{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:24:01Z","timestamp":1760189041084},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"532","license":[{"start":{"date-parts":[[1970,2,1]],"date-time":"1970-02-01T00:00:00Z","timestamp":2678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1970,2,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Eight cases of pseudoxanthoma elasticum seen in a Medical Unit in Singapore are described. Of these six belonged to one family.<\/jats:p>\n               <jats:p>The clinical presentations of these cases, especially the first case who was a diagnostic problem for 5 years, are described. Transmission in this family is autosomal-recessive.<\/jats:p>\n               <jats:p>Eye changes were absent. Skin lesions were minimal and the axillary folds were more involved than the skin of the neck.<\/jats:p>\n               <jats:p>Of the eight cases, three were asymptomatic except for cutaneous lesions, three had suffered a haemetemesis and four a haemoptysis, while three had mental changes, and two had cerebrovascular involvement. Case 1 had in addition, bleeding from the nose, urinary tract and uterus. She also had a fatty liver, peripheral neuropathy and hysterical fits.<\/jats:p>\n               <jats:p>Only one case presented as a cosmetic problem.<\/jats:p>\n               <jats:p>The pathogenesis of PXE is discussed; the primary defect is believed to be in the elastic and not the collagenous tissue.<\/jats:p>","DOI":"10.1136\/pgmj.46.532.97","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:27:15Z","timestamp":1230582435000},"page":"97-108","source":"Crossref","is-referenced-by-count":9,"title":["Pseudoxanthoma elasticum"],"prefix":"10.1093","volume":"46","author":[{"given":"Chong Hai","family":"Tay","sequence":"first","affiliation":[{"name":"Medical Unit II, General Hospital , Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1970,2,1]]},"reference":[{"key":"ref_1","article-title":"The genetics of pseudoxanthoma elasticum","author":"BERLYNE, G.M.; BULMER, H.G.; PLATT, R.","year":"1961","unstructured":"BERLYNE, G.M., BULMER, H.G. & PLATT, R. (1961) The genetics of pseudoxanthoma elasticum. Quarterly Journal of Medicine, 30, 201.","journal-title":"Quarterly Journal of Medicine"},{"key":"ref_2","first-page":"65","article-title":"Recherches sur caracteres anatomiques du xanthelasma","volume":"4","author":"BLAZER, F.","year":"1884","unstructured":"BLAZER, F. (1884) Recherches sur caracteres anatomiques du xanthelasma. Archives de Physiologie normale et pathologique, 4, 65.","journal-title":"Archives de Physiologie normale et pathologique"},{"key":"ref_3","article-title":"Study of circulatory disturbances, pulse wave velocity and pressure pulses in larger arteries in cases of pseudoxanthoma elasticum and angioid streaks","volume":"151","author":"CARLBORG, U.","year":"1944","unstructured":"CARLBORG, U. (1944) Study of circulatory disturbances, pulse wave velocity and pressure pulses in larger arteries in cases of pseudoxanthoma elasticum and angioid streaks. Acta medica Scandinavica, Suppl. Vol. 151.","journal-title":"Acta medica Scandinavica"},{"key":"ref_4","article-title":"Vascular Studies in PXE and angioid streaks","volume":"166","author":"CARLBORG, U.; EJRUP, B.; GRONBLAD, E.; LUND, F.","year":"1959","unstructured":"CARLBORG, U., EJRUP, B., GRONBLAD, E. & LUND, F. (1959) Vascular Studies in PXE and angioid streaks. Acta medica Scandinavica, Suppl. Vol. 166.","journal-title":"Acta medica Scandinavica"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1001\/archderm.1962.01590120023004","article-title":"The significancy of angioid streaks","volume":"86","author":"CAWLEY, E.P.; WAERY, P.E.","year":"1962","unstructured":"CAWLEY, E.P. & WAERY, P.E. (1962) The significancy of angioid streaks. Archives of Dermatology, 86, 725.","journal-title":"Archives of Dermatology"},{"key":"ref_6","first-page":"412","article-title":"Xanthelasma dissemine et symmetrique sans insuffisance hepatique. Bulletin de Societe des medicins des Hopitaux de","volume":"16","author":"CHAUFFARD, A.","year":"1889","unstructured":"CHAUFFARD, A. (1889) Xanthelasma dissemine et symmetrique sans insuffisance hepatique. Bulletin de Societe des medicins des Hopitaux de Paris, 16, 412.","journal-title":"Paris"},{"key":"ref_7","first-page":"609","article-title":"Pseudoxanthoma","volume":"23","author":"DARIER, J.","year":"1896","unstructured":"DARIER, J. (1896) Pseudoxanthoma elasticum. Monatsschrift fur Praktische Dermatologie, 23, 609."