{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T15:46:01Z","timestamp":1745595961053},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"968","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Severe gastrointestinal tract involvement is a rare manifestation of Stevens-Johnson syndrome (SJS). The case is described of a 17 year old man who developed SJS secondary to phenytoin. In addition to the cutaneous, ocular, and oral mucosal lesions typical of SJS, he also developed persistent, bloody diarrhoea associated with life threatening malnutrition. Serial colonoscopy showed severe and progressive colitis. He was treated with a combination of long term nutritional support, probiotic therapy, and supportive measures. He was eventually discharged from hospital six months after admission when the diarrhoea improved and he began to gain weight.<\/jats:p>","DOI":"10.1136\/pgmj.2005.042952","type":"journal-article","created":{"date-parts":[[2006,6,5]],"date-time":"2006-06-05T16:31:38Z","timestamp":1149525098000},"page":"e10-e10","source":"Crossref","is-referenced-by-count":21,"title":["Colonic involvement in Stevens-Johnson syndrome"],"prefix":"10.1093","volume":"82","author":[{"given":"N","family":"Powell","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Queen Elizabeth Hospital , London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Munro","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Queen Elizabeth Hospital , London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Rowbotham","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Queen Elizabeth Hospital , London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,6,5]]},"reference":[{"key":"2023042014054421900_bib1","first-page":"870","volume-title":"Oxford textbook of medicine","author":"Warrell","year":"2003"},{"key":"2023042014054421900_bib2","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1001\/archderm.138.8.1019","article-title":"Correlations between clinical patterns and causes of erythema multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis: results of an international prospective study","volume":"138","author":"Auquier-Dunant","year":"2002","journal-title":"Arch Dermatol"},{"key":"2023042014054421900_bib3","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1055\/s-2001-15091","article-title":"Esophageal involvement in Stevens-Johnson syndrome","volume":"33","author":"Lamireau","year":"2001","journal-title":"Endoscopy"},{"key":"2023042014054421900_bib4","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1016\/0016-5085(85)90025-3","article-title":"Bullous esophageal lesions due to cotrimoxazole: an immune-mediated process?","volume":"88","author":"Heer","year":"1985","journal-title":"Gastroenterology"},{"key":"2023042014054421900_bib5","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0016-5085(86)90585-8","article-title":"Gastrointestinal involvement complicating Stevens-Johnson syndrome","volume":"91","author":"Zweiban","year":"1986","journal-title":"Gastroenterology"},{"key":"2023042014054421900_bib6","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1023\/A:1012351231143","article-title":"Stevens-Johnson syndrome and cholestatic hepatitis","volume":"46","author":"Morelli","year":"2001","journal-title":"Dig Dis Sci"},{"key":"2023042014054421900_bib7","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0016-5085(98)70154-4","article-title":"Drug-associated acute-onset vanishing bile duct and Stevens-Johnson syndromes in a child","volume":"115","author":"Srivastava","year":"1998","journal-title":"Gastroenterology"},{"key":"2023042014054421900_bib8","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1365-2230.1979.tb01618.x","article-title":"Severe erythema multiforme complicated by fatal gastrointestinal involvement following co-trimoxazole therapy","volume":"4","author":"Beck","year":"1979","journal-title":"Clin Exp Dermatol"},{"key":"2023042014054421900_bib9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2500\/108854100778250914","article-title":"Corticosteroid therapy in an additional 13 cases of Stevens-Johnson syndrome: a total series of 67 cases","volume":"21","author":"Tripathi","year":"2000","journal-title":"Allergy Asthma Proc"},{"key":"2023042014054421900_bib10","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1542\/peds.112.6.1430","article-title":"Use of intravenous immunoglobulin in children with Stevens-Johnson syndrome and toxic epidermal necrolysis: seven cases and review of the literature","volume":"112","author":"Metry","year":"2003","journal-title":"Pediatrics"},{"key":"2023042014054421900_bib11","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1126\/science.282.5388.490","article-title":"Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin","volume":"282","author":"Viard","year":"1998","journal-title":"Science"},{"key":"2023042014054421900_bib12","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1136\/gut.2004.044834","article-title":"Synbiotic therapy (Bifidobacterium longum\/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trial","volume":"54","author":"Furrie","year":"2005","journal-title":"Gut"},{"key":"2023042014054421900_bib13","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/00130832-200108000-00003","article-title":"Physiopathology and treatment of severe drug reactions","volume":"1","author":"Bachot","year":"2001","journal-title":"Current Opinion in Allergy and Clinical Immunology"},{"key":"2023042014054421900_bib14","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/ijc.2910570314","article-title":"Expression of APO-1 (CD95), a member of the NGF\/TNF receptor superfamily, in normal and neoplastic colon epithelium","volume":"57","author":"Moller","year":"1994","journal-title":"Int J Cancer"},{"key":"2023042014054421900_bib15","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.0105-2896.2005.00218.x","article-title":"Tumour necrosis factor family members and inflammatory bowel disease","volume":"204","author":"Wang","year":"2005","journal-title":"Immunol Rev"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/82\/968\/e10\/50024892\/postgradmedj-82-e10.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/82\/968\/e10\/50024892\/postgradmedj-82-e10.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T17:11:42Z","timestamp":1682010702000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/82\/968\/e10\/7045344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,1]]},"references-count":15,"journal-issue":{"issue":"968","published-online":{"date-parts":[[2006,6,5]]},"published-print":{"date-parts":[[2006,6,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.2005.042952","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2006,6]]},"published":{"date-parts":[[2006,6,1]]}}}