{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:31:26Z","timestamp":1759541486556},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"559","license":[{"start":{"date-parts":[[1972,5,1]],"date-time":"1972-05-01T00:00:00Z","timestamp":73526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1972,5,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The case records of 262 patients who received 131I therapy during a 6-year period were analysed retrospectively. These included seventy-eight patients who received more than one therapeutic dose.<\/jats:p>\n               <jats:p>The major indication for 131I therapy was thyrotoxicosis occurring in patients aged 40 years and over. The racial incidence in this series is striking.<\/jats:p>\n               <jats:p>The effects on thyroid function of two low-dose schedules (4 mCi and 6 mCi) were compared. The major complication encountered was hypothyroidism. 4 mCi appears to be as effective as 6 mCi with the added advantage of producing less hypothyroidism.<\/jats:p>","DOI":"10.1136\/pgmj.48.559.308","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:27:15Z","timestamp":1230582435000},"page":"308-313","source":"Crossref","is-referenced-by-count":9,"title":["Radioactive iodine (131I) therapy for thyrotoxicosis at Groote Schuur Hospital over a 6-year period"],"prefix":"10.1093","volume":"48","author":[{"given":"J","family":"Sagel","sequence":"first","affiliation":[{"name":"Thyroid Clinic and Endocrine Research Group, Department of Medicine, University of Cape Town and Groote Schuur Hospital , Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Epstein","sequence":"additional","affiliation":[{"name":"Thyroid Clinic and Endocrine Research Group, Department of Medicine, University of Cape Town and Groote Schuur Hospital , Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Kalk","sequence":"additional","affiliation":[{"name":"Thyroid Clinic and Endocrine Research Group, Department of Medicine, University of Cape Town and Groote Schuur Hospital , Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Van Mieghem","sequence":"additional","affiliation":[{"name":"Department of Medicine , Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1972,5,1]]},"reference":[{"key":"ref_1","first-page":"391","article-title":"Parathyroid function after 131I therapy for hyperthyroidism","volume":"29","author":"ADAMS, P.H.; CHALMERS, Y.M.","year":"1965","unstructured":"ADAMS, P.H. & CHALMERS, Y.M. (1965) Parathyroid function after 131I therapy for hyperthyroidism. Clinical Science, 29, 391.","journal-title":"Clinical Science"},{"key":"ref_2","first-page":"646","article-title":"The management of recurrent thyrotoxicosis after thyroidectomy","volume":"45","author":"BAKER, G.; PIMSTONE, B.","year":"1971","unstructured":"BAKER, G, & PIMSTONE, B. (1971) The management of recurrent thyrotoxicosis after thyroidectomy. South African Medical Journal, 45, 646.","journal-title":"South African Medical Journal"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1148\/64.6.858","article-title":"The treatment of thyrotoxicosis with radio-iodine","volume":"64","author":"BALLS, K.F.; CHAMBERLAIN, R.H.; ROSE, E.; GORSON, R.O.; BLOUNT, H.C.","year":"1955","unstructured":"BALLS, K.F., CHAMBERLAIN, R.H., ROSE, E., GORSON, R.O. & BLOUNT, H.C. (1955) The treatment of thyrotoxicosis with radio-iodine. Radiology, 64, 858.","journal-title":"Radiology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1001\/archinte.1956.00250220013001","article-title":"Hyperthyroidism treated with radio-iodine: A 7-year experience","volume":"97","author":"BEIERWALTES, W.H.; JOHNSON, P.C.","year":"1956","unstructured":"BEIERWALTES, W.H. & JOHNSON, P.C. (1956) Hyperthyroidism