},{"key":"ref_8","first-page":"128","article-title":"Choroidal and retinal changes; the results of blows on the eyes","volume":"9","author":"DOYNE, R.W.","year":"1889","unstructured":"DOYNE, R.W. (1889) Choroidal and retinal changes; the results of blows on the eyes. Transactions ofthe Ophthalmological Society of the United Kingdom, 9, 128.","journal-title":"Transactions ofthe Ophthalmological Society of the United Kingdom"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1001\/archderm.1962.01590120027005","article-title":"Pseudoxanthoma elasticum. Internal manifestations: a report of cases and a statistical review of the literature","volume":"86","author":"EDDY, D.D.; FARBER, E.E.","year":"1962","unstructured":"EDDY, D.D. & FARBER, E.E. (1962) Pseudoxanthoma elasticum. Internal manifestations: a report of cases and a statistical review of the literature. Archives of Dermatology, 86, 729.","journal-title":"Archives of Dermatology"},{"key":"ref_10","first-page":"401","article-title":"Le Syndrome de Gronblad et Strandberg","volume":"53","author":"FRANCESCHETTI, A.; ROULET, E.L.","year":"1936","unstructured":"FRANCESCHETTI, A. & ROULET, E.L. (1936) Le Syndrome de Gronblad et Strandberg. Archives d'Opthalmologie, 53, 401.","journal-title":"Archives d'Opthalmologie"},{"key":"ref_11","doi-asserted-by":"crossref","DOI":"10.1001\/archopht.1938.00850130013001","article-title":"Syndrome of Gronblad-Strandberg: Angioid Streaks in fundus oculi associated with pseudoxanthoma elasticum","volume":"19","author":"GOEDBLOED, J.","year":"1938","unstructured":"GOEDBLOED, J. (1938) Syndrome of Gronblad-Strandberg: Angioid Streaks in fundus oculi associated with pseudoxanthoma elasticum. Archives of Ophthalmology, 19.","journal-title":"Archives of Ophthalmology"},{"key":"ref_12","author":"GOODMAN, R.M.; SMITH, E.W.; PATON, D.; BERGMAN, R.A.; SIEGEL, C.L.; PUSCH, O.; MCKUSICK, V.A.","year":"1963","unstructured":"GOODMAN, R.M., SMITH, E.W., PATON, D., BERGMAN, R.A., SIEGEL, C.L., PUSCH, O. & MCKUSICK, V.A. (1963)"},{"key":"ref_13","first-page":"595","article-title":"Nouvelle note sur un cas de pseudoxanthoma elastique","volume":"4","author":"H.A.L.L.O.P.E.A.U.; L.A.F.F.I.T.T.E.","year":"1903","unstructured":"HALLOPEAU & LAFFITTE (1903) Nouvelle note sur un cas de pseudoxanthoma elastique. Annales de Dermatologie et Syphiligraphie, 4, 595.","journal-title":"Annales de Dermatologie et Syphiligraphie"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1365-2133.1951.tb13695.x","article-title":"Some clinical and pathological Notes on PXE","volume":"63","author":"HANNAY, P.W.","year":"1951","unstructured":"HANNAY, P.W. (1951) Some clinical and pathological Notes on PXE. British Journal of Dermatology, 63, 92.","journal-title":"British Journal of Dermatology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1001\/archinte.1954.00250030159019","article-title":"Elastica Disease. Case of Gronblad-Strandberg Syndrome with gastrointestinal bleeding","volume":"94","author":"KAPLAN, L.; HARTMAN, S.W.","year":"1954","unstructured":"KAPLAN, L. & HARTMAN, S.W. (1954) Elastica Disease. Case of Gronblad-Strandberg Syndrome with gastrointestinal bleeding. Archives of Internal Medicine, 94, 489.","journal-title":"Archives of Internal Medicine"},{"key":"ref_16","first-page":"289","article-title":"On the formation of dark angioid streaks as an unusual metamorphosis of retinal haemorrhage","volume":"21","author":"KNAPP, H.","year":"1892","unstructured":"KNAPP, H. (1892) On the formation of dark angioid streaks as an unusual metamorphosis of retinal haemorrhage. Archives of Ophthalmology, 21, 289.","journal-title":"Archives of Ophthalmology"},{"key":"ref_17","first-page":"609","article-title":"Pseudoxanthoma elasticum: GronbladStrandberg syndrome","volume":"76","author":"LORIA, P.R.; KENNEDY, C.B.; FREEMAN, J.A.; HENINGTON, V.M.","year":"1957","unstructured":"LORIA, P.R., KENNEDY, C.B., FREEMAN, J.A. & HENINGTON, V.M. (1957) Pseudoxanthoma elasticum: GronbladStrandberg syndrome. Archives of Dermatology, 76, 609.","journal-title":"Archives of Dermatology"},{"key":"ref_18","first-page":"156","article-title":"The Gronblad-Strandberg Syndrome: A report of 3 cases presenting with massive gastrointestinal haemorrhage during