suzuki","year":"2014","journal-title":"PLoS 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The RIGHT Heart International NETwork (RIGHT-NET)","volume":"19","author":"Ferrara","year":"2021","journal-title":"Cardiovasc Ultrasound"},{"key":"2026052007152572000_13.1.e004185.21","article-title":"Echocardiographic evaluation of the right atrial size and function: Relevance for clinical practice","volume":"27","author":"Sun","year":"2023","journal-title":"Am Heart J Plus"},{"key":"2026052007152572000_13.1.e004185.22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7133.2010.00202.x"},{"key":"2026052007152572000_13.1.e004185.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.08.012"},{"key":"2026052007152572000_13.1.e004185.24","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1007\/s00392-023-02178-4","article-title":"Inferior vena cava diameter is associated with prognosis in patients with chronic heart failure independent of tricuspid regurgitation velocity","volume":"112","author":"Iaconelli","year":"2023","journal-title":"Clin Res Cardiol"},{"key":"2026052007152572000_13.1.e004185.25","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1016\/j.ultrasmedbio.2016.07.003","article-title":"Echocardiographic Characterization of the Inferior Vena Cava in Trained and Untrained Females","volume":"42","author":"Hedman","year":"2016","journal-title":"Ultrasound Med Biol"}],"container-title":["Open Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/openhrt-2026-004185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T14:15:37Z","timestamp":1779286537000},"score":1,"resource":{"primary":{"URL":"https:\/\/openheart.bmj.com\/lookup\/doi\/10.1136\/openhrt-2026-004185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,5,20]]},"published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1136\/openhrt-2026-004185"],"URL":"https:\/\/doi.org\/10.1136\/openhrt-2026-004185","relation":{},"ISSN":["2053-3624"],"issn-type":[{"value":"2053-3624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]}}}