{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:35:17Z","timestamp":1774434917943,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"971","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Extrinsic allergic alveolitis (EAA) is an immunologically mediated interstitial lung disease. The abnormalities in the bronchoalveolar lavage (BAL) fluid cell counts are almost always seen in patients with EAA according to the stage of the disease. The aim of this retrospective study was to find out how the BAL lymphocyte count, percentage of lymphocytes expressing HLA-DR, CD4\/CD8 T cell ratio in BAL fluid, and the concentration of immunoglobulin G in serum correspond to the inflammatory activity of the disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The study included 14 patients with EAA. BAL fluid samples were obtained and processed for cytological and cytometric analysis. Immunoglobulin G serum concentrations were measured. High resolution computed tomography (HRCT) scoring system modified by Gay was used for establishing the alveolar and interstitial score in each patient.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>It was found that subjects with normal value of CD4\/CD8 ratio in BAL fluid had higher interstitial HRCT score. Clinical presentation, continuous exposure to the causative antigens, and BAL lymphocyte count positively correlated with the alveolar HRCT score. It is proposed that the increased BAL lymphocyte count could be the predictor of the inflammatory activity of the disease, especially in people with lasting exposure to the offending antigen.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/pgmj.2005.044735","type":"journal-article","created":{"date-parts":[[2006,9,5]],"date-time":"2006-09-05T19:17:50Z","timestamp":1157483870000},"page":"598-601","source":"Crossref","is-referenced-by-count":12,"title":["Extrinsic allergic alveolitis: comparative study of the bronchoalveolar lavage profiles and radiological presentation"],"prefix":"10.1093","volume":"82","author":[{"given":"M","family":"Sterclova","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Thomayer's Faculty Hospital , Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Vasakova","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Thomayer's Faculty Hospital , Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Dutka","sequence":"additional","affiliation":[{"name":"Department of Radiology, Thomayer's Faculty Hospital , Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Kalanin","sequence":"additional","affiliation":[{"name":"Department of Immunology, Institute for Clinical and Experimental Medicine , Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,9,5]]},"reference":[{"key":"2023042408014418000_bib1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/eji.200324634","article-title":"Chemokine production during hypersensitivity pneumonitis","volume":"34","author":"Nance","year":"2004","journal-title":"Eur J Immunol"},{"key":"2023042408014418000_bib2","first-page":"878","article-title":"CD4\/CD8 lymphocytes in BALF during the efferent phase of lung delayed-type hypersensitivity reaction induced by single antigen inhalation","volume":"7","author":"Grubek-Jaworska","year":"2001","journal-title":"Med Sci Monit"},{"key":"2023042408014418000_bib3","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1164\/ajrccm\/146.6.1582","article-title":"CD3+ and CD4+ Cells adoptively transfer experimental hypersensitivity pneumonitis","volume":"146","author":"Schuyler","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"2023042408014418000_bib4","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1164\/rccm.200301-137OC","article-title":"Clinical diagnosis of hypersensitivity pneumonitis","volume":"168","author":"Lacasse","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"2023042408014418000_bib5","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1055\/s-2003-42376","article-title":"The HRCT feautures of extrinsic allergic alveolitis","volume":"24","author":"Hartman","year":"2003","journal-title":"Semin Respir Crit Care Med"},{"key":"2023042408014418000_bib6"},{"key":"2023042408014418000_bib7","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1164\/ajrccm.157.4.9703022","article-title":"Idiopatic pulmonary fibrosis, predicting response to therapy and survival","volume":"157","author":"Gay","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"2023042408014418000_bib8","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1046\/j.1365-2222.2003.01603.x","article-title":"B lymphocytes in allergic alveolitis","volume":"33","year":"2003","journal-title":"Clin Exp Allergy"},{"key":"2023042408014418000_bib9","volume-title":"Diseases of the lung","author":"Constabel","year":"2003"},{"key":"2023042408014418000_bib10","volume-title":"Diseases of the lung","author":"Drent","year":"2003"},{"key":"2023042408014418000_bib11","doi-asserted-by":"crossref","first-page":"835","DOI":"10.2169\/internalmedicine.43.835","article-title":"Chronic bird fancier's lung presenting with acute exacerbation due to use of a feather duvet","volume":"43","author":"Inase","year":"2004","journal-title":"Intern Med"},{"key":"2023042408014418000_bib12","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1034\/j.1399-3038.2003.02082.x","article-title":"Treatment of allergic alveolitis with methylprednisolone pulse therapy","volume":"14","author":"Chen","year":"2003","journal-title":"Pediatr Allergy Immunol"},{"key":"2023042408014418000_bib13","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1183\/09031936.04.00101303","article-title":"Predictive value of BAL cell differentials in the diagnosis of interstitial lung diseases","volume":"24","author":"Welker","year":"2004","journal-title":"Eur Respir J"},{"key":"2023042408014418000_bib14","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0272-5231(05)70047-2","article-title":"Role of bronchoalveolar lavage in interstitial lung disease","volume":"22","author":"Baughman","year":"2001","journal-title":"Clin Chest Med"},{"key":"2023042408014418000_bib15","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1164\/ajrccm\/148.1.216","article-title":"Farmer's lung: long term outcome and lack of predictive value of bronchoalveolar lavage fibrosing factors","volume":"148","author":"Lalancette","year":"1993","journal-title":"Am Rev Resp Dis"},{"key":"2023042408014418000_bib16","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1378\/chest.108.2.464","article-title":"Immunophenotyping of lymphocytes in bronchoalveolar lavage fluid","volume":"108","author":"Thomas","year":"1995","journal-title":"Chest"},{"key":"2023042408014418000_bib17","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1378\/chest.104.1.38","article-title":"Lung fibrosis in hypersensitivity pneumonitis","volume":"104","author":"Murayama","year":"1993","journal-title":"Chest"},{"key":"2023042408014418000_bib18","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1183\/09031936.93.05010005","article-title":"Lymphocyte subsets in hypersensitivity pneumonitis","volume":"5","author":"Milburn","year":"1992","journal-title":"Eur Respir J"},{"key":"2023042408014418000_bib19","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1183\/09031936.03.00035703a","article-title":"Bronchoalveolar lavage fluid findings in children with hypersensitivity pneumonitis","volume":"21","author":"Ratjen","year":"2003","journal-title":"Eur Respir J"},{"key":"2023042408014418000_bib20","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1183\/09031936.96.09071456","article-title":"Altered immunosuppressive activity of alveolar macrophages in farmer's lung disease","volume":"9","author":"Dakhama","year":"1996","journal-title":"Eur Respir J"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/82\/971\/598\/50024513\/postgradmedj-82-598.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/82\/971\/598\/50024513\/postgradmedj-82-598.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T08:02:23Z","timestamp":1682323343000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/82\/971\/598\/7045166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,1]]},"references-count":20,"journal-issue":{"issue":"971","published-online":{"date-parts":[[2006,9,5]]},"published-print":{"date-parts":[[2006,9,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.2005.044735","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2006,9]]},"published":{"date-parts":[[2006,9,1]]}}}