{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T20:00:19Z","timestamp":1782331219631,"version":"3.54.5"},"reference-count":86,"publisher":"Oxford University Press (OUP)","issue":"1023","license":[{"start":{"date-parts":[[2010,12,3]],"date-time":"2010-12-03T00:00:00Z","timestamp":1291334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Coeliac disease (CD) remains under diagnosed with only 10\u201320% of patients identified. Genes encoding HLA DQ2 or DQ8 are found in the vast majority of those with CD and testing for their presence can be useful to rule out the possibility CD. CD is more common in certain ethnic groups including those of North Indian origin. The classical presentation tends to occur in younger children, while atypical presentations occur at an older age. The number of children being diagnosed with CD is increasing; this may be due to greater recognition of the more atypical presentations, improved serologic tests, and the screening of asymptomatic groups at increased risk, but may also be due to an overall increased prevalence. Although serologic testing has become more reliable, there still remain significant problems around testing, particularly in those &amp;lt;18\u2005months of age. All children should undergo a duodenal biopsy on a gluten containing diet in order to diagnose CD before recommending a gluten-free diet (GFD). A GFD should be offered to all children diagnosed with CD even when perceived as asymptomatic, as there is significant morbidity associated with CD later in life.<\/jats:p>","DOI":"10.1136\/pgmj.2008.075838","type":"journal-article","created":{"date-parts":[[2010,12,4]],"date-time":"2010-12-04T06:26:51Z","timestamp":1291444011000},"page":"19-25","source":"Crossref","is-referenced-by-count":14,"title":["Diagnosis and management of coeliac disease in children"],"prefix":"10.1093","volume":"87","author":[{"given":"Richard","family":"Steele","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,12,3]]},"reference":[{"key":"2023041908104564200_b1","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/MPG.0b013e31817d80f4","article-title":"Antigliadin immunoglobulin A best in finding celiac disease in children younger than 18 months of age","volume":"47","author":"Lagerqvist","year":"2008","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2023041908104564200_b2","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1093\/ajcn\/75.5.914","article-title":"Breast-feeding protects against celiac disease","volume":"75","author":"Ivarsson","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"2023041908104564200_b3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1136\/adc.2005.082016","article-title":"Effect of breast feeding on risk of coeliac disease: a systematic review and meta-analysis of observational studies","volume":"91","author":"Akobeng","year":"2006","journal-title":"Arch Dis Child"},{"key":"2023041908104564200_b4","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1001\/jama.293.19.2343","article-title":"Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease","volume":"293","author":"Norris","year":"2005","journal-title":"JAMA"},{"key":"2023041908104564200_b5","doi-asserted-by":"crossref","first-page":"247","DOI":"10.5694\/j.1326-5377.2001.tb143555.x","article-title":"High prevalence of coeliac disease in a population-based study from Western Australia: a case for screening?","volume":"175","author":"Hovell","year":"2001","journal-title":"Med J Aust"},{"key":"2023041908104564200_b6","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1046\/j.1440-1746.2000.02290.x","article-title":"Adult coeliac disease: prevalence and clinical significance","volume":"15","author":"Cook","year":"2000","journal-title":"J Gastroenterol Hepatol"},{"key":"2023041908104564200_b7","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1080\/00365529850172052","article-title":"Celiac disease risk in the USA: high prevalence of antiendomysium antibodies in healthy blood donors","volume":"33","author":"Not","year":"1998","journal-title":"Scand J Gastroenterol"},{"key":"2023041908104564200_b8","first-page":"230","article-title":"Celiac disease in India","volume":"26","author":"Yachha","year":"2007","journal-title":"Indian J Gastroenterol"},{"key":"2023041908104564200_b9","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1159\/000201035","article-title":"High risk of coeliac disease in Punjabis. 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