{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:39:01Z","timestamp":1760204341038},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"555","license":[{"start":{"date-parts":[[1972,1,1]],"date-time":"1972-01-01T00:00:00Z","timestamp":63072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1972,1,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Cryptococcosis, a disease of world-wide distribution, is uncommon in the British Isles where it usually presents as meningitis affecting patients with malignant disease of the reticulo-endothelial system, diabetes mellitus or those receiving systemic treatment with corticosteroids. The clinical features and physical signs of the disease are often non-specific and resemble those of tuberculous meningitis. The diagnosis is made upon recognizing the encapsulated Cryptococcus neoformans on Indian Ink preparations of the cerebrospinal fluid, or by demonstrating precipitating antibodies to the organism in the patient's serum. The treatment is by intravenous administration of amphotericin B for a period of 6\u201312 weeks, supplemented in severe or relapsing cases by intrathecal therapy; alternatively, 5-fluorocytosine may be given by mouth. A case is reported of cryptococcal meningitis occurring in a 46-year-old woman with systemic lupus erythematosus treated with methylprednisolone. Treatment with amphotericin B was successful in suppressing the infection, but was accompanied by side-effects and some temporary impairment of renal function.<\/jats:p>","DOI":"10.1136\/pgmj.48.555.52","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:27:15Z","timestamp":1230582435000},"page":"52-55","source":"Crossref","is-referenced-by-count":20,"title":["Cryptococcal meningitis as a complication of systemic lupus erythematosus treated with systemic corticosteroids"],"prefix":"10.1093","volume":"48","author":[{"given":"J V","family":"Collins","sequence":"first","affiliation":[{"name":"Guys Hospital , London, S.E. 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Tong","sequence":"additional","affiliation":[{"name":"Guys Hospital , London, S.E. 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R G","family":"Bucknall","sequence":"additional","affiliation":[{"name":"Guy's Hospital London, S.E.1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A P","family":"Warin","sequence":"additional","affiliation":[{"name":"St Nicholas' Hospital , Plumstead, London, S.E.18"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1972,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1056\/NEJM196401092700201","article-title":"Diagnostic and prognostic value of clinical and laboratory findings in cryptococcal meningitis","volume":"270","author":"BUTLER, W.T.; ALLING, D.W.; SPICKARD, A.; UTZ, J.P.","year":"1964","unstructured":"BUTLER, W.T., ALLING, D.W., SPICKARD, A. & UTZ, J.P. (1964) Diagnostic and prognostic value of clinical and laboratory findings in cryptococcal meningitis. New England Journal of Medicine, 270, 59.","journal-title":"New England Journal of Medicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0002-9343(68)90075-2","article-title":"Treatment of disseminated mycotic infections: A new approach to amphotericin B therapy","volume":"45","author":"DRUTZ, D.J.; SPICKARD, A.; ROGERS, D.E.; KOENIG, M.G.","year":"1968","unstructured":"DRUTZ, D.J., SPICKARD, A., ROGERS, D.E. & KOENIG, M.G. (1968) Treatment of disseminated mycotic infections: A new approach to amphotericin B therapy. American Journal of Medicine, 45, 405.","journal-title":"American Journal of Medicine"},{"key":"ref_3","first-page":"227","article-title":"Saprophytic sources of Cryptoccus neoformans associated with the pigeon (Columba livia)","volume":"62","author":"EMMONS, C.W.","year":"1955","unstructured":"EMMONS, C.W. (1955) Saprophytic sources of Cryptoccus neoformans associated with the pigeon (Columba livia). American Journal of Hygiene, 62, 227.","journal-title":"American Journal of Hygiene"},{"key":"ref_4","first-page":"579","article-title":"Amphotericins A and B, antifungal antibiotics produced by a streptomycete. In vitro studies","author":"GOLD, W.; STOUT, H.A.; PAGANO, J.F.; DONOBICK, R.","year":"1956","unstructured":"GOLD, W., STOUT, H.A., PAGANO, J.F. & DONOBICK, R. (1956) Amphotericins A and B, antifungal antibiotics produced by a streptomycete. In vitro studies. In: Antibiotics Annual (Ed. by H. Welch & F. Marti-Ibanez), p. 579. Medical Encyclopedia, Inc., New York."