{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T23:44:41Z","timestamp":1768779881848,"version":"3.49.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"961","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate the right and left ventricular systolic and diastolic function in middle aged patients with sickle \u03b2 thalassaemia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Forty three patients with sickle \u03b2 thalassaemia were recruited for echocardiographic study while 55 controls, matched for age and sex, served as the control group. Parameters measured included: dimensions and wall thickness of left (LV) and right (RV) ventricle and left atrium, LV mass, and cardiac index. LV and RV contractility variables\u2014ejection fraction, circumferential fibre shortening velocity, end systolic stress, end systolic stress\/volume index ratio, mitral and tricuspid annulus systolic excursion, and Tei index\u2014were also calculated. The study also evaluated parameters of RV and LV diastolic function including early and late atrioventricular flow velocities (E and A wave respectively), E\/A ratio, deceleration time (DT), isovolumic relaxation time (IVRT) as well as pulmonary and hepatic veins systolic to diastolic (S\/D) ratio.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Chamber enlargement, greater LV mass index, cardiac index, and RV wall thickness were found in the anaemic group compared with controls. The LV and RV contractility variables of the patients were similar to controls. Conversely the LV and RV Tei index was significantly greater in the patient group. Diastolic dysfunction was present in the anaemic patients resulting from the increased LV and RV A-wave, the longer LVIVRT, RVIVRT, and RVDT, as well as the higher hepatic and pulmonary veins S\/D ratio.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The results show that in middle aged patients with sickle \u03b2 thalassaemia the diastolic function is abnormal in both ventricles but still more in RV, whereas the systolic function remains unchanged.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/pgmj.2004.031096","type":"journal-article","created":{"date-parts":[[2005,11,4]],"date-time":"2005-11-04T17:28:23Z","timestamp":1131125303000},"page":"711-714","source":"Crossref","is-referenced-by-count":5,"title":["Systolic and diastolic function in middle aged patients with sickle \u03b2 thalassaemia. An echocardiographic study"],"prefix":"10.1093","volume":"81","author":[{"given":"I","family":"Moyssakis","sequence":"first","affiliation":[{"name":"Cardiology Department, Laiko General Hospital , Athens , Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Tzanetea","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, University of Athens Medical School, Laiko General Hospital , Athens , Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Tsaftaridis","sequence":"additional","affiliation":[{"name":"Thalassemia Department, Laiko General Hospital , Athens , Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Rombos","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, University of Athens Medical School, Laiko General Hospital , Athens , Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D P","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Cardiology Department, Laiko General Hospital , Athens , Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Kalotychou","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, University of Athens Medical School, Laiko General Hospital , Athens , Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Aessopos","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, University of Athens Medical School, Laiko General Hospital , Athens , Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,11,4]]},"reference":[{"key":"2023042409053018500_R1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0031-3955(05)70426-0","article-title":"Sickle cell disease.","volume":"43","author":"Lane","year":"1996","journal-title":"Pediatr Clin North Am"},{"key":"2023042409053018500_R2","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1001\/archinte.1982.00340220096017","article-title":"The heart in sickle cell anemia.","volume":"142","author":"Falk","year":"1982","journal-title":"Arch Intern Med"},{"key":"2023042409053018500_R3","first-page":"271","article-title":"Two-dimensional real time ultrasonic imaging of the heart and great vessels: technique, image orientation, structure identification and validation.","volume":"53","author":"Tajik","year":"1978","journal-title":"Mayo Clin Proc"},{"key":"2023042409053018500_R4","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/0002-9149(86)90771-X","article-title":"Echocardiographic assessment of the left ventricular hypertrophy. Comparison to necropsy findings.","volume":"57","author":"Devereux","year":"1986","journal-title":"Am J Cardiol"},{"key":"2023042409053018500_R5","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1161\/01.CIR.70.3.425","article-title":"Pulsed Doppler echocardiographic determination of stroke volume and cardiac output: clinical validation of two new methods using the apical window.","volume":"70","author":"Lewis","year":"1984","journal-title":"Circulation"},{"key":"2023042409053018500_R6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0735-1097(83)80379-9","article-title":"Estimation of circumferential fiber shortening velocity by echocardiography.","volume":"2","author":"Ruschhaupt","year":"1983","journal-title":"J Am Coll Cardiol"},{"key":"2023042409053018500_R7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1161\/01.CIR.65.1.99","article-title":"Noninvasive determination of end-systolic stress: validation of the method and initial 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