{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:40:28Z","timestamp":1792683628485,"version":"4.5.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"969","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,7,1]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n The aim of this prospective study was to evaluate the proportion of children with delayed recognition of congenital heart disease (CHD).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Of the 744 children with CHD primarily diagnosed during a 10 year period in one hospital, the patients were identified where the diagnosis of CHD was established with a significant delay.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Sixty six patients (8.9%) had delayed diagnosis of CHD. Among patients with cyanotic CHD, 10.4% (7 of 67 cases) were referred after they had initially been discharged home from the birth clinic. Among patients with acyanotic CHD, 8.7% (59 of 677) of all children and 35.1% (59 of 168) of the children who required surgery or interventional catheterisation were referred at an age where elective repair should have already been performed or needed immediate treatment because of their haemodynamic status. Of the 66 patients with delayed diagnosis, one infant with cor triatriatum died at admission because of delayed referral and 10 children had severe complications: preoperative cardiogenic shock in seven cases of aortic coarctation and one case of endocardial fibroelastosis, pulmonary hypertensive crisis in one child after delayed repair of a ventricular septal defect, and infectious endocarditis after dental care in a teenager with undiagnosed moderate aortic stenosis, who required Ross operation a few months later.<\/jats:p>\n <\/jats:sec>\n \n Discussion and conclusion<\/jats:title>\n A substantial proportion of CHD was detected with relevant delay. In all cases of late diagnosis, clinical cardiac findings were present that should have alerted the physician on the possible presence of underlying CHD.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/pgmj.2005.044495","type":"journal-article","created":{"date-parts":[[2006,7,6]],"date-time":"2006-07-06T02:13:27Z","timestamp":1152152007000},"page":"468-470","source":"Crossref","is-referenced-by-count":48,"title":["Delayed recognition of congenital heart disease"],"prefix":"10.1093","volume":"82","author":[{"given":"M M","family":"Massin","sequence":"first","affiliation":[{"name":"Division of Paediatric Cardiology, Queen Fabiola Children's University Hospital, Free University of Brussels , Belgium"},{"name":"Division of Paediatric Cardiology, University of Li\u00e8ge at CHR Citadelle , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Dessy","sequence":"additional","affiliation":[{"name":"Division of Paediatric Cardiology, Queen Fabiola Children's University Hospital, Free University of Brussels , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,7,5]]},"reference":[{"key":"2023042014054843700_bib1","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0002-9149(78)90635-5","article-title":"Congenital heart disease in a cohort of 19502 births with long-term follow-up","volume":"42","author":"Hoffman","year":"1978","journal-title":"Am J Cardiol"},{"key":"2023042014054843700_bib2","first-page":"31","article-title":"Echokardiographisch neu entdeckte kongenitale Vitien und Anomalien bei Adoleszenten und Erwachsenen","volume":"120","author":"Eichhorn","year":"1990","journal-title":"Schweiz Med Wochenschr"},{"key":"2023042014054843700_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/adc.71.1.3","article-title":"Death in infancy from unrecognised congenital heart disease","volume":"71","author":"Abu-Harb","year":"1994","journal-title":"Arch Dis Child"},{"key":"2023042014054843700_bib4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s004319900437","article-title":"Delayed recognition of haemodynamically relevant congenital heart disease","volume":"160","author":"Pfammatter","year":"2001","journal-title":"Eur J Pediatr"},{"key":"2023042014054843700_bib5","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/j.1651-2227.1997.tb08580.x","article-title":"Clinical and echocardiographic evaluation of neonates with heart murmurs","volume":"86","author":"Du","year":"1997","journal-title":"Acta Paediatr"},{"key":"2023042014054843700_bib6","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1017\/S1047951100008398","article-title":"Early clinical screening of neonates for congenital heart defects: the cases we miss","volume":"9","author":"Meberg","year":"1999","journal-title":"Cardiol Young"},{"key":"2023042014054843700_bib7","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1056\/NEJM199012133232401","article-title":"Long-term outcome after surgical repair of isolated atrial septal defect","volume":"323","author":"Murphy","year":"1990","journal-title":"N Engl J Med"},{"key":"2023042014054843700_bib8","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0022-5223(94)70264-0","article-title":"Influence of age on survival, late hypertension and recoarctation in elective aortic coarctation repair","volume":"108","author":"Brouwer","year":"1994","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2023042014054843700_bib9","first-page":"770","article-title":"Early diagnosis of coarctation of the aorta in children: a challenge","volume":"55","author":"Maeyns","year":"2000","journal-title":"Rev Med Liege"},{"key":"2023042014054843700_bib10","doi-asserted-by":"crossref","first-page":"F71","DOI":"10.1136\/fn.70.1.F71","article-title":"Assessment and management of congenital heart in the newborn by the district paediatrician","volume":"70","author":"","year":"1994","journal-title":"Arch Dis Child"},{"key":"2023042014054843700_bib11","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1542\/peds.103.4.743","article-title":"Failure to diagnose congenital heart disease in infancy","volume":"103","author":"Kuehl","year":"1999","journal-title":"Pediatrics"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/82\/969\/468\/50024320\/postgradmedj-82-468.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/82\/969\/468\/50024320\/postgradmedj-82-468.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T13:13:12Z","timestamp":1681996392000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/82\/969\/468\/7045112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,1]]},"references-count":11,"journal-issue":{"issue":"969","published-online":{"date-parts":[[2006,7,5]]},"published-print":{"date-parts":[[2006,7,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.2005.044495","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2006,7]]},"published":{"date-parts":[[2006,7,1]]}}}