treated with radio-iodine: A 7-year experience. Archives of Internal Medicine, 97, 393.","journal-title":"Archives of Internal Medicine"},{"key":"ref_5","first-page":"261","article-title":"Use of radioactive iodine in diagnosis and treatment of hyperthyroidism: 10 years'","volume":"34","author":"CHAPMAN, E.M.; MALOOF, F.","year":"1955","unstructured":"CHAPMAN, E.M. & MALOOF, F. (1955) Use of radioactive iodine in diagnosis and treatment of hyperthyroidism: 10 years' experience. Medicine, 34, 261.","journal-title":"experience. Medicine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1210\/jcem-14-1-45","article-title":"Ten years' experience with radioactive iodide","volume":"14","author":"CHAPMAN, E.M.; MALOOF, F.; MAISTERRENA, J.; MARTIN, J.","year":"1954","unstructured":"CHAPMAN, E.M., MALOOF, F., MAISTERRENA, J. & MARTIN, J. (1954) Ten years' experience with radioactive iodide. Journal of Clinical Endocrinology and Metabolism, 14, 45.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_7","first-page":"695","article-title":"Thyrotoxicosis in the Bantu, with special reference to myopathy","volume":"44","author":"DANCASTER, C.P.","year":"1970","unstructured":"DANCASTER, C.P. (1970) Thyrotoxicosis in the Bantu, with special reference to myopathy. South African Medical Journal, 44, 695.","journal-title":"South African Medical Journal"},{"key":"ref_8","first-page":"270","article-title":"Hypoparathyroidism following 1311 therapy for hyperthyroidism","volume":"121","author":"EIPE, J.; JOHNSON, S.A.; KAIMKO, R.T.; BRONSKY, D.","year":"1968","unstructured":"EIPE, J., JOHNSON, S.A., KAIMKO, R.T. & BRONSKY, D. (1968) Hypoparathyroidism following 1311 therapy for hyperthyroidism. Archives of Internal Medicine (Chicago), 121, 270.","journal-title":"Archives of Internal Medicine (Chicago)"},{"key":"ref_9","first-page":"812","article-title":"Practolol in hyperthyroid cardiac failure","volume":"45","author":"EPSTEIN, S.; PIMSTONE, B.","year":"1971","unstructured":"EPSTEIN, S. & PIMSTONE, B. (1971) Practolol in hyperthyroid cardiac failure. 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Journal of Nuclear Medicine, 5, 675.","journal-title":"Journal of Nuclear Medicine"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1001\/archinte.1967.00290190123011","article-title":"Why not radio-iodine therapy for toxic nodular goitre?","volume":"119","author":"HAMBURGER, J.I.; KADIAN, G.; ROSSIN, H.W.","year":"1967","unstructured":"HAMBURGER, J.I., KADIAN, G. & ROSSIN, H.W. (1967) Why not radio-iodine therapy for toxic nodular goitre? Archives of Internal Medicine, 119, 75.","journal-title":"Archives of Internal Medicine"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1056\/NEJM196812192792503","article-title":"When and how to use higher 1311 doses for hyperthyroidism","volume":"279","author":"HAMBURGER, J.I.; SUKHAMOY, P.","year":"1968","unstructured":"HAMBURGER, J.I. & SUKHAMOY, P. (1968) When and how to use higher 1311 doses for hyperthyroidism. New England Journal of Medicine, 279, 1361.","journal-title":"New England Journal of Medicine"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1056\/NEJM197010292831802","article-title":"Longterm results of treatment of thyrotoxicosis in children and adolescents with radioactive iodine","volume":"283","author":"HAYEK, A.; CHAPMAN, E.A.; CRAWFORD, J.D.","year":"1970","unstructured":"HAYEK, A., CHAPMAN, E.A. & CRAWFORD, J.D. (1970) Longterm results of treatment of thyrotoxicosis in children and adolescents with radioactive iodine. New England Journal of Medicine, 283, 