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Terlipressin or somatostatin combined with endoscopic ligation or sclerotherapy is the best strategy for control of bleeding but there is no added effect of vasoactive drugs on mortality. Non-selective \u03b2-blockers are the first choice therapy for both secondary and primary prevention; if contraindications or intolerance to \u03b2-blockers are present then band ligation should be used. Novel therapies target the increased intrahepatic resistance caused by microcirculatory intrahepatic deficiency of nitric oxide and contraction of activated intrahepatic stellate cells.<\/jats:p>","DOI":"10.1136\/pgmj.2004.020446","type":"journal-article","created":{"date-parts":[[2004,11,10]],"date-time":"2004-11-10T20:54:01Z","timestamp":1100120041000},"page":"634-641","source":"Crossref","is-referenced-by-count":21,"title":["Management of portal hypertension"],"prefix":"10.1093","volume":"80","author":[{"given":"D N","family":"Samonakis","sequence":"first","affiliation":[{"name":"Liver Transplant and Hepatobiliary Medicine Unit, Royal Free Hospital , London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C K","family":"Triantos","sequence":"additional","affiliation":[{"name":"Liver Transplant and Hepatobiliary Medicine Unit, Royal Free Hospital , London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U","family":"Thalheimer","sequence":"additional","affiliation":[{"name":"Liver Transplant and Hepatobiliary Medicine Unit, Royal Free Hospital , London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D W","family":"Patch","sequence":"additional","affiliation":[{"name":"Liver Transplant and Hepatobiliary Medicine Unit, Royal Free Hospital , London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A K","family":"Burroughs","sequence":"additional","affiliation":[{"name":"Liver Transplant and Hepatobiliary Medicine Unit, Royal Free Hospital , London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2004,11,10]]},"reference":[{"key":"2023050810583553500_R1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/hep.1840050313","article-title":"Portal pressure, presence of gastroesophageal varices and variceal bleeding","volume":"5","author":"Garcia-Tsao","year":"1985","journal-title":"Hepatology"},{"key":"2023050810583553500_R2","first-page":"332","article-title":"The treatment of portal hypertension: a meta-analytic review","volume":"22","author":"D\u2019Amico","year":"1995","journal-title":"Hepatology"},{"key":"2023050810583553500_R3","first-page":"1081","article-title":"Diagnosis and treatment of gastrointestinal bleeding secondary to portal hypertension. 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