{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:43:12Z","timestamp":1758818592429},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"538","license":[{"start":{"date-parts":[[1970,8,1]],"date-time":"1970-08-01T00:00:00Z","timestamp":18316800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1970,8,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Fifteen patients with hypercalcaemia and sarcoidosis have been studied. Twelve were males of average age 34; the three females averaged 53.<\/jats:p>\n               <jats:p>Cases included widely varying sarcoid manifestations, but five gave a clear history of rather excessive ingestion of low-dosage vitamin D preparations. The data confirm that in most cases there is an undue sensitivity to all the actions of vitamin D, the situation therefore mimicking vitamin D intoxication. Two patients volunteered to receive ultra-violet irradiation and became hypercalcaemic with corresponding clinical and biochemical changes.<\/jats:p>\n               <jats:p>Steroids make normal the calcium abnormalities just as they do in straight vitamin D intoxication. However, in three further patients the hypercalcaemia did not respond to steroids and was shown to be due to the presence of an over-acting parathyroid gland, removal of which corrected the abnormality. There are a sufficient number of other similar cases in the literature to suggest that the development of parathyroid adenomas is another even rarer complication of sarcoidosis which must be carefully distinguished from vitamin D sensitivity.<\/jats:p>","DOI":"10.1136\/pgmj.46.538.471","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:27:15Z","timestamp":1230582435000},"page":"471-473","source":"Crossref","is-referenced-by-count":19,"title":["Calcium metabolism in sarcoidosis"],"prefix":"10.1093","volume":"46","author":[{"given":"C E","family":"Dent","sequence":"first","affiliation":[{"name":"Medical Unit, University College Hospital Medical School , London, W.C.1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1970,8,1]]},"reference":[{"key":"ref_1","article-title":"Presented at the VIIIth Middle East Medical Assembly, Beirut","volume-title":"1958 and reproduced by permission","year":"11 May","unstructured":"(Presented at the VIIIth Middle East Medical Assembly, Beirut, 11 May 1958 and reproduced by permission.)"},{"key":"ref_2","article-title":"differential diagnosis of hypercalcaemia using the equivalent dose of 40 mg 8-hourly for 10 days","year":"1968","unstructured":"differential diagnosis of hypercalcaemia using the equivalent dose of 40 mg 8-hourly for 10 days (Dent & Watson, 1968)."},{"key":"ref_3","article-title":"Effect of cortisone on calcium metabolism in sarcoidosis with hypercalcaemia. Possibly antagonistic actions of cortisone and vitamin D","volume":"720","author":"ANDERSON, J.; DENT, C.E.; HARPER, C.; PHILPOT, G.R.","year":"1954","unstructured":"ANDERSON, J., DENT, C.E., HARPER, C. & PHILPOT, G.R. (1954) Effect of cortisone on calcium metabolism in sarcoidosis with hypercalcaemia. Possibly antagonistic actions of cortisone and vitamin D. Lancet, ii, 720.","journal-title":"Lancet"},{"key":"ref_4","author":"AVIOLI, L.V.; BIRGE, S.; LEE, S.E.; SLATOPOLSKY, E.","year":"1968","unstructured":"AVIOLI, L.V., BIRGE, S., LEE, S.E. & SLATOPOLSKY, E. (1968)"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1172\/JCI105909","article-title":"The metabolic fate of vitamin D3-3H in chronic renal failure","volume":"47","author":"BLUNT, J.W.","year":"1968","unstructured":"The metabolic fate of vitamin D3-3H in chronic renal failure. Journal of Clinical Investigation, 47, 2239. BLUNT, J.W., DE LUCA, H.F. & SCHNOES, H.K. (1968) 25-","journal-title":"Journal of Clinical Investigation"},{"key":"ref_6","series-title":"Proceedings of the 8th Middle East Medical Assembly, Beirut","first-page":"162","author":"DENT, C.E.","year":"1958","unstructured":"DENT, C.E. (1958) Proceedings of the 8th Middle East Medical Assembly, Beirut, p. 162."},{"key":"ref_7","article-title":"Hyperparathyroidism and sarcoidosis","volume":"i","author":"DENT, C.E.; WATSON, L.","year":"1966","unstructured":"DENT, C.E. & WATSON, L. (1966) Hyperparathyroidism and sarcoidosis. British Medical Journal, i, 646-649. DENT, C.E. & WATSON, L. (1968) The hydrocortisone test in primary and tertiary hyperparathyroidism. Lancet, ii, 662.","journal-title":"British Medical Journal; The hydrocortisone test in primary and tertiary hyperparathyroidism"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1172\/JCI103378","article-title":"The cause of hypercalciuria in sarcoid and its treatment with cortisone and sodium phytate","volume":"35","author":"HENNEMAN, P.H.; DEMPSEY, E.F.; CARROLL, E.L.; F, A.L.B.R.I.G.H.T.","year":"1956","unstructured":"HENNEMAN, P.H., DEMPSEY, E.F., CARROLL, E.L. & ALBRIGHT F. (1956) The cause of hypercalciuria in sarcoid and its treatment with cortisone and sodium phytate. Journal of Clinical Investigation, 35, 1229-42.","journal-title":"Journal of Clinical Investigation"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/46\/538\/471\/49299879\/postgradmedj-46-471.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/46\/538\/471\/49299879\/postgradmedj-46-471.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T13:30:13Z","timestamp":1681997413000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/46\/538\/471\/7051629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,8,1]]},"references-count":8,"journal-issue":{"issue":"538","published-online":{"date-parts":[[1970,8,1]]},"published-print":{"date-parts":[[1970,8,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.46.538.471","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1970,8]]},"published":{"date-parts":[[1970,8,1]]}}}