{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T16:21:57Z","timestamp":1695658917767},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"529","license":[{"start":{"date-parts":[[1969,11,1]],"date-time":"1969-11-01T00:00:00Z","timestamp":-5270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1969,11,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The insulin response to glucose was studied in twenty-five patients with pancreatic disease, of whom twelve had chronic pancreatitis, five developed glycosuria following an attack of acute pancreatitis and eight had a carcinoma of the pancreas.<\/jats:p>\n               <jats:p>A low insulin response was found in subjects with frank diabetes mellitus but in the majority of those with chronic pancreatitis the insulin response was prolonged and of normal degree. This suggests that glucose intolerance in these patients is not due to simple insulin deficiency but may be due to the release of an abnormal insulin or to insulin antagonists.<\/jats:p>\n               <jats:p>All eight patients with carcinoma of the pancreas had a low insulin response to glucose.<\/jats:p>","DOI":"10.1136\/pgmj.45.529.726","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:27:15Z","timestamp":1230582435000},"page":"726-728","source":"Crossref","is-referenced-by-count":15,"title":["The insulin response to glucose in patients with pancreatic disease"],"prefix":"10.1093","volume":"45","author":[{"given":"M T","family":"McKiddie","sequence":"first","affiliation":[{"name":"Royal Infirmary , Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G C","family":"McBain","sequence":"additional","affiliation":[{"name":"Royal Infirmary , Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K D","family":"Buchanan","sequence":"additional","affiliation":[{"name":"Royal Infirmary , Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Bell","sequence":"additional","affiliation":[{"name":"Royal Infirmary , Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1969,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1136\/pgmj.44.509.214","article-title":"Serum insulin response to glucose in pancreatic diabetics","volume":"44","author":"BANKS, S.; JACKSON, W.P.U.; KELLER, P.; MARKS, I.N.","year":"1968","unstructured":"BANKS, S., JACKSON, W.P.U., KELLER, P. & MARKS, I.N. (1968) Serum insulin response to glucose in pancreatic diabetics. Postgrad. med. J. 44, 214.","journal-title":"Postgrad. med. J"},{"key":"ref_2","first-page":"830","article-title":"Carbohydrate metabolism in jaundice","volume":"50","author":"BERKOWITZ, D.; BLINKOFF, B.; GLASSMAN, S.","year":"1966","unstructured":"BERKOWITZ, D., BLINKOFF, B. & GLASSMAN, S. (1966) Carbohydrate metabolism in jaundice. Gastroenterology, 50, 830.","journal-title":"Gastroenterology"},{"key":"ref_3","first-page":"182","article-title":"Immunoassay of Hormones; Ciba Foundation Colloquia on Endocrinology, Volume 14","author":"BERSON, S.A.; YALOW, R.S.","year":"1962","unstructured":"BERSON, S.A. & YALOW, R.S. (1962) Immunoassay of Hormones; Ciba Foundation Colloquia on Endocrinology, Volume 14, p. 182. Churchill, London."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0009-8981(67)90070-8","article-title":"Experience with the immuno-precipitation technique of insulin assay with reference to sensitivity, precision and specificity","volume":"15","author":"BUCHANAN, K.D.; McKIDDIE, M.T.","year":"1967","unstructured":"BUCHANAN, K.D. & McKIDDIE, M.T. (1967a) Experience with the immuno-precipitation technique of insulin assay with reference to sensitivity, precision and specificity. Clin. chim. Acta, 15, 315.","journal-title":"Clin. chim. Acta"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/BF01228083","article-title":"The normal insulin response to glucose. The relationship between blood sugar and plasma insulin","volume":"3","author":"BUCHANAN, K.D.; McKIDDIE, M.T.","year":"1967","unstructured":"BUCHANAN, K.D. & McKIDDIE, M.T. (1967b) The normal insulin response to glucose. The relationship between blood sugar and plasma insulin. Diabetologia, 3, 460.","journal-title":"Diabetologia"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"466","DOI":"10.2337\/diab.16.7.466","article-title":"Factors determining the plasma insulin response to oral glucose in diabetes mellitus","volume":"16","author":"BUCHANAN, K.D.; McKIDDIE, M.T.","year":"1967","unstructured":"BUCHANAN, K.D. & McKIDDIE, M.T. (1967c) Factors determining the plasma insulin response to oral glucose in diabetes mellitus. Diabetes, 16, 466.","journal-title":"Diabetes"},{"key":"ref_7","first-page":"347","article-title":"Evaluation of tests of pancreatic function in chronic pancreatic disease","author":"CHEY, W.Y.; SHAY, H.; NIELSEN, O.F.; LORHER, S.H.","year":"1967","unstructured":"CHEY, W.Y., SHAY, H., NIELSEN, O.F. & LORHER, S.H. (1967) Evaluation of tests of pancreatic function in chronic pancreatic disease. J. Amer. med. Ass. 201, 347.","journal-title":"J. Amer. med. Ass"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1001\/archinte.1948.00220200061007","article-title":"Carcinoma