{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:22:53Z","timestamp":1756992173091},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"517","license":[{"start":{"date-parts":[[1968,11,1]],"date-time":"1968-11-01T00:00:00Z","timestamp":-36806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1968,11,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Experiences in the use of carbenicillin, a new penicillin active against Pseudomonas aeruginosa and other Gram-negative bacteria in the treatment of septicaemia and meningitis are described. Blood levels of carbenicillin in excess of the levels required to inhibit the infecting organisms were obtained using intravenous infusions of large doses together with probenecid by mouth. High cerebrospinal fluid levels of carbenicillin were ensured in the meningitis patients with daily intrathecal or intraventricular injections. Carbenicillin undoubtedly controlled the course of Ps. aeruginosa septicaemia in two patients.<\/jats:p>\n               <jats:p>Rapid sterilization of the cerebrospinal fluid was achieved in both meningitis patients with clinical improvement.<\/jats:p>\n               <jats:p>No evidence of toxicity was seen and daily intrathecal injections were well tolerated.<\/jats:p>","DOI":"10.1136\/pgmj.44.517.844","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:20:12Z","timestamp":1230582012000},"page":"844-847","source":"Crossref","is-referenced-by-count":16,"title":["Experiences with carbenicillin in the treatment of septicaemia and meningitis"],"prefix":"10.1093","volume":"44","author":[{"given":"A E","family":"Richardson","sequence":"first","affiliation":[{"name":"St George\u2019s Hospital Neurosurgical Unit , London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K W","family":"James","sequence":"additional","affiliation":[{"name":"Clinical Research Department, Royal Marsden Hospital , London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constance R","family":"Spittle","sequence":"additional","affiliation":[{"name":"St George\u2019s Hospital Neurosurgical Unit , London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O P W","family":"Robinson","sequence":"additional","affiliation":[{"name":"Medical Department, Beecham Research Laboratories , Brentford"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1968,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/215025a0","article-title":"New semi-synthetic penicillin active against Pseudomonas pyocyanea","volume":"215","author":"ACRED, P.; BROWN, D.M.; KNUDSEN, E.T.; ROLINSON, G.N.; SUTHERLAND, R.","year":"1967","unstructured":"ACRED, P., BROWN, D.M., KNUDSEN, E.T., ROLINSON, G.N. & SUTHERLAND, R. (1967) New semi-synthetic penicillin active against Pseudomonas pyocyanea. Nature (Lond.), 215, 25.","journal-title":"Nature (Lond.)"},{"key":"ref_2","first-page":"1289","article-title":"Clinical and laboratory studies with carbenicillin. A new penicillin active against Pseudomonas pyocyanea","volume":"i,","author":"BRumFrrr, W.; PERCIVAL, A.; LEIGH, D.A.","year":"1967","unstructured":"BRumFrrr, W., PERCIVAL, A. & LEIGH, D.A. (1967) Clinical and laboratory studies with carbenicillin. A new penicillin active against Pseudomonas pyocyanea. Lancet, i, 1289.","journal-title":"Lancet"},{"key":"ref_3","first-page":"1511","article-title":"The nature and control of infections in patients with acute leukaemia","volume":"25","author":"FREI, E.; LEVIN, R.H.; BODEY, G.P.; MORSE, E.E.; FREIREICH, E.J.","year":"1965","unstructured":"FREI, E., LEVIN, R.H., BODEY, G.P., MORSE, E.E. & FREIREICH, E.J. (1965) The nature and control of infections in patients with acute leukaemia. Cancer Res. 25, 1511.","journal-title":"Cancer Res"},{"key":"ref_4","first-page":"75","article-title":"Carbenicillin: A new semi-synthetic penicillin active against Pseudomonas pyocyanea","volume":"lii,","author":"KNUDSEN, E.T.; ROLINSON, G.N.; SUTHERLAND, R.","year":"1967","unstructured":"KNUDSEN, E.T., ROLINSON, G.N. & SUTHERLAND, R. (1967) Carbenicillin: A new semi-synthetic penicillin active against Pseudomonas pyocyanea. Brit. med. J. lii, 75.","journal-title":"Brit. med. J"},{"key":"ref_5","article-title":"Absorption and excretion of a new penicillin BRL 2064 (carbenicillin) in man. Vth International Congress of Chemotherapy. Verlag der Wiener Medizinischen Akademie","author":"ROBINSON, O.P.W.; SUTHERLAND, R.","year":"1967","unstructured":"ROBINSON, O.P.W. & SUTHERLAND, R. (1967) Absorption and excretion of a new penicillin BRL 2064 (carbenicillin) in man. Vth International Congress of Chemotherapy. Verlag der Wiener Medizinischen Akademie."}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/44\/517\/844\/50474848\/postgradmedj-44-844.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/44\/517\/844\/50474848\/postgradmedj-44-844.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T09:39:36Z","timestamp":1685439576000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/44\/517\/844\/7052002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,11,1]]},"references-count":5,"journal-issue":{"issue":"517","published-online":{"date-parts":[[1968,11,1]]},"published-print":{"date-parts":[[1968,11,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.44.517.844","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1968,11]]},"published":{"date-parts":[[1968,11,1]]}}}