{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T10:40:34Z","timestamp":1685443234449},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"518","license":[{"start":{"date-parts":[[1968,12,1]],"date-time":"1968-12-01T00:00:00Z","timestamp":-34214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1968,12,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>(1) The immediate causes of death of eighteen patients with neurosyphilitic psychosis are analysed. There were five females and thirteen males. Their average age was 56 years, and the mean length of stay in a mental hospital was approximately 2\u00bd years.<\/jats:p>\n               <jats:p>(2) Of the original ninety-one patients, twenty-eight had malaria therapy. There was one death due to malaria therapy, giving a mortality rate of 3\u00b76%. It is concluded that the risk associated with malaria is too great and fever induced by bacterial pyrogens is safer and just as effective.<\/jats:p>\n               <jats:p>(3) The duration of mental symptoms before treatment was started is analysed. In one group there was a delay of between 1 and 4 years before treatment was given. In six patients the disease ran a rapidly fatal course in spite of adequate antibiotics. Combined treatment may be beneficial in such cases as fever facilitates the penetration of penicillin into the cerebrospinal fluid.<\/jats:p>\n               <jats:p>(4) Of the four cases that came to necropsy, only one had a full pathological and histological examination of the brain and meninges. Although these four patients had profound dementia and considerable deterioration of the personality only minimal neuropathological and histological changes were found. It would seem that the widespread use of antibiotics has modified the pathological and histological picture in neurosyphilis, corresponding to alterations recently reported in the clinical features of the disease.<\/jats:p>\n               <jats:p>(5) Such adverse presenting symptoms as epilepsy, and profound dementia associated with pupillary and reflex abnormalities, are discussed.<\/jats:p>","DOI":"10.1136\/pgmj.44.518.898","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:20:12Z","timestamp":1230582012000},"page":"898-902","source":"Crossref","is-referenced-by-count":1,"title":["Clinico-pathological aspects of the neurosyphilitic psychoses"],"prefix":"10.1093","volume":"44","author":[{"given":"Kenneth","family":"Dewhurst","sequence":"first","affiliation":[{"name":"Littlemore Hospital , Oxford"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1968,12,1]]},"reference":[{"key":"ref_1","first-page":"202","article-title":"Neurosyphilis (General-Paresis). Report of a case of failure of penicillin treatment","volume":"37","author":"BIRKETT, D.A.","year":"1961","unstructured":"BIRKETT, D.A. (1961) Neurosyphilis (General-Paresis). Report of a case of failure of penicillin treatment. Brit. J. Vener. Dis. 37, 202.","journal-title":"Brit. J. Vener. Dis"},{"key":"ref_2","article-title":"Diseases of the Nervous System","author":"BRAIN, Lord","year":"1962","unstructured":"BRAIN, Lord (1962) Diseases of the Nervous System, 6th edn. Oxford University Press, London.","edition":"6th edn"},{"issue":"2","key":"ref_3","first-page":"1003","article-title":"American Handbook of Psychiatry (Ed. by Silvano Arieti)","volume":"50","author":"BRUETSCH, W.L.","year":"1959","unstructured":"BRUETSCH, W.L. (1959) American Handbook of Psychiatry (Ed. by Silvano Arieti), Chapter 50, Vol. 2, pp. 1003-1005. Basic Books, New York.","journal-title":"Chapter"},{"key":"ref_4","article-title":"Moderne Therapie der Neurosyphilis mit Einschluss der punktionstechnik und Liquoruntersuchung","author":"DATTNER, B.","year":"1933","unstructured":"DATTNER, B. (1933) Moderne Therapie der Neurosyphilis mit Einschluss der punktionstechnik und Liquoruntersuchung. Vienna."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000128958","article-title":"The use of a bacterial pyrogen in the treatment of neurosyphilis","volume":"145","author":"DEWHURST, K.","year":"1963","unstructured":"DEWHURST, K. (1963) The use of a bacterial pyrogen in the treatment of neurosyphilis. Psychiat. neurol. (Basel), 145, 18.","journal-title":"Psychiat. neurol. (Basel)"},{"key":"ref_6","article-title":"The neurosyphilitic psychoses today: A survey of 91 cases","author":"DEWHURST, K.","year":"1968","unstructured":"DEWHURST, K. (1968), The neurosyphilitic psychoses today: A survey of 91 cases. Brit. J. Psychiat. (In press).","journal-title":"Brit. J. Psychiat"},{"key":"ref_7","first-page":"257","article-title":"The effect of fever on the penetration of penicillin into the cerebrospinal fluid","volume":"1","author":"DEWHURST, K.; TODD, J.","year":"1965","unstructured":"DEWHURST, K. & TODD, J. (1965) The effect of fever on the penetration of penicillin into the cerebrospinal fluid. Int. J. Neuropsychiat. 