{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T17:40:44Z","timestamp":1684777244413},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"474","license":[{"start":{"date-parts":[[1965,4,1]],"date-time":"1965-04-01T00:00:00Z","timestamp":-149990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1965,4,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The case of a woman with a large benign villous papilloma of the rectum, presenting with sodium and water depletion and later complicated by persistent hypokalaemia, is described. The patient also suffered from primary hypogonadism and diabetes.<\/jats:p>","DOI":"10.1136\/pgmj.41.474.186","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:20:12Z","timestamp":1230582012000},"page":"186-189","source":"Crossref","is-referenced-by-count":2,"title":["Villous adenoma of the rectum with electrolyte depletion, diabetes and hypogonadism"],"prefix":"10.1093","volume":"41","author":[{"given":"J K","family":"Bamford","sequence":"first","affiliation":[{"name":"The Chelmsford Hospitals"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H-J B","family":"Galbraith","sequence":"additional","affiliation":[{"name":"The Chelmsford Hospitals"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B W T","family":"Pender","sequence":"additional","affiliation":[{"name":"The Chelmsford Hospitals"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1965,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"943","DOI":"10.7326\/0003-4819-55-6-943","volume":"55","author":"BRIGGS, G.W.","year":"1961","unstructured":"BRIGGS, G. W. (1961): Amyloidosis, Ann. intern. Med., 55, 943.","journal-title":"Amyloidosis, Ann. intern. Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1056\/NEJM195710102571502","article-title":"Acute Pancreatic Lesions in Patients Treated","volume":"257","author":"CARONE, F.A.; LIEBOW, A.A.","year":"1957","unstructured":"CARONE, F. A., and LIEBOW, A. A. (1957): Acute Pancreatic Lesions in Patients Treated with A.C.T.H. and Adrenal Corticoids, New Engl. J. Med., 257, 690.","journal-title":"and Adrenal Corticoids, New Engl. J. Med"},{"key":"ref_3","first-page":"404","volume":"30","author":"CHAPIN, L.E.; SCUDAMORE, H.H.; BAGENSTOSS, A.H.; BARGEN, I.A.","year":"1956","unstructured":"CHAPIN, L. E., SCUDAMORE, H. H., BAGENSTOSS, A. H., and BARGEN, I. A. (1956): Regional Enteritis, Associated Urinal Changes, Gastroenterology, 30, 404.","journal-title":"Regional Enteritis, Associated Urinal Changes, Gastroenterology"},{"key":"ref_4","first-page":"502","volume":"12","author":"COHEN, H.; FISHMAN, A.P.","year":"1949","unstructured":"COHEN, H., and FISHMAN, A. P. (1949): Regional Enteritis and Amyloidosis, ibid, 12, 502.","journal-title":"Regional Enteritis and Amyloidosis"},{"key":"ref_5","first-page":"702","article-title":"Acute Pancreatitis Associated with Steroid Therapy, Arch","volume":"108","author":"NELP, W.B.","year":"1961","unstructured":"NELP, W. B. (1961): Acute Pancreatitis Associated with Steroid Therapy, Arch. intern. Med., 108, 702.","journal-title":"intern. Med"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1097\/00000441-196312000-00003","article-title":"Diseases of the Liver in Regional","volume":"246","author":"PALMER, W.L.; KIRSNER, J.B.; GOLDRABER, M.B.; FUENTES, S.S.","year":"1963","unstructured":"PALMER, W. L., KIRSNER, J. B., GOLDRABER, M. B., and FUENTES, S. S. (1963): Diseases of the Liver in Regional Enteritis, Amer. J. med. Sci., 246, 663.","journal-title":"Enteritis, Amer. J. med. Sci"},{"key":"ref_7","author":"ROKER, W.; BARTLETr, M.K.","year":"1953","unstructured":"ROKER, W., and BARTLETr, M. K. (1953): Acute","journal-title":"Acute"},{"key":"ref_8","first-page":"416","volume":"29","author":"WERTHER, J.L.; SCHAPIRA, A.; RUBINSTEIN, O.; JANOwITz, H.D.","year":"1960","unstructured":"WERTHER, J. L., SCHAPIRA, A., RUBINSTEIN, O., and JANOwITz, H. D. (1960): Amyloidosis in Regional Enteritis, Amer. J. Med., 29, 416.","journal-title":"Amyloidosis in Regional Enteritis, Amer. J. Med"},{"key":"ref_9","article-title":"VILLOUS tumour of the lower bowel has been recognised as a clinical entity for over 4 century; Quain used this descriptive term when writing in 1855. However it was not until 1954 that the association of a state of severe fluid and electrolyte depletion with villous adenoma of the rectum","unstructured":"VILLOUS tumour of the lower bowel has been recognised as a clinical entity for over 4 century; Quain used this descriptive term when writing in 1855. However it