{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:38:05Z","timestamp":1789907885975,"version":"4.0.1"},"reference-count":97,"publisher":"Oxford University Press (OUP)","issue":"974","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chagas disease is the clinical condition triggered by infection with the protozoan Trypanosoma cruzi. The infection is transmitted by triatomine insects while blood feeding on a human host. Field studies predict that one third of an estimated 18 million T cruzi-infected humans in Latin America will die of Chagas disease. Acute infections are usually asymptomatic, but the ensuing chronic T cruzi infections have been associated with high ratios of morbidity and mortality: Chagas heart disease leads to unexpected death in 37.5% of patients, 58% develop heart failure and die and megacolon or megaoesophagus has been associated with death in 4.5%. The pathogenesis of Chagas disease appears to be related to a parasite-induced mutation of the vertebrate genome. Currently, treatment is unsatisfactory.<\/jats:p>","DOI":"10.1136\/pgmj.2006.047357","type":"journal-article","created":{"date-parts":[[2006,12,5]],"date-time":"2006-12-05T20:13:13Z","timestamp":1165349593000},"page":"788-798","source":"Crossref","is-referenced-by-count":132,"title":["Chagas disease"],"prefix":"10.1093","volume":"82","author":[{"given":"A R L","family":"Teixeira","sequence":"first","affiliation":[{"name":"Multidisciplinary Research Laboratory, Faculty of Medicine, University of Brasilia , Federal District, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Nitz","sequence":"additional","affiliation":[{"name":"Chagas Disease Multidisciplinary Research Laboratory, University of Bras\u00edlia , Federal District, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M C","family":"Guimaro","sequence":"additional","affiliation":[{"name":"Chagas Disease Multidisciplinary Research Laboratory, University of Bras\u00edlia , Federal District, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Gomes","sequence":"additional","affiliation":[{"name":"Chagas Disease Multidisciplinary Research Laboratory, University of Bras\u00edlia , Federal District, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C A","family":"Santos-Buch","sequence":"additional","affiliation":[{"name":"Cornell University Medical College , New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,12,5]]},"reference":[{"key":"2023042408043378900_bib1","first-page":"125","volume-title":"Immune responses in parasitic infections: immunology","author":"Teixeira","year":"1987"},{"key":"2023042408043378900_bib2","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1073\/pnas.0307312101","article-title":"A 9,000-year record of Chagas' disease","volume":"101","author":"Aufderheide","year":"2004","journal-title":"Proc Natl Acd Sci USA"},{"key":"2023042408043378900_bib3","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1590\/S0074-02761909000200008","article-title":"New human trypanosomiasis. 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