{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T09:41:11Z","timestamp":1684230071482},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"570","license":[{"start":{"date-parts":[[1973,4,1]],"date-time":"1973-04-01T00:00:00Z","timestamp":102470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1973,4,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A variety of hepatic manifestations may occur during attacks of acute amoebic dysentery, conforming to clearly defined clinical groups.<\/jats:p>\n               <jats:p>The incidence of definite hepatic involvement presenting as cases of hepatic amoebiasis with or without demonstrable pus or with tender hepatomegaly was 57\u00b75%.<\/jats:p>\n               <jats:p>While it is possible that the cases presenting with hepatic manifestations without demonstrable pus are due to small deep-seated abscesses, the non-specific nature of the histological lesions observed in the study and the inability to demonstrate the presence of amoebae in the lesions support the contention that these hepatic manifestations may represent a non-specific reaction in the liver to amoebic ulceration of the colon.<\/jats:p>\n               <jats:p>Chest radiology may be helpful in confirming the clinical evidence of hepatic involvement but the leucocyte count, ESR, and the serum enzymes are of limited value in indicating both its presence and type.<\/jats:p>\n               <jats:p>Patients manifesting hepatic involvement during attacks of amoebic dysentery should be adequately treated with tissue amoebicidals. This therapeutic approach would be useful in reducing the incidence of hepatic amoebiasis.<\/jats:p>","DOI":"10.1136\/pgmj.49.570.261","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:31:39Z","timestamp":1230582699000},"page":"261-264","source":"Crossref","is-referenced-by-count":5,"title":["Hepatic manifestations during amoebic dysentery"],"prefix":"10.1093","volume":"49","author":[{"given":"S","family":"Ramachandran","sequence":"first","affiliation":[{"name":"Colombo North General Hospital , Ragama, Sri Lanka"},{"name":"The Medical Research Institute , Colombo, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C N A","family":"Rajapakse","sequence":"additional","affiliation":[{"name":"Colombo North General Hospital , Ragama, Sri Lanka"},{"name":"The Medical Research Institute , Colombo, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"de Saram","sequence":"additional","affiliation":[{"name":"Colombo North General Hospital , Ragama, Sri Lanka"},{"name":"The Medical Research Institute , Colombo, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Sivalingam","sequence":"additional","affiliation":[{"name":"Colombo North General Hospital , Ragama, Sri Lanka"},{"name":"The Medical Research Institute , Colombo, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1973,4,1]]},"reference":[{"key":"ref_1","first-page":"338","article-title":"Amoebic abscess of the liver","volume":"45","author":"BANKER, D.D.","year":"1947","unstructured":"BANKER, D.D. (1947) Amoebic abscess of the liver. Tropical Diseases Bulletin, 45, 338.","journal-title":"Tropical Diseases Bulletin"},{"key":"ref_2","article-title":"The Etiology and Diagnosis and Treatment of Amoebiasis. Williams and Wilkins","author":"CRAIG, C.F.","year":"1944","unstructured":"CRAIG, C.F. (1944) The Etiology and Diagnosis and Treatment of Amoebiasis. Williams and Wilkins Co., Baltimore."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1001\/jama.1903.92490270008001c","article-title":"A study of the cases of amoebic dysentery occurring at the Johns Hopkins Hospital","volume":"42","author":"FUTCHER, T.B.","year":"1903","unstructured":"FUTCHER, T.B. (1903) A study of the cases of amoebic dysentery occurring at the Johns Hopkins Hospital. Journal of the American Medical Association, 42, 480.","journal-title":"Journal of the American Medical Association"},{"key":"ref_4","first-page":"390","article-title":"Hepatic amoebiasis","volume":"27","author":"Ramachandran, S.","year":"1958","unstructured":"S. Ramachandran et al. LAMONT, N.McE. & POOLER, N.R. (1958) Hepatic amoebiasis. Quarterly Journal of Medicine, 27, 390.","journal-title":"Quarterly Journal of Medicine"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1136\/pgmj.47.551.615","article-title":"Radiological changes in hepatic amoebiasis","volume":"47","author":"RAMACHANDRAN, S.; JAYAWARDENA, D.L.N.; PERUMAL, J.R.A.","year":"1971","unstructured":"RAMACHANDRAN, S., JAYAWARDENA, D.L.N. & PERUMAL, J.R.A. (1971) Radiological changes in hepatic amoebiasis. Postgraduate Medical Journal, 47, 615.","journal-title":"Postgraduate Medical Journal"},{"key":"ref_6","first-page":"34","article-title":"Hepatic amoebiasis in Ceylon","volume":"75","author":"RAMACHANDRAN, S.; SIVALINGAM, S.; PERUMAL, J.R.A.","year":"1972","unstructured":"RAMACHANDRAN, S., SIVALINGAM, S. & PERUMAL, J.R.A. (1972a) Hepatic amoebiasis in Ceylon. Journal of Tropical Medicine and Hygiene, 75, 34.","journal-title":"Journal of Tropical Medicine and Hygiene"},{"key":"ref_7","article-title":"Concepts in hepatic amoebiasis","author":"RAMACHANDRAN, S.; SIVALINGAM, S.; PERUMAL, J.R.A.","year":"1973","unstructured":"RAMACHANDRAN, S., SIVALINGAM, S. & PERUMAL, J.R.A. (1973) Concepts in hepatic amoebiasis. Journal of Tropical Medicine and Hygiene, February.","journal-title":"Journal of Tropical Medicine and Hygiene"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/49\/570\/261\/50253326\/postgradmedj-49-261.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/49\/570\/261\/50253326\/postgradmedj-49-261.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T09:13:04Z","timestamp":1684228384000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/49\/570\/261\/7064274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,4,1]]},"references-count":7,"journal-issue":{"issue":"570","published-online":{"date-parts":[[1973,4,1]]},"published-print":{"date-parts":[[1973,4,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.49.570.261","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1973,4]]},"published":{"date-parts":[[1973,4,1]]}}}