{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:08:21Z","timestamp":1765886901042},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"965","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To examine the 21 month clinical outcome and bleeding complications in hospital survivors with non-ST segment elevation acute coronary syndromes (NSTEACS) who were discharged with combined clopidogrel and aspirin anti-thrombotic therapy, and compare with those having ST segment elevation myocardial infarction (STEMI) who were discharged with aspirin alone.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Observational study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>A large university hospital.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients<\/jats:title>\n                  <jats:p>224 patients were admitted to hospital with either NSTEACS or STEMI, and survived to discharge between 1 October 2001 and 31 December 2002.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>Cardiovascular death, total death, new myocardial infarction, unstable angina requiring hospitalisation, stroke or transient ischaemic attack, coronary revascularisation; and fatal, life threatening, major and minor bleeding over 21 months after discharge.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Despite having no or small infarct (median maximum creatine kinase 155 v 1295 u\/l; p&amp;lt;0.001) and taking more antianginal drugs, patients with NSTEACS had similar rates of cardiovascular death (9.5% v 8.3%; p\u200a=\u200aNS), new myocardial infarction (9.5% v 6.5%; p\u200a=\u200aNS) or unstable angina requiring hospitalisation (15.5% v 10.2%; p\u200a=\u200aNS) when compared with STEMI. Fatal, life threatening or major bleeding were &amp;lt;1% in both groups (p\u200a=\u200aNS); and minor bleeding occurred in 4.3% NSTEACS and 2.8% STEMI patients respectively (p\u200a=\u200aNS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Patients with NSTEACS had a similar and unfavourable long term outcome when compared with STEMI. There was no difference in serious bleeding complications between both groups.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/pgmj.2005.040097","type":"journal-article","created":{"date-parts":[[2006,3,3]],"date-time":"2006-03-03T21:42:58Z","timestamp":1141422178000},"page":"224-227","source":"Crossref","is-referenced-by-count":2,"title":["Long term clinical outcome and bleeding complications among hospital survivors with acute coronary syndromes"],"prefix":"10.1093","volume":"82","author":[{"given":"P","family":"Wong","sequence":"first","affiliation":[{"name":"Aintree Cardiac Centre, University Hospital Aintree , Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Robinson","sequence":"additional","affiliation":[{"name":"Aintree Cardiac Centre, University Hospital Aintree , Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Shaw","sequence":"additional","affiliation":[{"name":"Aintree Cardiac Centre, University Hospital Aintree , Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Aintree Cardiac Centre, University Hospital Aintree , Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,3,3]]},"reference":[{"key":"2023042013503729800_bib1","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0735-1097(00)00804-4","article-title":"Myocardial infarction redefined\u2014a consensus document of The Joint European Society of Cardiology\/American College of Cardiology Committee for the redefinition of myocardial infarction","volume":"36","author":"Alpert","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"2023042013503729800_bib2","first-page":"133","article-title":"British Cardiac Society Guidelines and Medical Practice Committee, Royal College of Physicians Clinical Effectiveness and Evaluation Unit","volume":"85","author":"Anon","year":"2001","journal-title":"Heart"},{"key":"2023042013503729800_bib3","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1053\/euhj.2002.3385","article-title":"Management of acute coronary syndromes in patients without persistent ST-segment elevation. 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