{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T21:38:40Z","timestamp":1710365920383},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"524","license":[{"start":{"date-parts":[[1969,6,1]],"date-time":"1969-06-01T00:00:00Z","timestamp":-18489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1969,6,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Herpes simplex infection of the CNS may occur as part of a generalized infection with visceral involvement or with the CNS alone involved. Aseptic meningitis due to herpes simplex is rare, but necrotizing encephalitis is being recognized with increasing frequency.<\/jats:p>\n               <jats:p>The distribution of lesions within the CNS and the mode of spread to and within the CNS are discussed.<\/jats:p>\n               <jats:p>Serological tests indicate that some cases are due to primary infection and others due to re-activation.<\/jats:p>\n               <jats:p>The importance of early diagnosis by electron and fluorescence microscopy and virus culture are discussed.<\/jats:p>\n               <jats:p>The natural history and pathogenesis of herpes simplex and B virus are discussed.<\/jats:p>","DOI":"10.1136\/pgmj.45.524.386","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:27:15Z","timestamp":1230582435000},"page":"386-391","source":"Crossref","is-referenced-by-count":9,"title":["Herpes encephalitis"],"prefix":"10.1093","volume":"45","author":[{"given":"J A","family":"Dudgeon","sequence":"first","affiliation":[{"name":"The Hospital for Sick Children, Great Ormond Street , London, W.C.1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1969,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1136\/jnnp.30.3.248","article-title":"Acute necrotizing encephalitis: a problem in diagnosis","volume":"30","author":"ADAMS, J.H.; JENNETT, W.B.","year":"1967","unstructured":"ADAMS, J.H. & JENNETT, W.B. (1967) Acute necrotizing encephalitis: a problem in diagnosis. J. Neurol. Neurosurg. Psychiat. 30, 248.","journal-title":"J. Neurol. Neurosurg. Psychiat"},{"key":"ref_2","article-title":"Viruses of Vertebrates","author":"ANDREWES, C.H.","year":"1964","unstructured":"ANDREWES, C.H. (1964) Viruses of Vertebrates, Bailliere, Tindall & Cassell, London."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.2307\/4584329","article-title":"Herpes simplex virus recovered from the spinal fluid of a suspected case of lymphocytic choriomeningitis","volume":"58","author":"ARMSTRONG, C.","year":"1943","unstructured":"ARMSTRONG, C. (1943) Herpes simplex virus recovered from the spinal fluid of a suspected case of lymphocytic choriomeningitis. Publ. Hlth Rep. (Wash.), 58, 16.","journal-title":"Publ. Hlth Rep. (Wash.)"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1136\/bmj.1.5502.1519","article-title":"Case of encephalitis due to herpes simplex","volume":"1","author":"BLACKWOOD, W.; DUDGEON, J.A.; NEWNS, G.H.; PHILLIPS, B.M.","year":"1966","unstructured":"BLACKWOOD, W., DUDGEON, J.A., NEWNS, G.H. & PHILLIPS, B.M. (1966) Case of encephalitis due to herpes simplex. Brit. med. J. 1, 1519.","journal-title":"Brit. med. J"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1136\/pgmj.45.524.382","article-title":"Herpes encephalitis","volume":"45","author":"CAMPBELL, A.M.G.","year":"1969","unstructured":"CAMPBELL, A.M.G. (1969) Herpes encephalitis. I. The clinical picture. Postgrad. med. J. 45, 382.","journal-title":"I. The clinical picture. Postgrad. med. 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Blattner), p. 95."