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Although methadone is most widely known for its use in the treatment of opioid dependence, methadone also provides effective analgesia. Patients who experience inadequate pain relief or intolerable side effects with other opioids or who suffer from neuropathic pain may benefit from a transition to methadone as their analgesic agent. Adverse effects, particularly respiratory depression and death, make a fundamental knowledge of methadone\u2019s pharmacological properties essential to the provider considering methadone as analgesic therapy for a patient with chronic pain.<\/jats:p>","DOI":"10.1136\/pgmj.2004.022988","type":"journal-article","created":{"date-parts":[[2004,11,10]],"date-time":"2004-11-10T20:54:01Z","timestamp":1100120041000},"page":"654-659","source":"Crossref","is-referenced-by-count":94,"title":["Methadone: applied pharmacology and use as adjunctive treatment in chronic pain"],"prefix":"10.1093","volume":"80","author":[{"given":"R","family":"Brown","sequence":"first","affiliation":[{"name":"University of Wisconsin Department of Family Medicine and Department of Population Health Sciences, and Madison Health Services Methadone Treatment Facility , Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Kraus","sequence":"additional","affiliation":[{"name":"University of Wisconsin Department of Pharmacy , Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Fleming","sequence":"additional","affiliation":[{"name":"University of Wisconsin Department of Family Medicine , Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Reddy","sequence":"additional","affiliation":[{"name":"University of Wisconsin Medical School , Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,11,10]]},"reference":[{"key":"2023050810584920400_R1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1191\/096813098673619329","article-title":"The use of methadone in cancer pain poorly responsive to other opiates","volume":"5","author":"Morley","year":"1998","journal-title":"Pain Reviews"},{"key":"2023050810584920400_R2","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/(SICI)1097-0142(19960815)78:4<852::AID-CNCR23>3.0.CO;2-T","article-title":"Opioid rotation in patients with cancer pain. 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