{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T14:38:30Z","timestamp":1699713510087},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"564","license":[{"start":{"date-parts":[[1972,10,1]],"date-time":"1972-10-01T00:00:00Z","timestamp":86745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1972,10,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A retrospective analysis of thyroid scintiscanning at one hospital over a 3-year period revealed nineteen patients in whom a solitary, hyperfunctioning thyroid nodule was producing thyrotoxicosis.<\/jats:p>\n               <jats:p>Most of the patients had clinical features referable to hyperthyroidism and in the majority a solitary nodule was palpable in the neck which was found to correlate well with the location of the \u2018hot\u2019 nodule on scanning. Cardiac failure was present in 21% and atrial fibrillation occurred in 37%.<\/jats:p>\n               <jats:p>The 131I uptake by the thyroid was of little value in deciding whether or not the patient was toxic, but there was good agreement between serum protein bound iodine determinations and measurement of serum thyroxine and resin uptake tests. There appeared to be no relationship between the size of the nodule and its degree of activity.<\/jats:p>","DOI":"10.1136\/pgmj.48.564.577","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:27:15Z","timestamp":1230582435000},"page":"577-583","source":"Crossref","is-referenced-by-count":6,"title":["Thyroid \u2018hot\u2019 nodules"],"prefix":"10.1093","volume":"48","author":[{"given":"Ian","family":"Ramsay","sequence":"first","affiliation":[{"name":"Department of Medicine, King's College Hospital Medical School , Denmark Hill, London, S.E.5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Medicine, King's College Hospital Medical School , Denmark Hill, London, S.E.5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Marsden","sequence":"additional","affiliation":[{"name":"Department of Medicine, King's College Hospital Medical School , Denmark Hill, London, S.E.5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C G","family":"McKerron","sequence":"additional","affiliation":[{"name":"Department of Medicine, King's College Hospital Medical School , Denmark Hill, London, S.E.5"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1972,10,1]]},"reference":[{"key":"ref_1","first-page":"7","article-title":"Assessment of thyroid function and anatomy with technetium-99m as pertechnetate","volume":"9","author":"ATKINS, H.L.; RICHARDS, P.","year":"1968","unstructured":"ATKINS, H.L. & RICHARDS, P. (1968) Assessment of thyroid function and anatomy with technetium-99m as pertechnetate. Journal of Nuclear Medicine, 9, 7.","journal-title":"Journal of Nuclear Medicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"886","DOI":"10.2214\/ajr.103.4.886","article-title":"Probability values for protein-bound iodine, thyroid 1311 uptakes and T3 resin uptakes for hypothyroidism, euthyroidism and hyperthyroidism","volume":"103","author":"BENDER, C.E.; FITZGERALD, L.T.; WILLIAMS, C.M.","year":"1968","unstructured":"BENDER, C.E., FITZGERALD, L.T. & WILLIAMS, C.M. (1968) Probability values for protein-bound iodine, thyroid 1311 uptakes and T3 resin uptakes for hypothyroidism, euthyroidism and hyperthyroidism. 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(1964)"},{"key":"ref_30","first-page":"176","article-title":"Clinical Aspects of Iodine Metabolism","volume":"80","author":"In; Publications, Scientific; WILANSKY, Oxford; L., D.; KALANT, N.; WOLFSON, J.","year":"1959","unstructured":"In: Clinical Aspects of Iodine Metabolism, p. 176. Blackwe 11 Scientific Publications, Oxford. WILANSKY, D.L., KALANT, N. & WOLFSON, J. (1959) Thyroid function in apathetic hyperthyroidism. 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