{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T04:51:17Z","timestamp":1773895877297,"version":"3.50.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"579","license":[{"start":{"date-parts":[[1974,1,1]],"date-time":"1974-01-01T00:00:00Z","timestamp":126230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1974,1,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Among fifty-seven patients with proven coeliac disease three also had thyrotoxicosis, two insulin dependant diabetes, three fibrosing alveolitis and one each had vitiligo, rheumatoid arthritis and cryptogenic cirrhosis. Autoantibodies were demonstrated in twelve of thirty-one patients tested, seven of these twelve had one of the above associated conditions. Antireticulin antibodies were found in seven of twenty-three patients tested, and there was a significant association with dietary gluten. These findings appear to support that coeliac disease is associated with disturbed immunity and that a predisposition to autoimmunity may exist.<\/jats:p>","DOI":"10.1136\/pgmj.50.579.45","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:31:39Z","timestamp":1230582699000},"page":"45-48","source":"Crossref","is-referenced-by-count":60,"title":["Coeliac disease and autoimmunity"],"prefix":"10.1093","volume":"50","author":[{"given":"M J","family":"Lancaster-Smith","sequence":"first","affiliation":[{"name":"The Departments of Gastroenterology and Clinical Immunology, The London Hospital , London, E.1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E T","family":"Swarbrick","sequence":"additional","affiliation":[{"name":"The Departments of Gastroenterology and Clinical Immunology, The London Hospital , London, E.1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Perrin","sequence":"additional","affiliation":[{"name":"The Departments of Gastroenterology and Clinical Immunology, The London Hospital , London, E.1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J T","family":"Wright","sequence":"additional","affiliation":[{"name":"The Departments of Gastroenterology and Clinical Immunology, The London Hospital , London, E.1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1974,1,1]]},"reference":[{"key":"ref_1","article-title":"Autoantibodies to reticulin in patients with idiopathic steatorrhoea, coeliac disease, and Crohn's disease, and their relation to immunoglobulins and dietary antibodies","volume":"682","author":"ALP, M.H.; WRIGHT, R.","year":"1971","unstructured":"ALP, M.H. & WRIGHT, R. (1971) Autoantibodies to reticulin in patients with idiopathic steatorrhoea, coeliac disease, and Crohn's disease, and their relation to immunoglobulins and dietary antibodies. Lancet, ii, 682.","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1136\/gut.10.1.57","article-title":"Serum immunoglobulins and lymphocyte transformation studies in coeliac disease","volume":"10","author":"BLECHER, T.E.; BRECHWA-ADJUKIEWICZ, A.; MCCARTHY, C.F.; READ, A.E.","year":"1969","unstructured":"BLECHER, T.E., BRECHWA-ADJUKIEWICZ, A., MCCARTHY, C.F. & READ, A.E. (1969) Serum immunoglobulins and lymphocyte transformation studies in coeliac disease. Gut, 10, 57.","journal-title":"Gut"},{"key":"ref_3","first-page":"153","article-title":"Schmidt's syndrome (thyroid and adrenal insufficiency). A review of the literature and a report of fifteen new cases including ten instances of co-existing diabetes mellitus","volume":"43","author":"CARPENTER, C.C.H.; SOLOMON, N.; SILVERBERG, S.G.; BLEDSOE, T.; NORTHcuTT, R.C.; KLINENBERG, J.R.; BENNETT, I.L.; HARVEY, McGEHEE; A.","year":"1964","unstructured":"CARPENTER, C.C.H., SOLOMON, N., SILVERBERG, S.G., BLEDSOE, T., NORTHcuTT, R.C., KLINENBERG, J.R., BENNETT, I.L. & McGEHEE HARVEY, A. (1964) Schmidt's syndrome (thyroid and adrenal insufficiency). A review of the