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1001\/jama.1966.03110120067016","article-title":"Serologic tests in diagnosis and prognosis of cryptococcosis","author":"GORDON, M.A.; VEDDER, D.K.","year":"1966","unstructured":"GORDON, M.A. & VEDDER, D.K. (1966) Serologic tests in diagnosis and prognosis of cryptococcosis. Journal of American Medical Association, 197, 961.","journal-title":"Journal of American Medical Association"},{"key":"ref_6","first-page":"222","article-title":"Cryptococcosis: current status","volume":"45","author":"LITTMAN, M.L.; WALTER, J.E.","year":"1968","unstructured":"LITTMAN, M.L. & WALTER, J.E. (1968) Cryptococcosis: current status. American Journal of Medicine, 45, 222.","journal-title":"American Journal of Medicine"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1056\/NEJM196801182780302","article-title":"Renal tubular acidosis due to amphotericin B","volume":"278","author":"MCCURDY, D.K.; FREDERIC, M.; ELKINTON, J.R.","year":"1968","unstructured":"MCCURDY, D.K., FREDERIC, M. & ELKINTON, J.R. (1968) Renal tubular acidosis due to amphotericin B. New England Journal of Medicine, 278, 124.","journal-title":"New England Journal of Medicine"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/S0140-6736(66)92330-0","article-title":"Cryptococcus neoformans in bird droppings","volume":"ii,","author":"PARTRIDGE, B.M.; WINNER, H.I.","year":"1966","unstructured":"PARTRIDGE, B.M. & WINNER, H.I. (1966) Cryptococcus neoformans in bird droppings. Lancet, ii, 1251.","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/208801a0","article-title":"Isolation of Cryptococcus neoformans from pigeon habitats in London","volume":"208","author":"RANDHAWA, H.S.; CLAYTON, Y.M.; RIDDELL, R.W.","year":"1965","unstructured":"RANDHAWA, H.S., CLAYTON, Y.M. & RIDDELL, R.W. (1965) Isolation of Cryptococcus neoformans from pigeon habitats in London. Nature (London), 208, 801.","journal-title":"Nature (London)"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/path.1700330208","article-title":"Fatal granulomatosis of the central nervous system due to a yeast (Torula)","volume":"33","author":"SMITH, F.B.; CRAWFORD, J.S.","year":"1930","unstructured":"SMITH, F.B. & CRAWFORD, J.S. (1930) Fatal granulomatosis of the central nervous system due to a yeast (Torula). Journal of Pathology and Bacteriology, 33, 291.","journal-title":"Journal of Pathology and Bacteriology"},{"key":"ref_11","article-title":"Cryptococcus neoformans in bird droppings","volume":"159","author":"SYMMERS, W.S.T.C.","year":"1967","unstructured":"SYMMERS, W.ST.C. (1967) Cryptococcus neoformans in bird droppings. Lancet, i, 159.","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1136\/bmj.3.5661.29","article-title":"Two cases of cryptococcal meningitis, one treated with 5-fluorocytosine","volume":"3","author":"WATKINS, J.S.; CAMPBELL, M.J.; GARDNER-MEDWIN, D.; INGHAM, H.R.; MURRAY, I.G.","year":"1969","unstructured":"WATKINS, J.S., CAMPBELL, M.J., GARDNER-MEDWIN, D., INGHAM, H.R. & MURRAY, I.G. (1969) Two cases of cryptococcal meningitis, one treated with 5-fluorocytosine. British Medical Journal, 3, 29.","journal-title":"British Medical Journal"},{"key":"ref_13","first-page":"951","article-title":"Treatment of mycotic meningitis","volume":"4","author":"WILLIAMS, T.W.","year":"1967","unstructured":"WILLIAMS, T.W. (1967) Treatment of mycotic meningitis. Modern Treatment, 4, 951.","journal-title":"Modern Treatment"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1136\/jcp.23.8.657","article-title":"Cryptococcal meningitis associated with steroid therapy","volume":"23","author":"WILSON, T.S.; FLEMING, W.A.; ROBINSON, F.L.J.; NICHOLL, B.","year":"1970","unstructured":"WILSON, T.S., FLEMING, W.A., ROBINSON, F.L.J. & NICHOLL, B. (1970) Cryptococcal meningitis associated with steroid therapy. Journal of Clinical Pathology, 23, 657.","journal-title":"Journal of Clinical Pathology"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/48\/555\/52\/50252783\/postgradmedj-48-52.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/48\/555\/52\/50252783\/postgradmedj-48-52.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T08:15:57Z","timestamp":1684224957000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/48\/555\/52\/7064443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,1,1]]},"references-count":14,"journal-issue":{"issue":"555","published-online":{"date-parts":[[1972,1,1]]},"published-print":{"date-parts":[[1972,1,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.48.555.52","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1972,1]]},"published":{"date-parts":[[1972,1,1]]}}}