{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:01:24Z","timestamp":1761058884474},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"552","license":[{"start":{"date-parts":[[1971,10,1]],"date-time":"1971-10-01T00:00:00Z","timestamp":55123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1971,10,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Two hundred and twenty-seven cases of moderate to severe hypertension were treated with thiazide diuretics alone for periods of up to 12 years. In 80% the hypertension was adequately controlled without additional antihypertensive agents.<\/jats:p>\n               <jats:p>Hypokalaemic alkalosis was common despite potassium supplements\u2014but caused no symptoms. The incidence of diabetes and gout was low.<\/jats:p>\n               <jats:p>It is concluded that thiazide diuretics provide excellent control of hypertension with very few side effects.<\/jats:p>","DOI":"10.1136\/pgmj.47.552.639","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:27:15Z","timestamp":1230582435000},"page":"639-643","source":"Crossref","is-referenced-by-count":45,"title":["The long-term treatment of hypertension with thiazide diuretics"],"prefix":"10.1093","volume":"47","author":[{"given":"D G","family":"Beevers","sequence":"first","affiliation":[{"name":"Chelmsford Group of Hospitals"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Chelmsford Group of Hospitals"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J E","family":"Harpur","sequence":"additional","affiliation":[{"name":"Chelmsford Group of Hospitals"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1971,10,1]]},"reference":[{"key":"ref_1","article-title":"Hypertension and hyperuricaemia","volume":"15","author":"BRECKENRIDGE, A.","year":"1966","unstructured":"BRECKENRIDGE, A. (1966) Hypertension and hyperuricaemia. Lancet, i, 15.","journal-title":"Lancet"},{"key":"ref_2","first-page":"966","article-title":"Effects of oral diuretics on raised arterial pressure","volume":"ii,","author":"CRANSTON, W.I.; JUEL-JENSEN, B.E.; SEMMENCE, A.M.; JONES, H.A.N.D.F.I.E.L.D.; C., R.P.; FORBES, J.A.; MUTCH, L.M.M.","year":"1963","unstructured":"CRANSTON, W.I., JUEL-JENSEN, B.E., SEMMENCE, A.M., HANDFIELD JONES, R.P.C., FORBES, J.A. & MUTCH, L.M.M. (1963) Effects of oral diuretics on raised arterial pressure. Lancet, ii, 966.","journal-title":"Lancet"},{"key":"ref_3","first-page":"735","article-title":"Drug-induced diabetes","volume":"ii,","author":"DOLLERY, C.T.; PENTECOST, B.L.; SAMAAN, N.A.","year":"1962","unstructured":"DOLLERY, C.T., PENTECOST, B.L. & SAMAAN, N.A. (1962) Drug-induced diabetes. Lancet, ii, 735.","journal-title":"Lancet"},{"key":"ref_4","first-page":"196","article-title":"Symposium on Antihypertensive Therapy","author":"HAMILTON, M.","year":"1966","unstructured":"HAMILTON, M. (1966) Symposium on Antihypertensive Therapy, pp. 196-206. Springer Verlag, Berlin."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1136\/pgmj.44.507.66","article-title":"Some aspects of the long-term treatment of severe hypertension with methyl dopa","volume":"44","author":"HAMILTON, M.","year":"1968","unstructured":"HAMILTON, M. (1968) Some aspects of the long-term treatment of severe hypertension with methyl dopa. Postgraduate Medical Journal, 44, 66.","journal-title":"Postgraduate Medical Journal"},{"key":"ref_6","first-page":"716","article-title":"Body composition changes in hypertensive subjects on long-term diuretic therapy","volume":"1","author":"HEALY, J.J.; MCKENNA, T.J.; CANNING, B.S.T.J.; BRIEN, T.G.; DUFFY, G.J.; MULDOWNEY, F.","year":"1970","unstructured":"HEALY, J.J., MCKENNA, T.J., CANNING, B.ST.J., BRIEN, T.G., DUFFY, G.J. & MULDOWNEY, F.P (1970) Body composition changes in hypertensive subjects on long-term diuretic therapy. British Medical Journal, 1, 716.","journal-title":"P"},{"key":"ref_7","first-page":"p.","article-title":"Catapres in Hypertension","author":"KELLETT, R.J.; HAMILTON, M.","year":"1969","unstructured":"KELLETT, R.J. & HAMILTON, M. (1969) Catapres in Hypertension, p. 197. Butterworths, London."},{"key":"ref_8","first-page":"107","article-title":"Diabetogenic effect of long-term diuretic therapy. Symposium of the Seventh Congress of International Diabetes Federation","author":"KOHNER, E.M.; DOLLERY, C.T.; Lowy, C.; SCHUMER, B.; SAMUELS, C.","year":"1970","unstructured":"KOHNER, E.M., DOLLERY, C.T., Lowy, C., SCHUMER, B. & SAMUELS, C. (1970) Diabetogenic effect of long-term diuretic therapy. Symposium of the Seventh Congress of International Diabetes Federation, 23 August, p. 107."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/0002-8703(69)90252-X","article-title":"Potassium loss with thiazide therapy","volume":"16","author":"MARONDE, R.F.; MILGROM, M.; DICKEY, J.M.","year":"1969","unstructured":"MARONDE, R.F., MILGROM, M. & DICKEY, J.M. (1969) Potassium loss with thiazide therapy. American Heart Journal, 16, 16.","journal-title":"American Heart Journal"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/47\/552\/639\/50252485\/postgradmedj-47-639.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/47\/552\/639\/50252485\/postgradmedj-47-639.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T07:18:29Z","timestamp":1684221509000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/47\/552\/639\/7051371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,10,1]]},"references-count":9,"journal-issue":{"issue":"552","published-online":{"date-parts":[[1971,10,1]]},"published-print":{"date-parts":[[1971,10,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.47.552.639","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1971,10]]},"published":{"date-parts":[[1971,10,1]]}}}