literature and a report of fifteen new cases including ten instances of co-existing diabetes mellitus. Medicine (Baltimore), 43, 153.","journal-title":"Medicine (Baltimore)"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1136\/bmj.3.5716.207","article-title":"A Case of Malabsorption, Intestinal Mucosal Atrophy and Ulceration, Cirrhosis, and Emphysema","volume":"3","author":"CONFERENCE, C.L.I.N.I.C.O.P.A.T.H.O.L.O.G.I.C.A.L.","year":"1970","unstructured":"CLINICOPATHOLOGICAL CONFERENCE (1970) A Case of Malabsorption, Intestinal Mucosal Atrophy and Ulceration, Cirrhosis, and Emphysema. British Medical Journal, 3, 207.","journal-title":"British Medical Journal"},{"key":"ref_5","article-title":"A unified concept of autoimmune hepatitis","volume":"813","author":"DONIACH, D.; WALKER, J.G.","year":"1969","unstructured":"DONIACH, D. & WALKER, J.G. (1969) A unified concept of autoimmune hepatitis. Lancet, i, 813.","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/S0016-5085(19)33750-3","article-title":"Immunochemical studies of the serum, intestinal secretions and intestinal mucosa in patients with adult celiac disease and other forms of the celiac syndrome","volume":"59","author":"DOUGLAS, A.P.; CRABBE, P.A.; HOBBS, J.R.","year":"1970","unstructured":"DOUGLAS, A.P., CRABBE, P.A. & HOBBS, J.R. (1970) Immunochemical studies of the serum, intestinal secretions and intestinal mucosa in patients with adult celiac disease and other forms of the celiac syndrome. Gastroenterology, 59, 414.","journal-title":"Gastroenterology"},{"key":"ref_7","first-page":"1298","article-title":"Vitiligo","volume":"ii,","author":"E.D.I.T.O.R.I.A.L.","year":"1971","unstructured":"EDITORIAL (1971) Vitiligo. Lancet, ii, 1298.","journal-title":"Lancet"},{"key":"ref_8","article-title":"Detection of antibodies which can co-operate with lymphocytes","volume":"403","author":"FAKHRI, 0. & HOBBS, J. R","year":"1972","unstructured":"FAKHRI, 0. & HOBBS, J.R. (1972) Detection of antibodies which can co-operate with lymphocytes. Lancet, ii, 403.","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1136\/jcp.14.6.654","article-title":"A stable sheepcell preparation of dietary thryoglobulin autoantibodies and its clinical application","volume":"14","author":"FULTHORPE, A.J.; ROITT, I.M.; DONIACH, D.; COUCHMAN, K.","year":"1961","unstructured":"FULTHORPE, A.J., ROITT, I.M., DONIACH, D. & COUCHMAN, K. (1961) A stable sheepcell preparation of dietary thryoglobulin autoantibodies and its clinical application. Journal of Clinical Pathology, 14, 654.","journal-title":"Journal of Clinical Pathology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"619","DOI":"10.2337\/diab.14.10.619","article-title":"Pathological anatomy of the pancreas in juvenile diabetes mellitus","volume":"14","author":"GEPTS, W.","year":"1965","unstructured":"GEPTS, W. (1965) Pathological anatomy of the pancreas in juvenile diabetes mellitus. Diabetes, 14, 619.","journal-title":"Diabetes"},{"key":"ref_11","article-title":"Serological diagnosis of idiopathic Addison's disease in patients on prolonged prednisolone therapy for steatorrhoea","volume":"186","author":"GOUDIE, R.B.; BOYLE, I.T.; STUART-SMITH, D.A.; FERGUSON, A.","year":"1969","unstructured":"GOUDIE, R.B., BOYLE, I.T., STUART-SMITH, D.A. & FERGUSON, A. (1969) Serological diagnosis of idiopathic Addison's disease in patients on prolonged prednisolone therapy for steatorrhoea. Lancet, i, 186.","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3109\/00365526909179925","article-title":"Small intestinal histology, radiology and absorption in hyperthyroidism","volume":"4","author":"HEILESEN, C.; FRIIs, T.; LARSEN, E.; POCK-STEEN, O.C.","year":"1969","unstructured":"HEILESEN, C., FRIIs, T., LARSEN, E. & POCK-STEEN, O.C. (1969) Small intestinal histology, radiology