949.","journal-title":"New England Journal of Medicine"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1136\/bmj.1.5695.519","article-title":"Surgical treatment of thyrotoxicosis","volume":"1","author":"HEDLEY, A.J.; FLEMING, C.J.; CHESTERS, M.I.; MICHIE, W.; CROOKS, I.J.","year":"1970","unstructured":"HEDLEY, A.J., FLEMING, C.J., CHESTERS, M.I., MICHIE, W. & CROOKS, I.J. (1970) Surgical treatment of thyrotoxicosis. British Medical Journal, 1, 519.","journal-title":"British Medical Journal"},{"key":"ref_20","first-page":"196","article-title":"Carcinoma of the thyroid following treatment of hyperthyroidism with radioactive iodine","volume":"101","author":"KARLAN, M.S.; POLLOCK, W.F.; SNYDER, W.H.","year":"1964","unstructured":"KARLAN, M.S., POLLOCK, W.F. & SNYDER, W.H. JR (1964) Carcinoma of the thyroid following treatment of hyperthyroidism with radioactive iodine. California Medicine, 101, 196.","journal-title":"JR"},{"key":"ref_21","article-title":"Iodine-125 treatment for thyrotoxicosis","volume":"840","author":"MCDOUGAL, I.R.; GREIG, W.R.; GRAY, H.W.; GILLESPIE, F.C.","year":"1970","unstructured":"MCDOUGAL, I.R., GREIG, W.R., GRAY, H.W. & GILLESPIE, F.C. (1970) Iodine-125 treatment for thyrotoxicosis. Lancet, ii, 840.","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1136\/bmj.2.5763.679","article-title":"Thyrotoxicosis in the African: clinical and immunological observations","volume":"2","author":"MCGILL, P.E.","year":"1971","unstructured":"MCGILL, P.E. (1971) Thyrotoxicosis in the African: clinical and immunological observations. British Medical Journal, 2, 679.","journal-title":"British Medical Journal"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1177\/003693306400901201","article-title":"Radio-iodine therapy in thyrotoxicosis: review of 908 cases","volume":"9","author":"MCGIRR, E.M.; THOMPSON, J.A.; MURRAY, I.P.C.","year":"1964","unstructured":"MCGIRR, E.M., THOMPSON, J.A. & MURRAY, I.P.C. (1964) Radio-iodine therapy in thyrotoxicosis: review of 908 cases. Scottish Medical Journal, 9, 505.","journal-title":"Scottish Medical Journal"},{"key":"ref_24","article-title":"Results of treatment of thyrotoxicosis after postoperative relapse","author":"MCLARTY, D.C.; ALEXANDER, W.D.H.A.R.D.E.N.; McG., R.; CLARK, D.H.","year":"1969","unstructured":"MCLARTY, D.C., ALEXANDER, W.D. HARDEN, R. McG. & CLARK, D.H. (1969) Results of treatment of thyrotoxicosis after postoperative relapse. British Medical Journal, 3, 200.","journal-title":"British Medical Journal"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"136","DOI":"10.7326\/0003-4819-75-1-136","article-title":"Hypoparathyroidism after 131I treatment of thyrotoxicosis","volume":"75","author":"ORME, M.C.L.'E.; CONOLLY, M.E.","year":"1971","unstructured":"ORME, M.C. L'E. & CONOLLY, M.E. (1971) Hypoparathyroidism after 131I treatment of thyrotoxicosis. Annals of Internal Medicine, 75, 136.","journal-title":"Annals of Internal Medicine"},{"key":"ref_26","first-page":"600","article-title":"Thyrotoxicosis at Mulago Hospital","volume":"39","author":"PATEL, K.M.","year":"1962","unstructured":"PATEL, K.M. (1962) Thyrotoxicosis at Mulago Hospital. East African Medical Journal, 39, 600.","journal-title":"East African Medical Journal"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1210\/jcem-13-1-107","article-title":"Results of treatment of toxic goitre with radioactive iodine","volume":"13","author":"SEED, L.; JAFFE, B.","year":"1953","unstructured":"SEED, L. & JAFFE, B. (1953) Results of treatment of toxic goitre with radioactive iodine. Journal of Clinical Endocrinology and Metabolism, 13, 107.