{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:07:01Z","timestamp":1789556821702,"version":"build-2803163510"},"reference-count":34,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"unspecified","delay-in-days":41,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2026,7,24]]},"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The optimal revascularisation strategy for patients undergoing percutaneous coronary intervention (PCI) after transcatheter aortic valve implantation (TAVI) remains undefined. In particular, the prognostic impact of complete revascularisation (CR) versus incomplete revascularisation (ICR) in this setting is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the long-term clinical outcomes of CR versus ICR in patients undergoing PCI after TAVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed 447 patients from the multicentre, international Revascularization After Transcatheter Aortic Valve Implantation (REVIVAL) registry who underwent PCI after TAVI between 2008 and 2023. Patients were classified as CR or ICR according to the presence of residual significant stenosis following PCI. The primary endpoint was the 4-year incidence of major adverse cardiovascular events (MACE), a composite of cardiovascular death, myocardial infarction or stroke. The Kaplan-Meier method was used to estimate cumulative event rates, and a weighted Cox regression model employing an entropy balance approach was used to adjust for possible confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ICR was achieved in 132 patients (29.5%) and CR in 315 patients (70.5%). The mean follow-up after PCI was 1065\u00b1904 days (1213\u00b1938 in the ICR group; 1002\u00b1883 in the CR group). The crude 4-year incidence of MACE was 35.0% with ICR and 34.7% with CR (HR 0.93, 95% CI 0.62 to 1.39, p=0.710). Adjusted analysis confirmed no significant difference (32.5% vs 34.1%; HR 1.01, 95% CI 0.62 to 1.64, p=0.971).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this registry, CR after TAVI was common but not associated with improved outcomes compared with ICR. These results support a selective rather than systematic pursuit of CR in elderly, high-risk post-TAVI patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/openhrt-2026-004221","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T12:06:05Z","timestamp":1786449965000},"page":"e004221","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Complete versus incomplete coronary revascularisation in patients undergoing PCI after TAVI"],"prefix":"10.1136","volume":"13","clinical-trial-number":[{"clinical-trial-number":"nct03283501","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5195-8815","authenticated-orcid":false,"given":"Carlo Andrea","family":"Pivato","sequence":"first","affiliation":[{"name":"IRCCS Humanitas Research Hospital, Rozzano, Lombardy, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Lombardy, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Fontana","sequence":"additional","affiliation":[{"name":"Human Technopole, Milan, Lombardy, Italy"},{"name":"Politecnico di Milano, Dipartimento di Matematica, Milan, Lombardy, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Gramss","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital, Rozzano, Lombardy, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Lombardy, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Di Angelantonio","sequence":"additional","affiliation":[{"name":"Human Technopole, Milan, Lombardy, Italy"},{"name":"British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Ieva","sequence":"additional","affiliation":[{"name":"Human Technopole, Milan, Lombardy, Italy"},{"name":"Politecnico di Milano, Dipartimento di Matematica, Milan, Lombardy, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosmo","family":"Godino","sequence":"additional","affiliation":[{"name":"Cardio-Thoracic-Vascular Department, San Raffaele Hospital, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5359-8494","authenticated-orcid":false,"given":"Masaaki","family":"Nakase","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inselspital University Hospital, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Hug","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Technical University of Munich School of Medicine, Munich, BY, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias Andreas","family":"Rheude","sequence":"additional","affiliation":[{"name":"Department of Cardiology, German Heart Centre Munich, Munich, BY, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Jes\u00fas","family":"Mu\u00f1oz-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Virgen de la Victoria, M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Alfonso","family":"Jimenez Diaz","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Vigo University Hospital Group, Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Ielasi","sequence":"additional","affiliation":[{"name":"Cardio-Thoracic, Istituto Clinico Sant\u2019Ambrogio, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Barbanti","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Universit\u00e0 degli Studi di Enna 'Kore\u2019, Enna, Sicily, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3770-8988","authenticated-orcid":false,"given":"Giuliano","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital System Gaspare Rodolico, San Marco, Catania, Sicily, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Anzuini","sequence":"additional","affiliation":[{"name":"Mater Domini Hospital, Castellanza, Lombardy, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Quadri","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Azienda Ospedaliera Ordine Mauriziano di Torino, Turin, 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