was not until 1954 that the association of a state of severe fluid and electrolyte depletion with villous adenoma of the rectum"},{"key":"ref_10","first-page":"and","article-title":"BAMFORD, GALBRAITH and PENDER: Villous Adenoma i87 was first reported (McKittrick and Wheelock","volume-title":"Waugh and Moertal","volume":"Recently","author":"April","year":"1965","unstructured":"April, 1965 BAMFORD, GALBRAITH and PENDER: Villous Adenoma i87 was first reported (McKittrick and Wheelock, 1954). Recently Eisenberg, Kolb, Yam and Godt (1964) and Shamblin, Huft, Waugh and Moertal (1962) have each reported a case and between them reviewed 25 other cases described in the literature."},{"key":"ref_11","article-title":"a housewife of \u00a77 years, was admitted as an family emergency on the 10th January, 1964, the doctor suspecting that she might have had a myocardial infarction. One week previously, followmifoSblnoefhrlsgonoosartomtaadvlolnvyafogpmubruwieepseetsflpiisuopeggunrahrgregitie.nsraahedionnTsnmfedphisitessrh9dsaei0itag\/oofre6ranrrn0yhnoecnsdretmhiaanelm.of.efsbpcuTetrtshiacHhpoeceagentrm.c, icetetheiesThdosdhhantreeedoranwmcnsbyondyeaxmo, eonptsnedliuwdfcaisfeeitseodmnhurmaebe.eda-ad sequently the patient was unable to amplify this story and in particular gave no consistent account of her menstrual history. Her husband did not know whether his wife had ever menstruated or not. There were no children","author":"F, E.","unstructured":"Mrs. E. F., a housewife of \u00a77 years, was admitted as an family emergency on the 10th January, 1964, the doctor suspecting that she might have had a myocardial infarction. One week previously, followmifoSblnoefhrlsgonoosartomtaadvlolnvyafogpmubruwieepseetsflpiisuopeggunrahrgregitie.nsraahedionnTsnmfedphisitessrh9dsaei0itag\/oofre6ranrrn0yhnoecnsdretmhiaanelm.of.efsbpcuTetrtshiacHhpoeceagentrm.c,icetetheiesThdosdhhantreeedoranwmcnsbyondyeaxmo,eonptsnedliuwdfcaisfeeitseodmnhurmaebe.eda-ad sequently the patient was unable to amplify this story and in particular gave no consistent account of her menstrual history. Her husband did not know whether his wife had ever menstruated or not. There were no children."},{"key":"ref_12","article-title":"This case illustrates the difficulty in diagnosis presented by these patients who are often first seen in a state of acute peripheral circulatory failure. The presence of hypogonadism, which has not previously been described in this syndrome and which is probably coincidental, served further to confuse the diagnosis. The diabetes (the hyperglycaemia and glycosuria were present on admission and antedated the corticosteroid therapy) was probably also of no aetiological relationship to the villous adenoma or the circulatory collapse, although the patient reported by","volume-title":"had a glucose tolerance test which 'showed diabetic tendency'. The patient described by Nelson","year":"1964","unstructured":"This case illustrates the difficulty in diagnosis presented by these patients who are often first seen in a state of acute peripheral circulatory failure. The presence of hypogonadism, which has not previously been described in this syndrome and which is probably coincidental, served further to confuse the diagnosis. The diabetes (the hyperglycaemia and glycosuria were present on admission and antedated the corticosteroid therapy) was probably also of no aetiological relationship to the villous adenoma or the circulatory collapse, although the patient reported by Eisenberg and others (1964) had a glucose tolerance test which 'showed diabetic tendency'. The patient described by Nelson (1963) showed hyperglycaemia but this was noticed after intravenous glucose and hydrocortisone had been given."},{"key":"ref_13","article-title":"In addition to the 27 patients mentioned in the papers of Eisenberg and others (1964), and Shamblin and others (1962), we have found references in the literature to over 20 cases of villous tumours with serious electrolyte disturbance. It seems probable that the complication has been unrecognised rather than uncommon. It is of interest that Gabriel in 1952 mentions that 'Out of 11 cases of large benign villous tumours of the rectum treated by perineoabdominal excision there was one operative death; this occurred in a thin dehydrated patient aged 78 who died on the day after operation from cardiac failure'. Almost certainly this man suffered from the syndrome now under discussion","unstructured":"In addition to the 27 patients mentioned in the papers of Eisenberg and others (1964), and Shamblin and others (1962), we have found references in the literature to over 20 cases of villous tumours with serious electrolyte disturbance. It seems probable that the complication has been unrecognised rather than uncommon. It is of interest that Gabriel in 1952 mentions that 'Out of 11 cases of large benign villous tumours of the rectum treated by perineoabdominal excision there was one operative death; this occurred in a thin dehydrated patient aged 78 who died on the day after operation from cardiac failure'. Almost certainly this man suffered from the syndrome now under discussion."