of the pancreas, diagnostic criteria","volume":"81","author":"DASHIELL, G.F.; PALMER, W.H.","year":"1948","unstructured":"DASHIELL, G.F. & PALMER, W.H. (1948) Carcinoma of the pancreas, diagnostic criteria. Arch. intern. Med. 81, 173.","journal-title":"Arch. intern. Med"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1042\/bj0940150","article-title":"Antagonism of insulin action on muscle by the albuminbound B chain of insulin","volume":"94","author":"ENSINCK, S.W.; MAHLER, R.S.; VALLANCE-OWEN, J.","year":"1965","unstructured":"ENSINCK, S.W., MAHLER, R.S. & VALLANCE-OWEN, J. (1965) Antagonism of insulin action on muscle by the albuminbound B chain of insulin. Biochem. J. 94, 150.","journal-title":"Biochem. J"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1042\/bj0880137","article-title":"Immunoassay of insulin with insulin-antibody precipitate","volume":"88","author":"HALES, C.N.; RANDLE, P.J.","year":"1963","unstructured":"HALES, C.N. & RANDLE, P.J. (1963) Immunoassay of insulin with insulin-antibody precipitate. Biochem. J. 88, 137.","journal-title":"Biochem. J"},{"key":"ref_11","first-page":"277","article-title":"Insulin reserve in patients with chronic pancreatitis","volume":"7","author":"JOFFE, B.I.; BANK, S.; JACKSON, W.P.U.; KELLER, P.; O'REILLY, I.G.; VINIK, Al","year":"1968","unstructured":"JOFFE, B.I., BANK, S., JACKSON, W.P.U., KELLER, P., O'REILLY, I.G. & VINIK, A.l. (1968) Insulin reserve in patients with chronic pancreatitis. Gut, 7, 277.","journal-title":"Gut"},{"key":"ref_12","first-page":"1211","article-title":"Plasma-insulin levels in 'pancreatic diabetes'","volume":"ii,","author":"KELLER, P.; BANK, S.; JACKSON, W.P.U.; MARKS, I.N.; O'REILLY, I.G.","year":"1965","unstructured":"KELLER, P., BANK, S., JACKSON, W.P.U., MARKS, I.N. & O'REILLY, I.G. (1965) Plasma-insulin levels in 'pancreatic diabetes'. Lancet, ii, 1211.","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1136\/gut.7.3.277","article-title":"Exocrine and endocrine pancreatic function in diabetes mellitus and chronic pancreatitis","volume":"7","author":"PETERS, N.; DICK, A.P.; HALES, C.N.; ORRELL, D.H.; SARNER, M.","year":"1966","unstructured":"PETERS, N., DICK, A.P., HALES, C.N., ORRELL, D.H. & SARNER, M. (1966) Exocrine and endocrine pancreatic function in diabetes mellitus and chronic pancreatitis. Gut, 7, 277.","journal-title":"Gut"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/S0140-6736(68)92040-0","article-title":"Evidence for pro-insulin in human urine and serum","volume":"i,","author":"RUBENSTEIN, A.H.; CHO, S.; STEINER, D.F.","year":"1968","unstructured":"RUBENSTEIN, A.H., CHO, S. & STEINER, D.F. (1968) Evidence for pro-insulin in human urine and serum. Lancet, i, 1353.","journal-title":"Lancet"},{"key":"ref_15","first-page":"554","article-title":"Carcinoma of the pancreas and extrahepatic biliary system","volume":"60","author":"SALMON, P.A.","year":"1966","unstructured":"SALMON, P.A. (1966) Carcinoma of the pancreas and extrahepatic biliary system. Surgery, 60, 554.","journal-title":"Surgery"},{"key":"ref_16","first-page":"1014","article-title":"Evidence that the primary lesion in diabetes mellitus is biochemical inertia of the beta cell","volume":"62","author":"SELTZER, H.S.; ALLEN, E.W.","year":"1963","unstructured":"SELTZER, H.S. & ALLEN, E.W. (1963) Evidence that the primary lesion in diabetes mellitus is biochemical inertia of the beta cell. J. Lab. dlin. Med. 62, 1014.","journal-title":"J. Lab. dlin. Med"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"547","DOI":"10.2337\/diab.17.9.547","article-title":"Plasma concentrations of A and B chains of insulin in non-diabetic, diabetic and high risk potential diabetic subjects","volume":"17","author":"VARANDANI, P.T.","year":"1968","unstructured":"VARANDANI, P.T. (1968) Plasma concentrations of A and B chains of insulin in non-diabetic, diabetic and high risk potential diabetic subjects. Diabetes, 17, 547.","journal-title":"Diabetes"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1172\/JCI104130","article-title":"Immunoassay of endogenous plasma insulin in man","volume":"39","author":"YALOW, R.S.; BERSON, S.A.","year":"1960","unstructured":"YALOW, R.S. & BERSON, S.A. (1960) Immunoassay of endogenous plasma insulin in man. J. dlin. Invest. 39, 1157.","journal-title":"J. dlin. Invest"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/45\/529\/726\/50476206\/postgradmedj-45-726.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/45\/529\/726\/50476206\/postgradmedj-45-726.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T10:22:37Z","timestamp":1685442157000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/45\/529\/726\/7051670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,11,1]]},"references-count":18,"journal-issue":{"issue":"529","published-online":{"date-parts":[[1969,11,1]]},"published-print":{"date-parts":[[1969,11,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.45.529.726","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1969,11]]},"published":{"date-parts":[[1969,11,1]]}}}