1, 257.","journal-title":"Int. J. Neuropsychiat"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/00005053-192703000-00001","article-title":"Malaria treatment of general paresis","volume":"65","author":"FERRARO, A.; FONG, T.C.C.","year":"1927","unstructured":"FERRARO, A & FONG, T.C.C. (1927) Malaria treatment of general paresis. J. Nerv. ment. Dis. 65, 225.","journal-title":"J. Nerv. ment. Dis"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1007\/BF00216321","article-title":"Das Morphologische Bild einer Klinisch 'Geheilten Progressiven Paralyse 25 Jahre Nach der Floriden Erkankung'","volume":"165","author":"GADEKEN, R.","year":"1951","unstructured":"GADEKEN, R. (1951) Das Morphologische Bild einer Klinisch 'Geheilten Progressiven Paralyse 25 Jahre Nach der Floriden Erkankung', Dtsch. Z. Nervenheilk. 165, 482.","journal-title":"Dtsch. Z. Nervenheilk"},{"key":"ref_10","first-page":"227","article-title":"Pathologic observations of penicillintreated neurosyphilis","volume":"34","author":"GAMMON, G.D.; LEWEY, F.H.; VILLON, H.; SCHWARZ, G.; STOKES, J.H.","year":"1955","unstructured":"GAMMON, G.D., LEWEY, F.H., VILLON, H., SCHWARZ, G. & STOKES, J.H. (1955) Pathologic observations of penicillintreated neurosyphilis. Amer. J. Syph. 34, 227.","journal-title":"Amer. J. Syph"},{"key":"ref_11","article-title":"Neuropathology","author":"GREENFIELD, J.G.; BLACKWOOD, W.; MCMENEMY, W.H.; MEYER, A.; NORMAN, R.M.","year":"1961","unstructured":"GREENFIELD, J.G., BLACKWOOD, W., MCMENEMY, W.H., MEYER, A. & NORMAN, R.M. (1961) Neuropathology. Edward Arnold, London."},{"key":"ref_12","article-title":"Neurosyphilis","volume":"765","author":"HEATHFIELD, K.W.G.","year":"1968","unstructured":"HEATHFIELD, K.W.G. (1968) Neurosyphilis. Brit. med. J. i, 765.","journal-title":"Brit. med. J"},{"key":"ref_13","article-title":"Changing clinical picture of neurosyphilis. Report of seven unusual cases","volume":"211","author":"JOFFE, R.; BLACK, M.M.; FLOYD, M.","year":"1968","unstructured":"JOFFE, R., BLACK, M.M. & FLOYD, M. (1968). Changing clinical picture of neurosyphilis. Report of seven unusual cases. Brit. med. J. i, 211.","journal-title":"Brit. med. J"},{"key":"ref_14","article-title":"Neurology","volume":"1","author":"WILSON, K.I.N.N.I.E.R.; A, S.","year":"1954","unstructured":"KINNIER WILSON, S.A. (1954) Neurology (Ed. by A. Ninian Bruce), 2nd edn, Vol. 1. Butterworths, London.","edition":"2nd edn"},{"key":"ref_15","first-page":"233","article-title":"Treatment-failures following use of penicillin in late syphilis","volume":"32","author":"REYNOLDS, F.W.","year":"1948","unstructured":"REYNOLDS, F.W. (1948) Treatment-failures following use of penicillin in late syphilis. Amer. J. Syph. 32, 233.","journal-title":"Amer. J. Syph"},{"key":"ref_16","article-title":"Thalamusveranlerungen bei progressive paralyse","volume":"297","author":"SIMMA, K.","year":"1951","unstructured":"SIMMA, K. (1951) Thalamusveranlerungen bei progressive paralyse. Monatsch. Fur. psych. Neurol. 297.","journal-title":"Monatsch. Fur. psych. Neurol"},{"key":"ref_17","article-title":"The treatment of syphilis with artificial fever combined with chemo-therapy. A critical view","volume":"16","author":"SIMPSON, W.M.; KENDELL, H.W.; ROSE, D.L.","year":"1942","unstructured":"SIMPSON, W.M., KENDELL, H.W. & ROSE, D.L. (1942) The treatment of syphilis with artificial fever combined with chemo-therapy. A critical view. Suppl. No. 16 to Venereal Disease Information. Washington D.C.","journal-title":"Suppl; to Venereal Disease Information"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/44\/518\/898\/50475122\/postgradmedj-44-898.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/44\/518\/898\/50475122\/postgradmedj-44-898.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T10:08:29Z","timestamp":1685441309000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/44\/518\/898\/7051939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,12,1]]},"references-count":17,"journal-issue":{"issue":"518","published-online":{"date-parts":[[1968,12,1]]},"published-print":{"date-parts":[[1968,12,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.44.518.898","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1968,12]]},"published":{"date-parts":[[1968,12,1]]}}}