{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T13:34:00Z","timestamp":1770298440351,"version":"3.49.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"949","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,11,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Introduction: Recent studies of patients with colorectal cancer have suggested a shift towards the proximal colon and an increase in the incidence of right sided colon cancer. This study aimed to determine the anatomical distribution of colorectal cancer over a 10 year period in a district general hospital.<\/jats:p>\n               <jats:p>Methods: Records of patients diagnosed with primary colorectal cancer from 1993 to 2002 were reviewed for demographic data, histology subtype, and anatomical location of the tumour. Tumours located at and proximal to the splenic flexure were defined as right sided cancer and tumours arising distal to the splenic flexure were defined as left sided cancer.<\/jats:p>\n               <jats:p>Results: A total of 763 patients were included in the study, of whom all had adenocarcinoma and 99% were white. Sixty nine percent of cancers were left sided and 31% were right sided. Although there was a 4% increase in the proportion of right sided cancers, there was no statistically significant increase using logistic regression analysis. Mann-Whitney U test revealed no significant difference in age at diagnosis between the right and left sided cancers. Although a higher proportion of females were diagnosed with right sided cancer compared with left sided cancer, this was not statistically significant.<\/jats:p>\n               <jats:p>Conclusion: The anatomical distribution of colorectal cancer has been fairly stable at this hospital with no evidence of a shift towards the proximal colon. No differences were identified in the tumour distribution with respect to gender and age at diagnosis. Our findings support the initial application of flexible sigmoidoscopy for investigating patients with suspected colorectal malignancy and follow up colonoscopy for selected patients to exclude right sided pathology.<\/jats:p>","DOI":"10.1136\/pgmj.2004.020198","type":"journal-article","created":{"date-parts":[[2004,11,10]],"date-time":"2004-11-10T20:54:01Z","timestamp":1100120041000},"page":"667-669","source":"Crossref","is-referenced-by-count":43,"title":["Anatomical distribution of colorectal cancer over a 10 year period in a district general hospital: is there a true \u201crightward shift\u201d?"],"prefix":"10.1093","volume":"80","author":[{"given":"D","family":"Gomez","sequence":"first","affiliation":[{"name":"Department of Surgery, Dewsbury Health Care NHS Trust , Dewsbury, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Dalal","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dewsbury Health Care NHS Trust , Dewsbury, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Raw","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dewsbury Health Care NHS Trust , Dewsbury, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dewsbury Health Care NHS Trust , Dewsbury, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Lyndon","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dewsbury Health Care NHS Trust , Dewsbury, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2004,11,10]]},"reference":[{"key":"2023050810583780400_R1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0748-7983(98)93464-3","article-title":"The incidence and Dukes\u2019 staging of colorectal cancer over 3 decades","volume":"24","author":"Wakefield","year":"1998","journal-title":"Eur J Surg Oncol"},{"key":"2023050810583780400_R2","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/1097-0142(196606)19:6<750::AID-CNCR2820190603>3.0.CO;2-B","article-title":"Changing relative frequency of cancers of the colon and rectum in United States","volume":"19","author":"Axtell","year":"1966","journal-title":"Cancer"},{"key":"2023050810583780400_R3","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/0002-9610(79)90124-7","article-title":"Increasing incidence of right sided lesions in colorectal cancer","volume":"137","author":"Abrams","year":"1979","journal-title":"Am J Surg"},{"key":"2023050810583780400_R4","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1097\/00004836-198612000-00008","article-title":"Rightward shift of colon cancer. 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