pregnancy","volume":"31","author":"MCCAUGHEY, R.S.; ALEXANDER, L.C.; MORRISH, J.A.","year":"1965","unstructured":"MCCAUGHEY, R.S., ALEXANDER, L.C. & MORRISH, J.A. (1965) The Gronblad-Strandberg Syndrome: A report of 3 cases presenting with massive gastrointestinal haemorrhage during pregnancy. Gastroenterology, 31, 156. McKusIcK, V.A. (1960) The Hereditable Disorders of Connective Tissue, 2nd edn, p. 213.","edition":"2nd edn","journal-title":"Gastroenterology; The Hereditable Disorders of Connective Tissue"},{"key":"ref_19","first-page":"688","article-title":"Studies on the nature of abnormal fibres","volume":"65","author":"Mosby, C.V.; MORAN, St Louis; J., T.; LANSING, A.I.","year":"1958","unstructured":"C. V. Mosby, St. Louis. MORAN, T.J. & LANSING, A.I. (1958) Studies on the nature of abnormal fibres. Archives of Pathology, 65, 688.","journal-title":"Archives of Pathology"},{"key":"ref_20","first-page":"94","article-title":"Pseudoxanthoma elasticum with gastrointestinal bleeding","volume":"83","author":"REINERTSON, R.P.; FARBERE, M.","year":"1955","unstructured":"REINERTSON, R.P. & FARBERE, M. (1955) Pseudoxanthoma elasticum with gastrointestinal bleeding. Califorria Medicine, 83, 94.","journal-title":"Califorria Medicine"},{"key":"ref_21","first-page":"1288","article-title":"Textbook of","volume":"2","author":"ROOK, A.; WILKINSON, D.S.; EBLING, F.J.G.","year":"1967","unstructured":"ROOK, A., WILKINSON, D.S. & EBLING, F.J.G. (1967) Textbook of Dermatology, Vol. 2, p. 1288. Blackwell Scientific Publications, Oxford and Edinburgh. SMITH, G.J. Jr, SAMS, W.M. & DAVIDSON, E.A. (1962).","journal-title":"Dermatology"},{"key":"ref_22","first-page":"689","article-title":"Pseudoxanthoma","volume":"31","author":"STRANDBERG, J.","year":"1929","unstructured":"STRANDBERG, J. (1929) Pseudoxanthoma elasticum. Zeitschrift fur Haut-und Geschlechts-Krankheiter, 31, 689."},{"key":"ref_23","first-page":"255","article-title":"L'Elastorrhexie systematis6e. Bulletin de la Societe Francaise de Dermatologie","volume":"47","author":"TOURAINE, A.","year":"1940","unstructured":"TOURAINE, A. (1940) L'Elastorrhexie systematis6e. Bulletin de la Societe Francaise de Dermatologie et Syphiligraphie, 47, 255.","journal-title":"et Syphiligraphie"},{"key":"ref_24","first-page":"315","article-title":"The fibrous structure of normal and abnormal human skin","volume":"11","author":"TUNBRIDGE, R.E.; TATTERSALL, R.N.; HALL, D.A.; ASTBURY, W.T.; REED, R.","year":"1952","unstructured":"TUNBRIDGE, R.E., TATTERSALL, R.N., HALL, D.A., ASTBURY, W.T. & REED, R. (1952) The fibrous structure of normal and abnormal human skin. Clinical Science, 11, 315.","journal-title":"Clinical Science"},{"key":"ref_25","first-page":"834","article-title":"Afwijkimgen, aan de Inwendige Organen bij Pseudoxanthoma Elasticum en Angioide Strepen","volume":"56","author":"EMBDEN, V.A.N.; A.","year":"1952","unstructured":"VAN EMBDEN, A. (1952) Afwijkimgen, aan de Inwendige Organen bij Pseudoxanthoma Elasticum en Angioide Strepen. Excelsior Photooffset Gravenhag, Groningen. WHITCOMB, F.F. & BROWN, C.H. (1962) Pesudoxanthoma elasticum. Report of 12 cases. Massive gastrointestinal haemorrhage in one patient. Annals of Internal Medicine, 56, 834.","journal-title":"Annals of Internal Medicine; Pesudoxanthoma elasticum. Report of 12 cases. Massive gastrointestinal haemorrhage in one patient"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"215","DOI":"10.7326\/0003-4819-49-1-215","article-title":"Pseudoxanthoma elasticum with gastric haemorrhage","volume":"49","author":"Woo, Jr, J.C.; CHANDLER, F.W.","year":"1958","unstructured":"Woo, J.C., Jr & CHANDLER, F.W. (1958) Pseudoxanthoma elasticum with gastric haemorrhage. Annals of Internal Medicine, 49, 215.","journal-title":"Annals of Internal Medicine"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/46\/532\/97\/50252084\/postgradmedj-46-97.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/46\/532\/97\/50252084\/postgradmedj-46-97.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T13:16:24Z","timestamp":1684156584000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/46\/532\/97\/7051583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,2,1]]},"references-count":26,"journal-issue":{"issue":"532","published-online":{"date-parts":[[1970,2,1]]},"published-print":{"date-parts":[[1970,2,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.46.532.97","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1970,2]]},"published":{"date-parts":[[1970,2,1]]}}}