{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:41:23Z","timestamp":1788277283541,"version":"build-2803163510"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1029","license":[{"start":{"date-parts":[[2011,3,25]],"date-time":"2011-03-25T00:00:00Z","timestamp":1301011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>There are as yet no data on the prevalence of sleep apnoea in patients with severe aortic stenosis (AS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To assess the occurrence, severity and clinical correlates of sleep apnoea in patients with AS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>During a 4-month period in 2010, 67 patients were consecutively included in this study, 42 of which (19 men; mean\u00b1SD age 72\u00b19\u2005years) had severe AS (aortic valve opening area \u22641.0\u2005cm2); all were investigated with cardiorespiratory polygraphy. Sleep apnoea was diagnosed if the apnoea\u2013hypopnoea index (AHI) (median (lower quartile, upper quartile)) was \u22655\/h. The control group of 25 patients matched for age, body mass index and sex had angiographic exclusion of coronary artery disease, regular left ventricular ejection fraction, and no valve disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Sleep apnoea was found in 30\/42 patients with AS (71%; AHI=23\/h (14\/h, 36\/h)). The severity was significantly greater in patients with severe AS than in the control group (AHI=12\/h (8\/h, 17\/h)) (p&amp;lt;0.01). Half of the patients with sleep apnoea had obstructive sleep apnoea (OSA) (AHI=15\/h (9\/h, 28\/h)), and half had central sleep apnoea (CSA) (AHI=25\/h (18\/h, 45\/h)). New York Heart Association classification and severity of sleep apnoea correlated with \u03b7=0.5 (\u03b72=0.3). The severity of CSA correlated with pulmonary artery pressure (r=0.7, p&amp;lt;0.01) and pulmonary capillary wedge pressure (r=0.7, p&amp;lt;0.01). Patients with AS and CSA had a lower Pco \u00a02 than those with OSA and those without sleep apnoea (p&amp;lt;0.01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Sleep apnoea is common in patients with severe AS. The severity of CSA correlates with pulmonary hypertension, which may suggest that myocardial adaptation is exhausting.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/pgmj.2010.112052","type":"journal-article","created":{"date-parts":[[2011,3,26]],"date-time":"2011-03-26T00:15:21Z","timestamp":1301098521000},"page":"458-462","source":"Crossref","is-referenced-by-count":16,"title":["Sleep apnoea in severe aortic stenosis"],"prefix":"10.1093","volume":"87","author":[{"given":"Christian","family":"Prinz","sequence":"first","affiliation":[{"name":"Department of Cardiology, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr University Bochum , Bad Oeynhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bitter","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr University Bochum , Bad Oeynhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Oldenburg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr University Bochum , Bad Oeynhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lothar","family":"Faber","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr University Bochum , Bad Oeynhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Horstkotte","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr University Bochum , Bad Oeynhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Piper","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr University Bochum , Bad Oeynhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,3,25]]},"reference":[{"key":"2023041908322548700_b1","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1056\/NEJM199304293281704","article-title":"The occurrence of sleep-disordered breathing among middle-aged adults","volume":"328","author":"Young","year":"1993","journal-title":"N Engl J Med"},{"key":"2023041908322548700_b2","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.4065\/79.8.1036","article-title":"Obstructive sleep apnea and cardiovascular disease","volume":"79","author":"Parish","year":"2004","journal-title":"Mayo Clin Proc"},{"key":"2023041908322548700_b3","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1164\/rccm.200412-1631SO","article-title":"Pathogenesis of obstructive and central sleep apnea","volume":"172","author":"White","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"2023041908322548700_b4","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1161\/01.CIR.0000061758.05044.64","article-title":"Sleep apnea and heart failure: Part II: Central sleep apnea","volume":"107","author":"Bradley","year":"2003","journal-title":"Circulation"},{"key":"2023041908322548700_b5","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ejheart.2006.08.001","article-title":"A high prevalence of sleep disordered breathing in men with mild symptomatic chronic heart failure due to left ventricular systolic dysfunction","volume":"9","author":"Vazir","year":"2007","journal-title":"Eur J Heart Fail"},{"key":"2023041908322548700_b6","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1161\/01.CIR.99.12.1574","article-title":"Influence