and absorption in hyperthyroidism. Scandinavian Journal of Gastroenterology, 4, 169.","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"ref_13","article-title":"Immune imbalance in dysgammaglobulinaemia type IV","volume":"110","author":"HOBBS, J.","year":"1968","unstructured":"HOBBS, J. (1968) Immune imbalance in dysgammaglobulinaemia type IV. Lancet, i, 110.","journal-title":"Lancet"},{"key":"ref_14","article-title":"Immunological disturbances in the pathogenesis of malabsorption","author":"HOBBS, J.","year":"1971","unstructured":"HOBBS, J. (1971) Immunological disturbances in the pathogenesis of malabsorption. Journal of Clinical Pathology.","journal-title":"Journal of Clinical Pathology"},{"key":"ref_15","article-title":"Diffuse pulmonary disease with transfer defect occurring with coeliac disease","volume":"445","author":"HOOD, J.; MASON, A.M.S.","year":"1970","unstructured":"HOOD, J. & MASON, A.M.S. (1970) Diffuse pulmonary disease with transfer defect occurring with coeliac disease. Lancet, i, 445.","journal-title":"Lancet"},{"key":"ref_16","first-page":"478","article-title":"Malabsorption and diabetes mellitus in children","volume":"5","author":"HOOF, C.; DEVOS, E.; KRIEKEMANNS, J.; DAMME, V.A.N.; J.","year":"1968","unstructured":"HOOF, C., DEVOS, E., KRIEKEMANNS, J. & VAN DAMME, J. (1968) Malabsorption and diabetes mellitus in children. Helvetica Paediatrica Acta, 5, 478.","journal-title":"Helvetica Paediatrica Acta"},{"key":"ref_17","article-title":"Autoantibodies in diabetes mellitus","volume":"163","author":"DUNCAN, L.J.P.","year":"1970","unstructured":"& DUNCAN, L.J.P. (1970) Autoantibodies in diabetes mellitus. Lancet, ii, 163.","journal-title":"Lancet"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3109\/00365527109181130","article-title":"Gastrointestinal findings in autoimmune thyroiditis and non-goitrous juvenile hypothyroidism in children","volume":"6","author":"KUITUNEN, P.; MAENPUA, J.; KROHN, K.; VISKORPI, J.K.","year":"1971","unstructured":"KUITUNEN, P., MAENPUA, J., KROHN, K. & VISKORPI, J.K. (1971) Gastrointestinal findings in autoimmune thyroiditis and non-goitrous juvenile hypothyroidism in children. Scandinavian Journal of Gastroenterology, 6, 335.","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"ref_19","article-title":"Coeliac disease and diffuse interstitial lung disease","volume":"473","author":"LANCASTER-SMITH, M.J.; BENSON, M.K.; STRICKLAND, I.D.","year":"1971","unstructured":"LANCASTER-SMITH, M.J., BENSON, M.K. & STRICKLAND, I.D. (1971) Coeliac disease and diffuse interstitial lung disease. Lancet, i, 473.","journal-title":"Lancet"},{"key":"ref_20","article-title":"Diffuse fibrosing alveolitis, two cases with autoimmune features","author":"MACKAY, I.R.; RITCHIE, B.","year":"1965","unstructured":"MACKAY, I.R. & RITCHIE, B. (1965) Diffuse fibrosing alveolitis, two cases with autoimmune features. Thorax, 20, 200."},{"key":"ref_21","first-page":"1179","article-title":"In vitro inhibition of leucocyte migration by sarcoid spleen suspension in coeliac disease and dermatitis herpetiformis","volume":"ii,","author":"PAGALTSOS, A.S.; KUMAR, P.J.; WILLOUGHBY, J.T.M.; DAWSON, A.M.","year":"1971","unstructured":"PAGALTSOS, A.S., KUMAR, P.J., WILLOUGHBY, J.T.M. & DAWSON, A.M. (1971) In vitro inhibition of leucocyte migration by sarcoid spleen suspension in coeliac disease and dermatitis herpetiformis. Lancet, ii, 1179.","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0016-5085(65)80072-5","article-title":"Sjogren's Syndrome and adult celiac disease","volume":"48","author":"PITTMAN, F.E.; HOLUB, D.A.","year":"1965","unstructured":"PITTMAN, F.E. & HOLUB, D.A. (1965) Sjogren's Syndrome and adult celiac disease. Gastroenterology, 48, 