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The drug was found to be safe and moderately effective when used alone, but combined with frusemide it proved to be of great value in patients whose fluid retention was refractory to other diuretics.<\/jats:p>","DOI":"10.1136\/pgmj.47.554.789","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:27:15Z","timestamp":1230582435000},"page":"789-793","source":"Crossref","is-referenced-by-count":34,"title":["Clinical experience with metolazone in fifty-two African patients: synergy with frusemide"],"prefix":"10.1093","volume":"47","author":[{"given":"R F","family":"Gunstone","sequence":"first","affiliation":[{"name":"Department of Medicine, Mulago Hospital and Makerere University Medical School , Kampala , Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H G P","family":"Shani","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mulago Hospital and Makerere University Medical School , Kampala , Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Njemo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mulago Hospital and Makerere University Medical School , Kampala , Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Wing","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mulago Hospital and Makerere University Medical School , Kampala , Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E M W","family":"Sabuka","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mulago Hospital and Makerere University Medical School , Kampala , Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1975,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3181\/00379727-131-33869","article-title":"Antagonism to the diuretic action of SR 720-22 (33869)","volume":"131","author":"BELAIR, E.J.; BORELLI, A.R.; YELNOSKY, J.","year":"1969","unstructured":"BELAIR, E.J., BORELLI, A.R. & YELNOSKY, J. 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(1970) The lymphatics, pancreatic ascites and pancreatic inflammatory disease. American Journal of Gastroenterology, 53, 119.","journal-title":"American Journal of Gastroenterology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0022-3565(25)27018-5","article-title":"Addition of the saluretic action of furosemide to the saluretic action of certain other agents","volume":"148","author":"HOOK, J.B.; WILLIAMSON, H.E.","year":"1965","unstructured":"HOOK, J.B. & WILLIAMSON, H.E. (1965) Addition of the saluretic action of furosemide to the saluretic action of certain other agents. Journal of Pharmacology and Experimental Therapeutics, 148, 88.","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"ref_5","first-page":"439","article-title":"Observations of renal function in patients undergoing therapeutic diuresis with frusemide","volume":"38","author":"HUTT, M.S.R.","year":"1971","unstructured":"HUTT, M.S.R. 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