{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T04:29:55Z","timestamp":1684297795109},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"564","license":[{"start":{"date-parts":[[1972,10,1]],"date-time":"1972-10-01T00:00:00Z","timestamp":86745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1972,10,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>In a review of 874 Nigerian patients with various types of thyroid gland disorders, forty-six patients were found to be thyrotoxic (5\u00b73%), supporting the common observation of many authors that thyrotoxicosis is rarer in the African than in Europe and North America where thyrotoxicosis accounts for 20\u201350% of all thyroidectomies. The incidence of thyrotoxicosis is higher in the female than male though there is a higher proportion of males in this series than in the United Kingdom. There is a higher incidence of secondary thyrotoxicosis than has been reported elsewhere.<\/jats:p>\n               <jats:p>The clinical features of hyperthyroidism in the Nigerian are no different from those reported in other countries, though our patients tend to report rather late. Primary thyrotoxicosis occured a decade earlier in this series than in Britain. Two of the forty-six patients had adenocarcinoma of the thyroid although only in twenty-seven patients was thyroid tissue available for histological examination. Laboratory investigations were essential in borderline cases, especially estimation of the PBI in those with multinodular goitres.<\/jats:p>\n               <jats:p>The standard methods of treatment by antithyroid drugs, 131I and surgery were employed with immediately satisfactory results, though the follow-up was so poor that it is impossible to evaluate the late effects of treatment.<\/jats:p>","DOI":"10.1136\/pgmj.48.564.609","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:27:15Z","timestamp":1230582435000},"page":"609-615","source":"Crossref","is-referenced-by-count":1,"title":["Thyrotoxicosis in Nigeria\u2014a study of forty-six patients"],"prefix":"10.1093","volume":"48","author":[{"given":"E O","family":"Olurin","sequence":"first","affiliation":[{"name":"Department of Surgery, University College Hospital , Ibadan, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1972,10,1]]},"reference":[{"key":"ref_1","first-page":"by","article-title":"A study of thyrotoxicosis in Lagos","author":"ADESOLA, A.O.","year":"1970","unstructured":"ADESOLA, A.O. 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