869.","journal-title":"Gastroenterology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1136\/bmj.1.5438.827","article-title":"Small-intestinal and gastric abnormalities in ulcerative colitis","volume":"1","author":"SALEM, S.N.; TRUELOVE, S.C.","year":"1965","unstructured":"SALEM, S.N. & TRUELOVE, S.C. (1965) Small-intestinal and gastric abnormalities in ulcerative colitis. British Medical Journal, 1, 827.","journal-title":"British Medical Journal"},{"key":"ref_24","article-title":"Tissue antibodies in dermatitis herpetiformis and adult coeliac disease","volume":"834","author":"SEAH, P.A.; FRY, L.; HOFFBRAND, A.V.; HOLBOROW, E.J.","year":"1971","unstructured":"SEAH, P.A., FRY, L., HOFFBRAND, A.V. & HOLBOROW, E.J. (1971) Tissue antibodies in dermatitis herpetiformis and adult coeliac disease. Lancet, i, 834.","journal-title":"Lancet"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.0954-6820.1968.tb02422.x","article-title":"Intestinal absorption and autoimmunity in endocrine disorders","volume":"184","author":"SIURULA, M.; VARIs, K.; LAMBERG, B.A.","year":"1968","unstructured":"SIURULA, M., VARIs, K. & LAMBERG, B.A. (1968) Intestinal absorption and autoimmunity in endocrine disorders. Acta Medica Scandinavica, 184, 53.","journal-title":"Acta Medica Scandinavica"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/S0140-6736(69)92512-4","article-title":"Diabetes and coeliac disease","volume":"ii,","author":"VISAKORPI, J.K.","year":"1969","unstructured":"VISAKORPI, J.K. (1969) Diabetes and coeliac disease. Lancet, ii, 1192.","journal-title":"Lancet"},{"key":"ref_27","first-page":"48","article-title":"Postgraduate Medical Journal (Januasy","volume":"50","year":"1974","unstructured":"Postgraduate Medical Journal (Januasy 1974) 50, 48-50."},{"key":"ref_28","article-title":"Introduction Non-parasitic cysts of the liver are relatively uncommon, and are usually discovered as incidental findings at laparotomy. Complications arising in such cysts are rare, but occasional reports of these have occurred in the literature. Rupture into the peritoneal cavity (Horton, 1954), intracystic haemorrhage (Ackman and Rhea, 1931) and strangulation (Orr and Thurston, 1927; Grime","year":"1959","unstructured":"Introduction Non-parasitic cysts of the liver are relatively uncommon, and are usually discovered as incidental findings at laparotomy. Complications arising in such cysts are rare, but occasional reports of these have occurred in the literature. Rupture into the peritoneal cavity (Horton, 1954), intracystic haemorrhage (Ackman and Rhea, 1931) and strangulation (Orr and Thurston, 1927; Grime et al., 1959) have been described presenting as an acute abdominal emergency. We report a case of a solitary non-parasitic cyst arising from the liver having undergone sudden spontaneous torsion on a pedicle and presenting as an acute abdominal emergency.","journal-title":"et al; have been described presenting as an acute abdominal emergency. We report a case of a solitary non-parasitic cyst arising from the liver having undergone sudden spontaneous torsion on a pedicle and presenting as an acute abdominal emergency"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/50\/579\/45\/50254139\/postgradmedj-50-45.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/50\/579\/45\/50254139\/postgradmedj-50-45.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T02:47:28Z","timestamp":1709866048000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/50\/579\/45\/7064135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,1,1]]},"references-count":28,"journal-issue":{"issue":"579","published-online":{"date-parts":[[1974,1,1]]},"published-print":{"date-parts":[[1974,1,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.50.579.45","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1974,1]]},"published":{"date-parts":[[1974,1,1]]}}}