{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:31:49Z","timestamp":1769646709672,"version":"3.49.0"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"1023","license":[{"start":{"date-parts":[[2010,10,10]],"date-time":"2010-10-10T00:00:00Z","timestamp":1286668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Peripartum cardiomyopathy (PPCM) is a rare and potentially fatal disease which presents with symptoms of heart failure primarily due to left ventricular (LV) systolic dysfunction in the last month of pregnancy and up to 5\u20136\u2005months after delivery. PPCM is still regarded as a disease of unknown aetiology, although recent evidence suggests a role for a 16\u2005kDa prolactin derivative produced by proteolytic cleavage of prolactin secondary to unbalanced oxidative stress present during late pregnancy and early puerperium. The medical management of PPCM is similar to other forms of non-ischaemic dilated cardiomyopathy, but with the management tailored to choose safe drugs in pregnancy and lactation to minimise maternal and fetal morbidity. There is an increased risk of venous thromboembolism, and anticoagulation is recommended. About 30\u201350% of the patients recover without complications, with their baseline LV systolic function at rest returning to normal. The risk of recurrence of PPCM is high, especially if the LV systolic function has not fully recovered. However, for those women who have normal LV systolic function as demonstrated on echocardiography and dobutamine stress test, the risk of severe cardiomyopathy including death is relatively low in a subsequent pregnancy.<\/jats:p>","DOI":"10.1136\/pgmj.2009.096594","type":"journal-article","created":{"date-parts":[[2010,10,11]],"date-time":"2010-10-11T00:12:59Z","timestamp":1286755979000},"page":"34-39","source":"Crossref","is-referenced-by-count":29,"title":["Peripartum cardiomyopathy: current understanding, comprehensive management review and new developments"],"prefix":"10.1093","volume":"87","author":[{"given":"Jason R","family":"Pyatt","sequence":"first","affiliation":[{"name":"Cardiology Department, Royal Liverpool and Broadgreen University Hospitals NHS Trust , Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gopal","family":"Dubey","sequence":"additional","affiliation":[{"name":"Cardiology Department, Royal Liverpool and Broadgreen University Hospitals NHS Trust , Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,10,10]]},"reference":[{"key":"2023041908111334000_b1","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1161\/01.CIR.44.5.964","article-title":"Peripartum cardiomyopathy","volume":"44","author":"Demakis","year":"1971","journal-title":"Circulation"},{"key":"2023041908111334000_b2","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1056\/NEJM198505303122206","article-title":"Peripartum cardiomyopathy","volume":"312","author":"Homans","year":"1985","journal-title":"N Engl J Med"},{"key":"2023041908111334000_b3","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1161\/01.CIR.0000162478.36652.7E","article-title":"Pregnancy-associated cardiomyopathy: clinical characteristics and a comparison between early and late presentation","volume":"111","author":"Elkayam","year":"2005","journal-title":"Circulation"},{"key":"2023041908111334000_b4","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/00006250-198602000-00002","article-title":"Peripartum heart failure: idiopathic cardiomyopathy or compounding cardiovascular events?","volume":"67","author":"Cunningham","year":"1986","journal-title":"Obstet Gynecol"},{"key":"2023041908111334000_b5","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1161\/01.CIR.44.6.1053","article-title":"Natural course of peripartum cardiomyopathy","volume":"44","author":"Demakis","year":"1971","journal-title":"Circulation"},{"key":"2023041908111334000_b6","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1056\/NEJM198209163071207","article-title":"Peripartum cardiomyopathy due to myocarditis","volume":"307","author":"Melvin","year":"1982","journal-title":"N Engl J Med"},{"key":"2023041908111334000_b7","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/S0140-6736(88)92641-4","article-title":"Enterovirus infection in peripartum cardiomyopathy","volume":"2","author":"C\u00e9nac","year":"1988","journal-title":"Lancet"},{"key":"2023041908111334000_b8","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1161\/01.CIR.81.3.922","article-title":"Peripartum myocarditis and cardiomyopathy","volume":"81","author":"Midei","year":"1990","journal-title":"Circulation"},{"key":"2023041908111334000_b9","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ijcard.2005.02.052","article-title":"Myocardial biopsy based classification and treatment in patients with dilated cardiomyopathy","volume":"104","author":"Zimmermann","year":"2005","journal-title":"Int J Cardiol"},{"key":"2023041908111334000_b10","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ijcard.2005.11.030","article-title":"Inflammation and virus in dilated cardiomyopathy as indicated by endomyocardial biopsy","volume":"112","author":"Fett","year":"2006","journal-title":"Int J Cardiol"},{"key":"2023041908111334000_b11","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1385\/CRIAI:23:3:301","article-title":"Autoimmune mechanisms as the basis for human peripartum cardiomyopathy","volume":"23","author":"Ansari","year":"2002","journal-title":"Clin Rev Allergy Immunol"},{"key":"2023041908111334000_b12","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1001\/jama.283.9.1183","article-title":"Peripartum cardiomyopathy:National Heart, Lung and Blood Institute and Office of rare Diseases. 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