of pulmonary capillary wedge pressure on central apnea in heart failure","volume":"99","author":"Solin","year":"1999","journal-title":"Circulation"},{"key":"2023041908322548700_b7","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1056\/NEJM199909233411304","article-title":"A mechanism of central sleep apnea in patients with heart failure","volume":"341","author":"Javaheri","year":"1999","journal-title":"N Engl J Med"},{"key":"2023041908322548700_b8","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1056\/NEJM197610142951604","article-title":"Respiratory failure associated with familial depression of ventilator response to hypoxia and hypercapnia","volume":"295","author":"Moore","year":"1976","journal-title":"N Engl J Med"},{"key":"2023041908322548700_b9","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1513\/pats.200708-129MG","article-title":"Central sleep apnea and Cheyne-Stokes respiration","volume":"5","author":"Yumino","year":"2008","journal-title":"Proc Am Thorac Soc"},{"key":"2023041908322548700_b10","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/sleep\/22.5.667","article-title":"Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force","volume":"22","author":"Anon","year":"1999","journal-title":"Sleep"},{"key":"2023041908322548700_b11","doi-asserted-by":"crossref","first-page":"S529","DOI":"10.1097\/00004872-198812040-00166","article-title":"Is high and fluctuating muscle nerve sympathetic activity in the sleep apnoea syndrome of pathogenetic importance for the development of hypertension?","volume":"6","author":"Hedner","year":"1988","journal-title":"J Hypertens Suppl"},{"key":"2023041908322548700_b12","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1161\/CIRCULATIONAHA.107.694158","article-title":"Management of symptoms in hypertrophic cardiomyopathy","volume":"117","author":"Fifer","year":"2008","journal-title":"Circulation"},{"key":"2023041908322548700_b13","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1164\/rccm.200901-0136UP","article-title":"Update in pulmonary hypertension 2008","volume":"179","author":"Humbert","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"2023041908322548700_b14","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1183\/09031936.00084406","article-title":"Cardiorespiratory screening for sleep-disordered breathing","volume":"28","author":"Oldenburg","year":"2006","journal-title":"Eur Respir J"},{"issue":"Suppl E","key":"2023041908322548700_b15","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/eurheartj\/9.suppl_E.65","article-title":"Clinical, haemodynamic, and angiographic predictors of survival in unoperated patients with aortic stenosis","volume":"9","author":"Hammermeister","year":"1988","journal-title":"Eur Heart J"},{"key":"2023041908322548700_b16","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0735-1097(02)02002-8","article-title":"Severe pulmonary hypertension in patients with severe aortic valve stenosis: clinical profile and prognostic implications","volume":"40","author":"Malouf","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"2023041908322548700_b17","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1164\/ajrccm\/148.2.330","article-title":"Role of hyperventilation in the pathogenesis of central sleep apneas in patients with congestive heart failure","volume":"148","author":"Naughton","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"2023041908322548700_b18","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/952634","article-title":"Central sleep apnea in patients due to severe aortic stenosis","volume-title":"Case Report Med","author":"Prinz","year":"2010"},{"key":"2023041908322548700_b19","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ejheart.2006.08.003","article-title":"Sleep disordered breathing in patients with symptomatic heart failure","volume":"9","author":"Oldenburg","year":"2007","journal-title":"Eur J Heart Failure"},{"key":"2023041908322548700_b20","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1253\/circj.CJ-09-0307","article-title":"Valve repair improves central sleep apnea in heart failure patients with valvular heart diseases","volume":"73","author":"Abe","year":"2009","journal-title":"Circ J"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/87\/1029\/458\/50019279\/postgradmedj-87-458.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/87\/1029\/458\/50019279\/postgradmedj-87-458.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T08:43:04Z","timestamp":1681893784000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/87\/1029\/458\/7040818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,25]]},"references-count":20,"journal-issue":{"issue":"1029","published-online":{"date-parts":[[2011,3,25]]},"published-print":{"date-parts":[[2011,7,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.2010.112052","relation":{},"ISSN":["1469-0756","0032-5473"],"issn-type":[{"value":"1469-0756","type":"electronic"},{"value":"0032-5473","type":"print"}],"subject":[],"published-other":{"date-parts":[[2011,7]]},"published":{"date-parts":[[2011,3,25]]}}}