},{"key":"ref_14","article-title":"The Potassium in the Large Intestine with particular reference to the Effects of EISENBERO","author":"H","unstructured":": The Potassium in the Large Intestine with particular reference to the Effects of EISENBERO, H."},{"key":"ref_15","first-page":"604","article-title":"Villous Adenoma of the Rectum Associated with","volume":"159","author":"T.; GODT, R.","year":"1964","unstructured":"T., and GODT, R. (1964): Villous Adenoma of the Rectum Associated with Suirg., 159, 604.","journal-title":"Suirg"},{"key":"ref_16","first-page":"413","article-title":"Villous Tumours of the Rectum, Ann","volume":"6","author":"EWING, M.R.","year":"1950","unstructured":"EWING, M. R. (1950): Villous Tumours of the Rectum, Ann. Roy. Coll. Surg. Eng., 6, 413.","journal-title":"Roy. Coll. Surg. Eng"},{"key":"ref_17","first-page":"696","article-title":"The Surgical Management of Large Villous Tumours of the Rectum, Proc","volume":"45","author":"GABRIEL, W.B.","year":"1952","unstructured":"GABRIEL, W. B. (1952): The Surgical Management of Large Villous Tumours of the Rectum, Proc. roy. Soc. Med., 45, 696.","journal-title":"roy. Soc. Med"},{"key":"ref_18","article-title":"with a Potassium-Secreting Tumour of","author":"RIJSEWIJK, H.A.V.E.R.K.O.N.V.A.N.; J, M.","year":"1961","unstructured":"HAVERKON VAN RIJSEWIJK, M. J. (1961): with a Potassium-Secreting Tumour of"},{"key":"ref_19","volume":"302","author":"LITTLE, J.M.","year":"1964","unstructured":"LITTLE, J. M. (1964): Potassium Imbalance and Rectosigmoid Neoplasia, Lancet, i, 302.","journal-title":"Potassium Imbalance and Rectosigmoid Neoplasia, Lancet"},{"key":"ref_20","first-page":"61","author":"S.; WHEELOCK, F.the Colon","year":"1954","unstructured":"S., and WHEELOCK, F. the Colon, pp. 61-63, C. (1954): Springfield, Illinois: Charles C. Thomas."},{"key":"ref_21","first-page":"315","article-title":"Electrolyte and Metabolic Villous Adenoma of the Colon, Amer","volume":"14","author":"H.","year":"1963","unstructured":"H. (1963): Electrolyte and Metabolic Villous Adenoma of the Colon, Amer. J. Proctol., 14, 315.","journal-title":"J. Proctol"},{"issue":"9","key":"ref_22","first-page":"62","article-title":"Diseases of the Rectum, 2nd SHbAoMEdafMOinBEtctLRiehITo, eNnE","volume":"2","author":"QUAIN, R.","year":"1855","unstructured":"QUAIN, R. (1855): Diseases of the Rectum, 2nd SHbAoMEdafMOinBEtctLRiehITo,eNnE,,LAC,nopJn.l..oC2.nR9S.5u,,wGri.gLHt.,huo(Fn11Pr9d5r6,o62o,n)n::Jo3.1uW8VnF.ai.c,lleltdoWouAnsEUlGeaAcnHdtd,ernoMloIoyc.tbaeerMr.cDl,iiysn.toaumnrad-","journal-title":"LAC"},{"key":"ref_23","first-page":"609","article-title":"Villous Tumours of the Rectum and Colon Characterized by Severe Fluid and Electrolyte Loss, Surg","volume":"112","author":"H, M.","year":"1961","unstructured":"M. H. (1961): W., KIDD, E. G., Villous Tumours of the Rectum and Colon Characterized by Severe Fluid and Electrolyte Loss, Surg. Gynec. Obstet., 112, 609.","journal-title":"Gynec. Obstet"},{"key":"ref_24","article-title":"Villous Adenoma and of","author":"STARR, A.; MUELLER, S.","year":"1956","unstructured":"STARR, A., MUELLER, S., (1956): Villous Adenoma and of McKITrRIcK, L R."}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/41\/474\/186\/50386079\/postgradmedj-41-186.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/41\/474\/186\/50386079\/postgradmedj-41-186.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T17:12:23Z","timestamp":1684775543000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/41\/474\/186\/7036977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1965,4,1]]},"references-count":24,"journal-issue":{"issue":"474","published-online":{"date-parts":[[1965,4,1]]},"published-print":{"date-parts":[[1965,4,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.41.474.186","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1965,4]]},"published":{"date-parts":[[1965,4,1]]}}}