{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:06:56Z","timestamp":1791209216520,"version":"4.1.0"},"reference-count":21,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"unspecified","delay-in-days":96,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009041","name":"National Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015777","name":"Division of Research Capacity Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015777","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2026,9,24]]},"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The relationship between pericardial inflammation and subsequent constriction in tuberculous (TB) pericarditis remains poorly understood. Late gadolinium enhancement (LGE) has shown conflicting prognostic associations, suggesting that inflammation alone may not adequately reflect disease stage or reversibility. We hypothesised that inflammatory burden and oedema provide complementary information regarding subsequent pericardial tethering, and that segments without oedema would be more likely to demonstrate tethering at follow-up than oedematous segments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants with TB pericarditis underwent baseline and 6-month cardiovascular magnetic resonance (CMR) imaging. Baseline inflammatory burden was quantified using pericardial LGE at 6 SD and 10 SD thresholds. Baseline oedema and 6-month visceral-parietal pericardial tethering were assessed segmentally using T2-weighted short tau inversion recovery imaging and radiofrequency tissue tagging, respectively, within a validated 20-segment pericardial model. Generalised estimating equation modelling was used to evaluate associations between baseline inflammatory burden, oedema and follow-up tethering.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Tethering at 6-month follow-up was present in 131\/633 oedematous segments (20.7%) compared with 138\/267 non-oedematous segments (51.7%; p&lt;0.001). Greater baseline inflammatory burden was independently associated with subsequent tethering, while baseline oedema remained independently protective. In the 6 SD model, baseline oedema was independently associated with lower odds of subsequent tethering (OR 0.29, 95%\u2009CI 0.20 to 0.43; p&lt;0.001), while greater baseline inflammatory burden was independently associated with higher odds of subsequent tethering (OR 1.32 per SD increase, 95%\u2009CI 1.12 to 1.55; p=0.0011). Similar findings were observed using 10 SD thresholds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pericardial inflammatory burden and oedema provide independent and complementary information regarding subsequent tethering in active TB pericarditis. Oedema may reflect a more acute, potentially reversible inflammatory phenotype, whereas intense inflammatory signal without oedema appears associated with a more fibrosis-prone state. These findings support multiparametric CMR for disease staging and provide longitudinal imaging evidence consistent with differing pathways of pericardial remodelling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/openhrt-2026-004489","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:30:18Z","timestamp":1791207018000},"page":"e004489","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Inflammatory burden and oedema provide complementary information on subsequent pericardial tethering in tuberculous pericarditis: a longitudinal segment-level CMR study"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8367-2969","authenticated-orcid":false,"given":"Louis Jonas","family":"Giliomee","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton F","family":"Doubell","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Innocent","family":"Maposa","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Biostatistics, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip G","family":"Herbst","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"2026100506301295000_13.2.e004489.1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv318"},{"key":"2026100506301295000_13.2.e004489.2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13121059"},{"key":"2026100506301295000_13.2.e004489.3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.026070"},{"key":"2026100506301295000_13.2.e004489.4","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2024.1329767","article-title":"Novel role of cardiovascular MRI to contextualise tuberculous pericardial inflammation and oedema as predictors of constrictive pericarditis","volume":"11","author":"Giliomee","year":"2024","journal-title":"Front Cardiovasc Med"},{"key":"2026100506301295000_13.2.e004489.5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.543066"},{"key":"2026100506301295000_13.2.e004489.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2011.08.011"},{"key":"2026100506301295000_13.2.e004489.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2013.06.023"},{"key":"2026100506301295000_13.2.e004489.8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.018580"},{"key":"2026100506301295000_13.2.e004489.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2016.10.020"},{"key":"2026100506301295000_13.2.e004489.10","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.114.003125","article-title":"Quantitative assessment of pericardial delayed hyperenhancement predicts clinical improvement in patients with constrictive pericarditis treated with anti-inflammatory therapy","volume":"8","author":"Cremer","year":"2015","journal-title":"Circ Cardiovasc Imaging"},{"key":"2026100506301295000_13.2.e004489.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2019.08.027"},{"key":"2026100506301295000_13.2.e004489.12","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcl123"},{"key":"2026100506301295000_13.2.e004489.13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.001613"},{"key":"2026100506301295000_13.2.e004489.14","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2025-003512","article-title":"Pericardial segmentation: a proposed model to quantify disease burden","volume":"12","author":"Giliomee","year":"2025","journal-title":"Open Heart"},{"key":"2026100506301295000_13.2.e004489.15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077532","article-title":"Prevalence, hemodynamics, and cytokine profile of effusive-constrictive pericarditis in patients with tuberculous pericardial effusion","volume":"8","author":"Ntsekhe","year":"2013","journal-title":"PLoS ONE"},{"key":"2026100506301295000_13.2.e004489.16","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.phrs.2018.07.006","article-title":"The anti-inflammatory peptide Ac-SDKP: Synthesis, role in ACE inhibition, and its therapeutic potential in hypertension and cardiovascular diseases","volume":"134","author":"Kumar","year":"2018","journal-title":"Pharmacol Res"},{"key":"2026100506301295000_13.2.e004489.17","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-302196"},{"key":"2026100506301295000_13.2.e004489.18","unstructured":"Giliomee LJ , Doubell AF , Herbst PG . n.d. Ventricular Distribution of Pericardial Tethering and Constrictive Haemodynamics in Tuberculous Pericarditis. In Press. SA Heart."},{"key":"2026100506301295000_13.2.e004489.19","doi-asserted-by":"publisher","DOI":"10.4250\/jcu.2016.24.4.317"},{"key":"2026100506301295000_13.2.e004489.20","unstructured":"Kyriakakis C , Herbst PG , Doubell AF . Constrictive pericarditis: prevalence, causes and clinical presentation. ESC E-Journal of Cardiology Practice 2017;15."},{"key":"2026100506301295000_13.2.e004489.21","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.jtcvs.2015.12.035","article-title":"Cardiac magnetic resonance radiofrequency tissue tagging for diagnosis of constrictive pericarditis: A proof of concept study","volume":"151","author":"Power","year":"2016","journal-title":"J Thorac Cardiovasc Surg"}],"container-title":["Open Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/openhrt-2026-004489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:30:21Z","timestamp":1791207021000},"score":1,"resource":{"primary":{"URL":"https:\/\/openheart.bmj.com\/lookup\/doi\/10.1136\/openhrt-2026-004489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,10,5]]},"published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1136\/openhrt-2026-004489"],"URL":"https:\/\/doi.org\/10.1136\/openhrt-2026-004489","relation":{},"ISSN":["2053-3624"],"issn-type":[{"value":"2053-3624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]}}}