{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:50:09Z","timestamp":1780447809990,"version":"3.54.1"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"958","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To determine the prevalence of acanthosis nigricans (AN) in type 2 diabetes mellitus (T2DM) and its correlation with various anthropometric measurements in Indians.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>One hundred and fifty consecutive subjects with T2DM attending the diabetes clinic at a tertiary referral centre in North India were considered as cases and 150 age and sex matched healthy attendants of non-diabetic subjects as controls. All the cases and controls were screened for the presence of AN and its severity. Anthropometric measurements of all of them were measured in standard method. Regression analysis was done to determine the association of AN with T2DM and various anthropometric measurements.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The prevalence of AN in subjects with diabetes and healthy controls was 62.6% and 40% respectively, and this difference was significant (p&amp;lt;0.05). Body mass index (BMI) between cases and controls was comparable by chance. There was a statistically significant correlation of increasing severity of AN with increasing BMI, waist circumference, hip circumference, waist-hip ratio, skinfold thickness, and body fat percentage in diabetic patients. However, in regression analysis after considering all the confounding factors there was a significant correlation of AN, only with diabetes mellitus and BMI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Indians have high prevalence of AN and it is an independent cutaneous marker of both T2DM and BMI.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/pgmj.2004.028308","type":"journal-article","created":{"date-parts":[[2005,8,5]],"date-time":"2005-08-05T16:42:51Z","timestamp":1123260171000},"page":"541-544","source":"Crossref","is-referenced-by-count":19,"title":["Acanthosis nigricans: relation with type 2 diabetes mellitus, anthropometric variables, and body mass in Indians"],"prefix":"10.1093","volume":"81","author":[{"given":"N P","family":"Grandhe","sequence":"first","affiliation":[{"name":"Department of Dermatology, Postgraduate Institute of Medical Education and Research , Chandigarh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Bhansali","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Postgraduate Institute of Medical Education and Research , Chandigarh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Dogra","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Postgraduate Institute of Medical Education and Research , Chandigarh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Postgraduate Institute of Medical Education and Research , Chandigarh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,8,5]]},"reference":[{"key":"2023042408394784300_R1","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.2337\/diacare.21.9.1414","article-title":"Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections.","volume":"21","author":"King","year":"1998","journal-title":"Diabetes Care"},{"key":"2023042408394784300_R2","volume-title":"Diabetes Atlas","author":"International Diabetes Federation","year":"2000"},{"key":"2023042408394784300_R3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/00006205-199202000-00013","article-title":"Assessment of patients with acanthosis nigricans skin lesion for hyperinsulinemia, insulin resistance and diabetes risk.","volume":"17","author":"Gilkison","year":"1992","journal-title":"Nurse Pract"},{"key":"2023042408394784300_R4","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0002-9343(89)80149-4","article-title":"Prevalence of acanthosis nigricans in an unselected population.","volume":"87","author":"Stuart","year":"1989","journal-title":"Am J Med"},{"key":"2023042408394784300_R5","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1001\/archderm.1992.01680170073009","article-title":"Prevalence and significance of acanthosis nigricans in an adult obese population.","volume":"128","author":"Hud JA Jr, Cohen","year":"1992","journal-title":"Arch Dermatol"},{"key":"2023042408394784300_R6","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.2337\/diacare.22.10.1655","article-title":"A quantitative scale of acanthosis nigricans.","volume":"22","author":"Burke","year":"1999","journal-title":"Diabetes Care"},{"key":"2023042408394784300_R7","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.2337\/diacare.26.2007.S5","article-title":"Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus","volume":"26","author":"The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus","year":"2003","journal-title":"Diabetes Care"},{"key":"2023042408394784300_R8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000246834","article-title":"Acanthosis nigricans caused by nicotinic acid: case report and review of the literature.","volume":"189","author":"Stals","year":"1994","journal-title":"Dermatology"},{"key":"2023042408394784300_R9","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1365-2133.1992.tb00692.x","article-title":"Resolution of nicotinic acid-induced acanthosis nigricans by substitution of an analogue (acipimox) in a patient with type V hyperlipidaemia.","volume":"126","author":"Coates","year":"1992","journal-title":"Br J Dermatol"},{"key":"2023042408394784300_R10","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0190-9622(08)81767-7","article-title":"Acanthosis nigricans-like lesions after local application of fusidic acid.","volume":"28","author":"Teknetzis","year":"1993","journal-title":"J Am Acad Dermatol"},{"key":"2023042408394784300_R11","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1001\/archderm.1964.01590260060010","article-title":"Acanthosis nigricans-like lesions from nicotinic acid.","volume":"89","author":"Tromovitch","year":"1964","journal-title":"Arch Dermatol"},{"key":"2023042408394784300_R12","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1001\/archderm.1975.01630200129018","article-title":"Acanthosis nigricans following use of oral contraceptives.","volume":"111","author":"Curth","year":"1975","journal-title":"Arch Dermatol"},{"key":"2023042408394784300_R13","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.2337\/diacare.26.5.1380","article-title":"Cut-off values for normal anthropometric variables in asian Indian adults.","volume":"26","author":"Snehalatha","year":"2003","journal-title":"Diabetes Care"},{"key":"2023042408394784300_R14","first-page":"223","article-title":"Body composition from fluid spaces and density: analysis of methods. In: Brozek J, Henschel A, eds.","author":"Siri","year":"1961","journal-title":"Techniques for measuring body composition"},{"key":"2023042408394784300_R15","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.2105\/AJPH.84.11.1839","article-title":"Acanthosis nigricans among Native Americans: an indicator of high diabetes risk.","volume":"84","author":"Stuart","year":"1994","journal-title":"Am J Public Health"},{"key":"2023042408394784300_R16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1177\/000992289803700203","article-title":"Acanthosis nigricans as a risk factor for non-insulin dependent diabetes mellitus.","volume":"37","author":"Stuart","year":"1998","journal-title":"Clin Pediatr (Phila)"},{"key":"2023042408394784300_R17","first-page":"137","article-title":"Body composition, visceral fat, leptin, and insulin resistance in Asian Indian men.","volume":"84","author":"Banerji","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2023042408394784300_R18","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.2337\/diacare.25.12.2353","article-title":"Is acanthosis nigricans a marker of insulin resistance in obese children?","volume":"25","author":"Hirschler","year":"2002","journal-title":"Diabetes Care"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/81\/958\/541\/50025606\/postgradmedj-81-541.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/81\/958\/541\/50025606\/postgradmedj-81-541.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T08:42:59Z","timestamp":1682325779000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/81\/958\/541\/7032207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,1]]},"references-count":18,"journal-issue":{"issue":"958","published-online":{"date-parts":[[2005,8,5]]},"published-print":{"date-parts":[[2005,8,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.2004.028308","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2005,8]]},"published":{"date-parts":[[2005,8,1]]}}}