},{"key":"ref_9","first-page":"15","article-title":"Immunization against B virus infection. I. Preparation of an experimental vaccine","volume":"71","author":"HULL, R.N.; NASH, J.C.","year":"1960","unstructured":"HULL, R.N. & NASH, J.C. (1960) Immunization against B virus infection. I. Preparation of an experimental vaccine. Amer. J. Hyg. 71, 15.","journal-title":"Amer. J. Hyg"},{"key":"ref_10","first-page":"145","article-title":"Le probleme de la meningite herpetique: contribution a son etude clinique et experimentale","volume":"50","author":"JANBON, M.; CHAPTAL, J.; LABRAQUE-BORDENAVE, M.","year":"1942","unstructured":"JANBON, M., CHAPTAL, J. & LABRAQUE-BORDENAVE, M. (1942) Le probleme de la meningite herpetique: contribution a son etude clinique et experimentale. Presse Med. 50, 145.","journal-title":"Presse Med"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/path.1700760121","article-title":"Natural virus-B infection in rhesus monkeys","volume":"76","author":"KEEBLE, S.A.; CHRISTOFINIS, G.J.; WOOD, W.","year":"1958","unstructured":"KEEBLE, S.A., CHRISTOFINIS, G.J. & WOOD, W. (1958) Natural virus-B infection in rhesus monkeys. J. Path. Bact. 76, 189.","journal-title":"J. Path. Bact"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1056\/NEJM196508122730701","article-title":"Herpes-simplex-virus encephalitis: its possible association with reactivated latent infection","volume":"273","author":"LEIDER, W.; MAGOFFIN, R.L.; LENNETTE, E.H.; LEONARDS, L.N.R.","year":"1965","unstructured":"LEIDER, W., MAGOFFIN, R.L., LENNETTE, E.H. & LEONARDS, L.N.R. (1965) Herpes-simplex-virus encephalitis: its possible association with reactivated latent infection. New Engl. J. Med. 273, 341.","journal-title":"New Engl. J. Med"},{"key":"ref_13","first-page":"17","article-title":"Generalized herpes simplex in the neonatal period","volume":"3","author":"MACCALLUM, F.O.","year":"1959","unstructured":"MACCALLUM, F.O. (1959) Generalized herpes simplex in the neonatal period. Acta. virol. 3, 17.","journal-title":"Acta"},{"key":"ref_14","article-title":"Early diagnosis of herpes-simplex encephalitis by brain biopsy","volume":"332","author":"MACCALLUM, F.O.; POTTER, J.M.; EDWARDS, D.H.","year":"1964","unstructured":"MACCALLUM, F.O., POTTER, J.M. & EDWARDS, D.H. (1964) Early diagnosis of herpes-simplex encephalitis by brain biopsy. Lancet, ii, 332.","journal-title":"Lancet"},{"key":"ref_15","first-page":"6","article-title":"Viruses as a cause of meningo-encephalitis. Virus Meningo-Encephalomyelitis","volume-title":"Ciba Foundation Study Group No","author":"MACRAE, A.D.","year":"1961","unstructured":"MACRAE, A.D. (1961) Viruses as a cause of meningo-encephalitis. Virus Meningo-Encephalomyelitis (Ed. by G. E. W. Wolstenholme and M. P. Cameron) Ciba Foundation Study Group No. 7, p. 6. Churchill, London."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1056\/NEJM196712142772401","article-title":"Herpesvirus infections of the human central nervous system","volume":"277","author":"OLSON, C.; BUESCHER, E.L.; ARTENSTEIN, M.S.; PARKMAN, P.D.","year":"1967","unstructured":"OLSON, C., BUESCHER, E.L., ARTENSTEIN, M.S. & PARKMAN, P.D. (1967) Herpesvirus infections of the human central nervous system. New Engl. J. Med. 277, 1271.","journal-title":"New Engl. J. Med"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1136\/bmj.1.5492.899","article-title":"Precautions against B virus infection","volume":"1","author":"PERKINS, F.T.; HARTLEY, E.G.","year":"1966","unstructured":"PERKINS, F.T. & HARTLEY, E.G. (1966) Precautions against B virus infection. Brit. med. J. 1, 899.","journal-title":"Brit. med. 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(1955) Sur une observation mortelle d'encephalite aigue necrosante (sa situation vis-a-vis du groupe des encephalites transmises par arthropodes et 1'encephalite herpetique). Rev. neurol."},{"key":"ref_20","first-page":"421","article-title":"Herpes simplex virus as the cause of fulminating visceral disease and hepatitis in infancy: report of eight cases and isolation of the virus in one case","volume":"83","author":"ZUELZER, W.W.; STULBERG, C.S.","year":"1952","unstructured":"ZUELZER, W.W. & STULBERG, C.S. (1952) Herpes simplex virus as the cause of fulminating visceral disease and hepatitis in infancy: report of eight cases and isolation of the virus in one case. Amer. J. Dis. Child. 83, 421.","journal-title":"Amer. J. Dis. 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