{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:46:33Z","timestamp":1756993593861},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"553","license":[{"start":{"date-parts":[[1971,11,1]],"date-time":"1971-11-01T00:00:00Z","timestamp":57801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1971,11,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>It is generally accepted that patients suffering from Mycobacterium tuberculosis infections show positive tuberculin skin tests, with certain rare exceptions. Recognized causes of these exceptions include extreme illness, whether due to extensive tuberculosis or to other severe disease, and certain viral infections, notably measles. It is not so generally recognized that a few patients with pulmonary tuberculosis, generally of rather indolent type, who are not acutely ill, persistently fail to react to tuberculin; and that the range of tuberculin sensitivity observed in patients with the more usual forms of tuberculosis is very wide.<\/jats:p><jats:p>The effect of cortisone in diminishing the size of tuberculin reactions in patients with pulmonary tuberculosis is directly related to the degree of sensitivity; reactions produced by small doses of tuberculin in patients with high sensitivity are greatly diminished or inhibited, while those produced by 100 T.U. in patients with low sensitivity are not significantly altered. Patients with tuberculosis can be desensitized to tuberculin by increasing injections of tuberculin under chemotherapy cover. In patients who have been so desensitized, the addition of cortisone to tuberculin in an intradermal test produces positive reactions in 70%. Among patients with sarcoidosis giving no reaction to 100 T.U., about half react when cortisone is added.<\/jats:p><jats:p>These observations show that in patients with sarcoidosis, a negative tuberculin test cannot be taken to exclude M. tuberculosis infection.<\/jats:p>","DOI":"10.1136\/pgmj.47.553.694","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:27:15Z","timestamp":1230582435000},"page":"694-697","source":"Crossref","is-referenced-by-count":3,"title":["Tuberculin sensitivity in tuberculosis"],"prefix":"10.1093","volume":"47","author":[{"given":"J G","family":"Scadding","sequence":"first","affiliation":[{"name":"Institute of Diseases of the Chest, Brompton Hospital , London, S.W.3"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1971,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1056\/NEJM196412172712505","article-title":"Depression of tuberculin sensitivity by viral vaccines","volume":"271","author":"BRODY, J.; OVERFIELD, T.; HAMES, L.","year":"1964","unstructured":"BRODY, J., OVERFIELD, T. & HAMES, L. (1964) Depression of tuberculin sensitivity by viral vaccines. New England Journal of Medicine, 271, 1294.","journal-title":"New England Journal of Medicine"},{"key":"ref_2","first-page":"277","article-title":"The effect of cortisone upon the reaction of the skin to tuberculin in tuberculosis and in sarcoidosis","volume":"26","author":"CITRON, K.M.; SCADDING, J.G.","year":"1957","unstructured":"CITRON, K.M. & SCADDING, J.G. (1957) The effect of cortisone upon the reaction of the skin to tuberculin in tuberculosis and in sarcoidosis. Quarterly Journal of Medicine, 26, 277.","journal-title":"Quarterly Journal of Medicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1136\/bmj.2.5196.433","article-title":"Cortisone and skin sensitivity to tuberculin in reticuloses","volume":"2","author":"FAIRLEY, G.H.; MATrHIAS, J.Q.","year":"1960","unstructured":"FAIRLEY, G.H. & MATrHIAS, J.Q. (1960) Cortisone and skin sensitivity to tuberculin in reticuloses. British Medical Journal, 2, 433.","journal-title":"British Medical Journal"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1378\/chest.57.6.530","article-title":"The loss of tuberculin sensitivity in certain patients with active pulmonary tuberculosis","volume":"57","author":"HOWARD, W.L.; KLOPFENSTEIN, M.D.; STEININGER, W.J.; WOODRUFF, C.E.","year":"1970","unstructured":"HOWARD, W.L., KLOPFENSTEIN, M.D., STEININGER, W.J. & WOODRUFF, C.E. (1970) The loss of tuberculin sensitivity in certain patients with active pulmonary tuberculosis. Chest, 57, 530.","journal-title":"Chest"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0140-6736(54)90139-7","article-title":"Skin sensitivity in sarcoidosis","volume":"ii,","author":"HOYLE, C.; DAWSON, J.; MATHER, G.","year":"1954","unstructured":"HOYLE, C., DAWSON, J. & MATHER, G. (1954) Skin sensitivity in sarcoidosis. Lancet, ii, 164.","journal-title":"Lancet"},{"key":"ref_6","article-title":"Miliary and meningeal tuberculosis: difficulties in diagnosis","volume":"646","author":"ILLINGWORTH, R.S.","year":"1956","unstructured":"ILLINGWORTH, R.S. (1956) Miliary and meningeal tuberculosis: difficulties in diagnosis. Lancet, ii, 646.","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1136\/bmj.2.5359.720","article-title":"Declining tuberculin sensitivity with advancing age","volume":"2","author":"JOHNSTON, R.; RITCHIE, R.; MURRAY, L.","year":"1963","unstructured":"JOHNSTON, R., RITCHIE, R. & MURRAY, L. (1963) Declining tuberculin sensitivity with advancing age. 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(1951) The Pathogenesis of Tuberculosis, 2nd edn. Blackwell Scientific Publications, Oxford and Edinburgh.","edition":"2nd edn"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0041-3879(56)80181-5","article-title":"Insensitivity to tuberculin in pulmonary tuberculosis","volume":"37","author":"SCADDING, J.G.","year":"1956","unstructured":"SCADDING, J.G. (1956) Insensitivity to tuberculin in pulmonary tuberculosis. Tubercle, 37, 371.","journal-title":"Tubercle"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1136\/bmj.2.5213.1617","article-title":"M. tuberculosis in the aetiology of sarcoidosis","volume":"2","author":"SCADDING, J.G.","year":"1960","unstructured":"SCADDING, J.G. (1960) M. tuberculosis in the aetiology of sarcoidosis. 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(1934) Etiology of Hodgkin's disease: skin reactions to avian and human tuberculin proteins in Hodgkin's disease. 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