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1210\/jcem-22-1-8","article-title":"Thyroid nodules occurring late after treatment of thyrotoxicosis with radioiodine","volume":"22","author":"SHELINE, G.E.; LINDSAY, S.; MCCORMACK, K.R.; GALANTE, M.","year":"1962","unstructured":"SHELINE, G.E., LINDSAY, S., MCCORMACK, K.R. & GALANTE, M. (1962) Thyroid nodules occurring late after treatment of thyrotoxicosis with radioiodine. Journal of Clinical Endocrinology and Metabolism, 22, 8.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1001\/archinte.1959.00270060076010","article-title":"Radioiodine therapy of hyperthyroidism","volume":"103","author":"SHELINE, G.E.; MILLER, E.R.","year":"1959","unstructured":"SHELINE, G.E. & MILLER, E.R. (1959) Radioiodine therapy of hyperthyroidism. Archives of Internal Medicine, 103, 924.","journal-title":"Archives of Internal Medicine"},{"key":"ref_30","first-page":"129","article-title":"Clinical trials ofdifferent doses of 1311 in treatment of thyrotoxicosis","volume":"1","author":"SMITH, R.N.; WILSON, G.M.","year":"1967","unstructured":"SMITH, R.N. & WILSON, G.M. (1967) Clinical trials ofdifferent doses of 1311 in treatment of thyrotoxicosis. British Medical Journal, 1, 129.","journal-title":"British Medical Journal"},{"key":"ref_31","article-title":"Prognosis of hyperthyroidism treated by antithyroid drugs","author":"SOLOMON, D.H.; BECK, J.C.; LAAN, V.A.N.D.E.R.; P., W.; ASTWOOD, E.B.","year":"1953","unstructured":"SOLOMON, D.H., BECK, J.C., VAN DER LAAN, W.P. & ASTWOOD, E.B. (1953). Prognosis of hyperthyroidism treated by antithyroid drugs. Journal of the American Medical Association, 152, 201.","journal-title":"Journal of the American Medical Association"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1056\/NEJM196407232710407","article-title":"Problem of hypothyroidism after 131I therapy of hyperthyroidism","volume":"271","author":"STANBURY, J.B.; GROOT, D.E.; J, L.","year":"1964","unstructured":"STANBURY, J.B. & DE GROOT, L.J. (1964) Problem of hypothyroidism after 131I therapy of hyperthyroidism. New England Journal of Medicine, 271, 195.","journal-title":"New England Journal of Medicine"},{"key":"ref_33","first-page":"390","article-title":"The thyroid in Western Nigeria","volume":"45","author":"TAYLOR, J.R.","year":"1968","unstructured":"TAYLOR, J.R. (1968) The thyroid in Western Nigeria. East African Medical Journal, 45, 390.","journal-title":"East African Medical Journal"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1210\/jcem-12-9-1220","article-title":"Temporary hypoparathyroidism following radio-active iodine treatment for thyrotoxicosis","volume":"12","author":"TIGHE, W.J.","year":"1952","unstructured":"TIGHE, W.J. (1952) Temporary hypoparathyroidism following radio-active iodine treatment for thyrotoxicosis. Journal of Clinical Endocrinology and Metabolism, 12, 1220.","journal-title":"Journal of Clinical Endocrinology and Metabolism"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/48\/559\/308\/50252971\/postgradmedj-48-308.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/48\/559\/308\/50252971\/postgradmedj-48-308.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T07:52:10Z","timestamp":1684223530000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/48\/559\/308\/7064674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,5,1]]},"references-count":34,"journal-issue":{"issue":"559","published-online":{"date-parts":[[1972,5,1]]},"published-print":{"date-parts":[[1972,5,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.48.559.308","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1972,5]]},"published":{"date-parts":[[1972,5,1]]}}}